{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent evidence indicates that SAP30‐DT (previously described under the alias MIRE) functions as an oncogenic long noncoding RNA in clear cell renal cell carcinoma. It is transcriptionally upregulated by c-Myc and, in turn, increases the expression of the transcription factor ELF2 by stabilizing its mRNA. Mechanistically, SAP30‐DT facilitates the phase separation of the RNA binding protein hnRNPK, which then binds more efficiently to ELF2 mRNA, leading to its stabilization. This process forms a positive feedback loop, as ELF2 further upregulates SAP30‐DT expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nEmerging from this work is the implication that SAP30‐DT plays a critical role in tumor initiation and progression, offering new insights into c-Myc–driven carcinogenesis. The identification of this long noncoding RNA and its mechanism of action not only broadens our understanding of the molecular biology of clear cell renal cell carcinoma but also highlights a potential target for future therapeutic interventions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Bingyan Li, Bo Yao, Xiaorui Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "c-Myc-induced long noncoding RNA MIRE cooperates with hnRNPK to stabilize ELF2 mRNA and promotes clear cell renal cell carcinogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Gene Ther (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41417-023-00631-0"}], "href": "https://doi.org/10.1038/s41417-023-00631-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37248433"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37248433"}]}]}]}