SACK1D Gene

Name	scaffolding CK1 anchoring protein D
Description	Enables kinesin binding activity; microtubule binding activity; and protein kinase binding activity. Involved in several processes, including positive regulation of cell cycle G1/S phase transition; protein localization to mitotic spindle; and regulation of intracellular signal transduction. Located in cytosol; intercellular bridge; and mitotic spindle pole. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "t", "text": "<head>\n <meta charset=\"UTF-8\">\n <title>Summary of FAM83D Function</title>\n </head>\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n FAM83D is increasingly recognized as a multifaceted oncogene that is overexpressed in a wide range of human malignancies—including breast cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", hepatocellular carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "and"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", colorectal cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", non‐small cell lung cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "and"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", glioblastoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ", ovarian cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "and gastric cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "—and its elevated expression is generally associated with aggressive clinicopathological features and a poor prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Functionally, multiple independent studies have demonstrated that FAM83D promotes key cellular processes that drive tumor progression. Its overexpression enhances cell proliferation, clonogenicity, migration, invasion and epithelial–mesenchymal transition, while suppression of FAM83D function leads to spindle defects, cell cycle arrest and increased apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " Mechanistically, FAM83D contributes to oncogenesis by modulating the mitotic machinery and by deregulating several signaling pathways. In particular, FAM83D can physically interact with and downregulate tumor suppressors (for example, FBXW7), thereby activating downstream cascades such as the mTOR, MEK/ERK, AKT, PI3K/AKT/mTOR and Wnt/β-catenin pathways"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_fs", "start_ref": "4", "end_ref": "6"}, {"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " These pathways not only drive cell cycle progression but also appear to contribute to therapy resistance and metastasis.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, FAM83D acts as a pivotal regulator of mitosis and genomic stability while engaging multiple oncogenic signaling routes that facilitate tumor development and progression. Its consistent overexpression and the associated aggressive tumor phenotypes across several cancer types underscore its potential as both a prognostic biomarker and a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zeran Wang, Yueyong Liu, Pengju Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FAM83D promotes cell proliferation and motility by downregulating tumor suppressor gene FBXW7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.1581"}], "href": "https://doi.org/10.18632/oncotarget.1581"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24344117"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24344117"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Dong Wang, Sheng Han, Rui Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FAM83D activates the MEK/ERK signaling pathway and promotes cell proliferation in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2015.01.108"}], "href": "https://doi.org/10.1016/j.bbrc.2015.01.108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25646692"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25646692"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Weijia Liao, Weilong Liu, Xing Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of FAM83D affects the proliferation and invasion of hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.4432"}], "href": "https://doi.org/10.18632/oncotarget.4432"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26125229"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26125229"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yu Mu, Hongzhi Zou, Beibei Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FAM83D knockdown regulates proliferation, migration and invasion of colorectal cancer through inhibiting FBXW7/Notch-1 signalling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2017.03.073"}], "href": "https://doi.org/10.1016/j.biopha.2017.03.073"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28407575"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28407575"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Chengtao Yu, Zhuoan Cheng, Shaohua Cui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "circFOXM1 promotes proliferation of non-small cell lung carcinoma cells by acting as a ceRNA to upregulate FAM83D."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-020-01555-5"}], "href": "https://doi.org/10.1186/s13046-020-01555-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32228656"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32228656"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Chunli Yin, Xiaoyan Lin, Yige Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FAM83D promotes epithelial-mesenchymal transition, invasion and cisplatin resistance through regulating the AKT/mTOR pathway in non-small-cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Oncol (Dordr) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13402-020-00494-9"}], "href": "https://doi.org/10.1007/s13402-020-00494-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32006253"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32006253"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Run Shi, Jing Sun, Qi Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of FAM83D promotes malignant phenotypes of lung adenocarcinoma by regulating cell cycle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Cancer Res (2016)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27904773"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27904773"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jubo Wang, Yu Quan, Jian Lv, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of FAM83D displays antitumor effects in glioblastoma via down-regulation of the AKT/Wnt/β-catenin pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Environ Toxicol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/tox.23488"}], "href": "https://doi.org/10.1002/tox.23488"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35150198"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35150198"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Hongtao Zhu, Shuai Diao, Vincent Lim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FAM83D inhibits autophagy and promotes proliferation and invasion of ovarian cancer cells via PI3K/AKT/mTOR pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Biophys Sin (Shanghai) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/abbs/gmz028"}], "href": "https://doi.org/10.1093/abbs/gmz028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30939187"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30939187"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Furong Wang, Sigong Zhang, Yucai Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of family with sequence similarity 83 member D expression enhances cell proliferation and motility via activation of Wnt/β-catenin signaling and predicts poor prognosis in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Manag Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/CMAR.S203082"}], "href": "https://doi.org/10.2147/CMAR.S203082"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31413630"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31413630"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Peter J Walian, Bo Hang, Jian-Hua Mao "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic significance of FAM83D gene expression across human cancer types."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.6620"}], "href": "https://doi.org/10.18632/oncotarget.6620"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26678035"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26678035"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Gongmin Zhu, Hongwei Xia, Qiulin Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An epithelial-mesenchymal transition-related 5-gene signature predicting the prognosis of hepatocellular carcinoma patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-021-01864-5"}], "href": "https://doi.org/10.1186/s12935-021-01864-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33712026"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33712026"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Lokman Varisli "}, {"type": "b", "children": [{"type": "t", "text": "Meta-analysis of the expression of the mitosis-related gene Fam83D."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Lett (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ol.2012.925"}], "href": "https://doi.org/10.3892/ol.2012.925"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23205133"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23205133"}]}]}]}
Synonyms	C20ORF129, FAM83D, DJ616B8.3, CHICA
Proteins	FA83D_HUMAN
NCBI Gene ID	81610
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SACK1D has 6,424 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 112 datasets.

Click the + buttons to view associations for SACK1D from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SACK1D Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SACK1D gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SACK1D gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SACK1D gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SACK1D gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SACK1D gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SACK1D gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SACK1D gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SACK1D gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SACK1D gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SACK1D gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SACK1D protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SACK1D gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SACK1D gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SACK1D gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SACK1D gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of SACK1D gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing SACK1D protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SACK1D protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SACK1D protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SACK1D protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SACK1D protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SACK1D gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SACK1D gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SACK1D gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SACK1D gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of SACK1D protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SACK1D gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving SACK1D gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SACK1D gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SACK1D gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SACK1D gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SACK1D gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SACK1D gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SACK1D gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SACK1D gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SACK1D gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SACK1D from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with SACK1D gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing SACK1D from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of SACK1D gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.