RUSF1 Gene

Name RUS family member 1
Description This gene encodes a putative transmembrane protein containing a conserved DUF647 domain that may be involved in protein-protein interaction. The encoded protein is related to a plant protein that participates in ultraviolet B light-sensing during root morphogenesis. [provided by RefSeq, Feb 2013]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRUSF1, a member of the RUS (ROOT UV‐B SENSITIVE) family of proteins in Arabidopsis, functions as a critical regulator in early seedling morphogenesis by mediating the plant’s response to low‐intensity UV‐B light. Genetic and molecular studies have revealed that RUSF1 (represented by RUS1) works in concert with its homolog RUS2, a DUF647‐containing protein, to establish a specialized UV‐B sensing pathway in the root. Both proteins exhibit highly similar expression patterns and interact directly through their conserved DUF647 domain; specific residues within this motif are essential for their physical association and proper function. The RUS pathway is vital for normal seedling development under very‐low-fluence UV‐B conditions, and its evolutionary conservation—evidenced by the presence of multiple RUS family members in Arabidopsis, rice, and even moss (with one member extending to animals)—underscores its fundamental role in environmental response and developmental regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Colin D Leasure, Hongyun Tong, Gigi Yuen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ROOT UV-B SENSITIVE2 acts with ROOT UV-B SENSITIVE1 in a root ultraviolet B-sensing pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Plant Physiol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1104/pp.109.139253"}], "href": "https://doi.org/10.1104/pp.109.139253"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19515790"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19515790"}]}]}]}
NCBI Gene ID 64755
API
Download Associations
Predicted Functions View RUSF1's ARCHS4 Predicted Functions.
Co-expressed Genes View RUSF1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View RUSF1's ARCHS4 Predicted Functions.

Functional Associations

RUSF1 has 1,409 functional associations with biological entities spanning 6 categories (chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 22 datasets.

Click the + buttons to view associations for RUSF1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of RUSF1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
Carcinogenome Chemical Perturbation Carcinogenicity Signatures small molecule perturbations changing expression of RUSF1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
CCLE Cell Line Proteomics Cell lines associated with RUSF1 protein from the CCLE Cell Line Proteomics dataset.
CM4AI KOLF21J CRISPRi Gene Perturbation Atlas gene perturbations changing expression of RUSF1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
CM4AI U2OS Cell Map Protein Localization Assemblies assemblies containing RUSF1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
DepMap CRISPR Gene Dependency cell lines with fitness changed by RUSF1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
DisGeNET Gene-Disease Associations diseases associated with RUSF1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
DisGeNET Gene-Phenotype Associations phenotypes associated with RUSF1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
GTEx eQTL 2025 SNPs regulating expression of RUSF1 gene from the GTEx eQTL 2025 dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of RUSF1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GTEx Tissue-Specific Aging Signatures tissue samples with high or low expression of RUSF1 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset.
GWAS Catalog SNP-Phenotype Associations 2025 phenotypes associated with RUSF1 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of RUSF1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
JASPAR Predicted Mouse Transcription Factor Targets 2025 transcription factors regulating expression of RUSF1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures small molecule perturbations changing expression of RUSF1 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures gene perturbations changing expression of RUSF1 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of RUSF1 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of RUSF1 gene from the Rummagene Transcription Factor Associations 2026 dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of RUSF1 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of RUSF1 gene from the RummaGEO Gene Perturbation Signatures dataset.
Sci-Plex Drug Perturbation Signatures drug perturbations changing expression of RUSF1 gene from the Sci-Plex Drug Perturbation Signatures dataset.
Tahoe Therapeutics Tahoe 100M Perturbation Atlas drug perturbations changing expression of RUSF1 gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.