{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nS100A7, also known as psoriasin, is a calcium‐binding protein originally identified in psoriatic skin that plays a fundamental role in innate epithelial defense. In several studies, S100A7 is shown to be produced by keratinocytes and secreted into the extracellular milieu where it exerts potent antimicrobial activity—preferentially against Escherichia coli—thereby contributing to the first‐line barrier of the skin, oral mucosa, tongue, and other epithelia. Elevated S100A7 expression has been documented in inflammatory skin conditions (such as atopic dermatitis and psoriasis), in wounds, and even in secretions from the nasal and vaginal epithelia, suggesting that rapid induction and release of S100A7 is critical to protect these tissues from microbial invasion."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its antimicrobial function, S100A7 serves as an important modulator of inflammatory and differentiation‐related signaling. Several reports have demonstrated that S100A7 can act as a chemoattractant for various immune cell subsets by interacting with receptors such as RAGE, and its binding affinity is modulated by trace elements like zinc. Its expression is regulated by inflammatory cytokines (for example, IL-17A, TNF-α, oncostatin-M) and cellular stress signals, with downstream effects including the induction of proinflammatory mediators, reactive oxygen species generation, and alterations in keratinocyte differentiation. These observations underscore a dual role of S100A7 in both propagating inflammatory signals and orchestrating cellular responses that maintain barrier integrity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "25"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in host defense and the regulation of inflammatory pathways, S100A7 has emerged as a key player in tumorigenesis and cancer progression. A number of studies have linked aberrant overexpression of S100A7 to various epithelial cancers—including breast (with distinct effects in estrogen receptor–positive versus –negative subtypes), cervical, oral, prostate, ovarian, and esophageal carcinomas—and to preneoplastic lesions such as leukoplakia. Depending on the cellular context, S100A7 may promote cell proliferation, motility, invasion, angiogenesis, and remodeling of the tumor microenvironment through interactions with receptors (e.g., RAGE) and intracellular partners (such as integrin subunits), while in other settings it appears to exert tumor-suppressive functions by modulating β-catenin signaling. Accordingly, S100A7 is being evaluated as a potential diagnostic biomarker and therapeutic target for predicting metastasis and clinical outcome."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "26", "end_ref": "46"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Malin Bryborn, Mikael Adner, Lars-Olaf Cardell "}, {"type": "b", "children": [{"type": "t", "text": "Psoriasin, one of several new proteins identified in nasal lavage fluid from allergic and non-allergic individuals using 2-dimensional gel electrophoresis and mass spectrometry."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Respir Res (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1465-9921-6-118"}], "href": "https://doi.org/10.1186/1465-9921-6-118"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16236163"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16236163"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kathleen C Lee, Richard L Eckert "}, {"type": "b", "children": [{"type": "t", "text": "S100A7 (Psoriasin)--mechanism of antibacterial action in wounds."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.jid.5700663"}], "href": "https://doi.org/10.1038/sj.jid.5700663"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17159909"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17159909"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Arby Abtin, Leopold Eckhart, Michael Mildner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Flagellin is the principal inducer of the antimicrobial peptide S100A7c (psoriasin) in human epidermal keratinocytes exposed to Escherichia coli."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.07-104117"}], "href": "https://doi.org/10.1096/fj.07-104117"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18263703"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18263703"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Regine Gläser, Ulf Meyer-Hoffert, Jürgen Harder, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The antimicrobial protein psoriasin (S100A7) is upregulated in atopic dermatitis and after experimental skin barrier disruption."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jid.2008.268"}], "href": "https://doi.org/10.1038/jid.2008.268"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18754038"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18754038"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "J E Meyer, J Harder, B Sipos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Psoriasin (S100A7) is a principal antimicrobial peptide of the human tongue."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mucosal Immunol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/mi.2008.3"}], "href": "https://doi.org/10.1038/mi.2008.3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19079183"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19079183"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Matthias Michalek, Christoph Gelhaus, Oliver Hecht, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The human antimicrobial protein psoriasin acts by permeabilization of bacterial membranes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Comp Immunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.dci.2008.12.005"}], "href": "https://doi.org/10.1016/j.dci.2008.12.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19162067"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19162067"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "M Mildner, M Stichenwirth, A Abtin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Psoriasin (S100A7) is a major Escherichia coli-cidal factor of the female genital tract."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mucosal Immunol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/mi.2010.37"}], "href": "https://doi.org/10.1038/mi.2010.37"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20571488"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20571488"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Fabian Garreis, Maria Gottschalt, Thomas Schlorf, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression and regulation of antimicrobial peptide psoriasin (S100A7) at the ocular surface and in the lacrimal apparatus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Invest Ophthalmol Vis Sci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1167/iovs.10-6598"}], "href": "https://doi.org/10.1167/iovs.10-6598"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21551409"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21551409"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Maike Wittersheim, Jesko Cordes, Ulf Meyer-Hoffert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential expression and in vivo secretion of the antimicrobial peptides psoriasin (S100A7), RNase 7, human beta-defensin-2 and -3 in healthy human skin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Dermatol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/exd.12133"}], "href": "https://doi.org/10.1111/exd.12133"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23614747"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23614747"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Monica Ruse, Ann-Marie Broome, Richard L Eckert "}, {"type": "b", "children": [{"type": "t", "text": "S100A7 (psoriasin) interacts with epidermal fatty acid binding protein and localizes in focal adhesion-like structures in cultured keratinocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1046/j.1523-1747.2003.12309.x"}], "href": "https://doi.org/10.1046/j.1523-1747.2003.12309.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12839573"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12839573"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Hanna Martinsson, Maria Yhr, Charlotta Enerbäck "}, {"type": "b", "children": [{"type": "t", "text": "Expression patterns of S100A7 (psoriasin) and S100A9 (calgranulin-B) in keratinocyte differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Dermatol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.0906-6705.2005.00239.x"}], "href": "https://doi.org/10.1111/j.0906-6705.2005.00239.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15740587"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15740587"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Stina Petersson, Anna Bylander, Maria Yhr, et al. "}, {"type": "b", "children": [{"type": "t", "text": "S100A7 (Psoriasin), highly expressed in ductal carcinoma in situ (DCIS), is regulated by IFN-gamma in mammary epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-7-205"}], "href": "https://doi.org/10.1186/1471-2407-7-205"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17986321"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17986321"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Sara L Richer, Ai Q Truong-Tran, David B Conley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epithelial genes in chronic rhinosinusitis with and without nasal polyps."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Rhinol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2500/ajr.2008.22.3162"}], "href": "https://doi.org/10.2500/ajr.2008.22.3162"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18588753"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18588753"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Ronald Wolf, O M Zack Howard, Hui-Fang Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.181.2.1499"}], "href": "https://doi.org/10.4049/jimmunol.181.2.1499"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18606705"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18606705"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Chiara Baldini, Laura Giusti, Laura Bazzichi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of psoriasin (S100A7) with clinical manifestations of systemic sclerosis: is its presence in whole saliva a potential predictor of pulmonary involvement?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Rheumatol (2008)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18634149"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18634149"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Weiping Qin, Lap Ho, Jun Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "S100A7, a novel Alzheimer's disease biomarker with non-amyloidogenic alpha-secretase activity acts via selective promotion of ADAM-10."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0004183"}], "href": "https://doi.org/10.1371/journal.pone.0004183"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19159013"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19159013"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Christoph Schlapbach, Nikhil Yawalkar, Robert E Hunger "}, {"type": "b", "children": [{"type": "t", "text": "Human beta-defensin-2 and psoriasin are overexpressed in lesions of acne inversa."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Acad Dermatol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaad.2008.12.033"}], "href": "https://doi.org/10.1016/j.jaad.2008.12.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19249126"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19249126"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "N R West, P H Watson "}, {"type": "b", "children": [{"type": "t", "text": "S100A7 (psoriasin) is induced by the proinflammatory cytokines oncostatin-M and interleukin-6 in human breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2009.488"}], "href": "https://doi.org/10.1038/onc.2009.488"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20101226"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20101226"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Satyendra Chandra Tripathi, Ajay Matta, Jatinder Kaur, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear S100A7 is associated with poor prognosis in head and neck cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0011939"}], "href": "https://doi.org/10.1371/journal.pone.0011939"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20689826"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20689826"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Ulf Meyer-Hoffert, Alexandra Zimmermann, Manfred Czapp, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Flagellin delivery by Pseudomonas aeruginosa rhamnolipids induces the antimicrobial protein psoriasin in human skin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0016433"}], "href": "https://doi.org/10.1371/journal.pone.0016433"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21283546"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21283546"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "W Erhart, Ö Alkasi, G Brunke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Induction of human β-defensins and psoriasin in vulvovaginal human papillomavirus-associated lesions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Infect Dis (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/infdis/jir079"}], "href": "https://doi.org/10.1093/infdis/jir079"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21730203"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21730203"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Emman Shubbar, Jenny Vegfors, Maria Carlström, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Psoriasin (S100A7) increases the expression of ROS and VEGF and acts through RAGE to promote endothelial cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res Treat (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10549-011-1920-5"}], "href": "https://doi.org/10.1007/s10549-011-1920-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22189627"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22189627"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Carren S Hau, Naoko Kanda, Shinji Noda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Visfatin enhances the production of cathelicidin antimicrobial peptide, human β-defensin-2, human β-defensin-3, and S100A7 in human keratinocytes and their orthologs in murine imiquimod-induced psoriatic skin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajpath.2013.01.044"}], "href": "https://doi.org/10.1016/j.ajpath.2013.01.044"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23499548"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23499548"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Ryuta Muromoto, Toru Hirao, Keisuke Tawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IL-17A plays a central role in the expression of psoriasis signature genes through the induction of IκB-ζ in keratinocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Immunol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/intimm/dxw011"}], "href": "https://doi.org/10.1093/intimm/dxw011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26944069"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26944069"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Anna-Karin Ekman, Jenny Vegfors, Cecilia Bivik Eding, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of Psoriasin (S100A7) Contributes to Dysregulated Differentiation in Psoriasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Derm Venereol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2340/00015555-2596"}], "href": "https://doi.org/10.2340/00015555-2596"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27958610"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27958610"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Wen G Jiang, Gareth Watkins, Anthony Douglas-Jones, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Psoriasin is aberrantly expressed in human breast cancer and is related to clinical outcomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2004)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15201992"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15201992"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Meghan Webb, Ethan D Emberley, Michael Lizardo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression analysis of the mouse S100A7/psoriasin gene in skin inflammation and mammary tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-5-17"}], "href": "https://doi.org/10.1186/1471-2407-5-17"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15717926"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15717926"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Ian Krop, Annette März, Hanna Carlsson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A putative role for psoriasin in breast tumor progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-05-1523"}], "href": "https://doi.org/10.1158/0008-5472.CAN-05-1523"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16357139"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16357139"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Noemi Moubayed, Michael Weichenthal, Jürgen Harder, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Psoriasin (S100A7) is significantly up-regulated in human epithelial skin tumours."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer Res Clin Oncol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00432-006-0164-y"}], "href": "https://doi.org/10.1007/s00432-006-0164-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17136347"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17136347"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Hao Zhang, Yinping Wang, Yue Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and validation of S100A7 associated with lung squamous cell carcinoma metastasis to brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lung Cancer (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lungcan.2007.02.020"}], "href": "https://doi.org/10.1016/j.lungcan.2007.02.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17418446"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17418446"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "G Zhou, T-X Xie, M Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reciprocal negative regulation between S100A7/psoriasin and beta-catenin signaling plays an important role in tumor progression of squamous cell carcinoma of oral cavity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1211015"}], "href": "https://doi.org/10.1038/sj.onc.1211015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18223693"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18223693"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "M Wenghoefer, A Pantelis, T Najafi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene expression of oncogenes, antimicrobial peptides, and cytokines in the development of oral leukoplakia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.tripleo.2009.08.013"}], "href": "https://doi.org/10.1016/j.tripleo.2009.08.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20727496"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20727496"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "M R Morgan, M Jazayeri, A G Ramsay, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Psoriasin (S100A7) associates with integrin β6 subunit and is required for αvβ6-dependent carcinoma cell invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2010.535"}], "href": "https://doi.org/10.1038/onc.2010.535"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21132011"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21132011"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Yadwinder S Deol, Mohd W Nasser, Lianbo Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor-suppressive effects of psoriasin (S100A7) are mediated through the β-catenin/T cell factor 4 protein pathway in estrogen receptor-positive breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.225466"}], "href": "https://doi.org/10.1074/jbc.M111.225466"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22016394"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22016394"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Mohd W Nasser, Zahida Qamri, Yadwinder S Deol, et al. "}, {"type": "b", "children": [{"type": "t", "text": "S100A7 enhances mammary tumorigenesis through upregulation of inflammatory pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-11-0669"}], "href": "https://doi.org/10.1158/0008-5472.CAN-11-0669"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22158945"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22158945"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Lin Ye, Ping-Hui Sun, Tracey A Martin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Psoriasin (S100A7) is a positive regulator of survival and invasion of prostate cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Urol Oncol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.urolonc.2012.05.006"}], "href": "https://doi.org/10.1016/j.urolonc.2012.05.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22694938"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22694938"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Jatinder Kaur, Ajay Matta, Ipshita Kak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "S100A7 overexpression is a predictive marker for high risk of malignant transformation in oral dysplasia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.28473"}], "href": "https://doi.org/10.1002/ijc.28473"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24122701"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24122701"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Gerd G Gauglitz, Daniela Bureik, Stephanie Zwicker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The antimicrobial peptides psoriasin (S100A7) and koebnerisin (S100A15) suppress extracellular matrix production and proliferation of human fibroblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Skin Pharmacol Physiol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000363579"}], "href": "https://doi.org/10.1159/000363579"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25502330"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25502330"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Mohd W Nasser, Nissar Ahmad Wani, Dinesh K Ahirwar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RAGE mediates S100A7-induced breast cancer growth and metastasis by modulating the tumor microenvironment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-14-2161"}], "href": "https://doi.org/10.1158/0008-5472.CAN-14-2161"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25572331"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25572331"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Fabio D'Amico, Evangelia Skarmoutsou, Mariagrazia Granata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "S100A7: A rAMPing up AMP molecule in psoriasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cytokine Growth Factor Rev (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cytogfr.2016.01.002"}], "href": "https://doi.org/10.1016/j.cytogfr.2016.01.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26872860"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26872860"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "Tian Tian, Xukun Li, Zhen Hua, et al. "}, {"type": "b", "children": [{"type": "t", "text": "S100A7 promotes the migration, invasion and metastasis of human cervical cancer cells through epithelial-mesenchymal transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.15329"}], "href": "https://doi.org/10.18632/oncotarget.15329"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28212564"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28212564"}]}, {"type": "r", "ref": 42, "children": [{"type": "t", "text": "L Padilla, S Dakhel, J Adan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "S100A7: from mechanism to cancer therapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2017.283"}], "href": "https://doi.org/10.1038/onc.2017.283"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28825725"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28825725"}]}, {"type": "r", "ref": 43, "children": [{"type": "t", "text": "Mei Lin, Bairong Xia, Ling Qin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "S100A7 Regulates Ovarian Cancer Cell Metastasis and Chemoresistance Through MAPK Signaling and Is Targeted by miR-330-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Cell Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/dna.2017.3953"}], "href": "https://doi.org/10.1089/dna.2017.3953"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29485916"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29485916"}]}, {"type": "r", "ref": 44, "children": [{"type": "t", "text": "Akifumi Mayama, Kiyoshi Takagi, Hiroyoshi Suzuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "OLFM4, LY6D and S100A7 as potent markers for distant metastasis in estrogen receptor-positive breast carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.13770"}], "href": "https://doi.org/10.1111/cas.13770"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30137688"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30137688"}]}, {"type": "r", "ref": 45, "children": [{"type": "t", "text": "Priya Sivadasan, Manoj Kumar Gupta, Gajanan Sathe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Salivary proteins from dysplastic leukoplakia and oral squamous cell carcinoma and their potential for early detection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Proteomics (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jprot.2019.103574"}], "href": "https://doi.org/10.1016/j.jprot.2019.103574"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31706945"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31706945"}]}, {"type": "r", "ref": 46, "children": [{"type": "t", "text": "Zhiliang Lu, Sufei Zheng, Chengming Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "S100A7 as a potential diagnostic and prognostic biomarker of esophageal squamous cell carcinoma promotes M2 macrophage infiltration and angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Transl Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ctm2.459"}], "href": "https://doi.org/10.1002/ctm2.459"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34323409"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34323409"}]}]}]}