{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSAP30L‐AS1 is a long non‐coding RNA that is significantly upregulated in prostate cancer tissues and cell lines when compared with noncancerous counterparts. Clinically, higher levels of SAP30L‐AS1 correlate with more aggressive disease features such as increased Gleason scores, advanced pathological T stage, and reduced overall survival, highlighting its potential as a prognostic biomarker in prostate cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFunctionally, experimental findings indicate that overexpression of SAP30L‐AS1 promotes prostate cancer cell proliferation and impedes apoptosis, while its knockdown not only suppresses cell growth in vitro but also reduces xenograft tumor progression in vivo. These discoveries underscore its role as an oncogenic driver in the context of prostate cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistically, SAP30L‐AS1 exerts its tumor‐promoting effects by physically binding to the promoter region of the SAP30L gene and repressing its expression. Rescue experiments confirm that restoring SAP30L expression can counteract the proliferative and anti-apoptotic influences of SAP30L‐AS1, further solidifying the significance of the SAP30L‐AS1/SAP30L axis in prostate cancer pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiangcheng Qin, Weizhi Zhu, Aimei Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA SAP30L-AS1 promotes prostate cancer growth through repressing SAP30L."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2018.12.047"}], "href": "https://doi.org/10.1016/j.gene.2018.12.047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30599235"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30599235"}]}]}]}