{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSATB2‐AS1 is a long non‐coding RNA that displays marked tissue specificity; it is predominantly expressed in normal colorectal tissues but is significantly downregulated in colorectal cancer. These findings suggest a potential role in modulating pathways relevant to colorectal tumorigenesis, although its detailed molecular mechanisms in this context remain to be fully elucidated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nIn contrast, studies in osteosarcoma have revealed an opposite expression pattern for SATB2‐AS1. In osteosarcoma patient samples and cell lines, SATB2‐AS1 is upregulated—with higher levels observed in metastatic tumors—and mechanistic investigations demonstrate that it regulates the cell cycle, enhances cell proliferation and growth, and modulates the translational expression of the SATB2 gene."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n \nMoreover, within the broader landscape of osteosarcoma research, SATB2‐AS1 has emerged as one of the significant long non‐coding RNAs that may serve as an early diagnostic marker and contribute to understanding tumor recurrence. Its inclusion among the critical lncRNAs underscores its potential as both a biomarker and a functional regulator in osteosarcoma development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mu Xu, Xueni Xu, Bei Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SATB2-AS1 inhibits tumor metastasis and affects the tumor immune cell microenvironment in colorectal cancer by regulating SATB2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-019-1063-6"}], "href": "https://doi.org/10.1186/s12943-019-1063-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31492160"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31492160"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Si-Hong Liu, Jian-Wei Zhu, Hui-Hua Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel antisense long non-coding RNA SATB2-AS1 overexpresses in osteosarcoma and increases cell proliferation and growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-017-2953-9"}], "href": "https://doi.org/10.1007/s11010-017-2953-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28190168"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28190168"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Tang Ying, Jin-Ling Dong, Cen Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The lncRNAs RP1-261G23.7, RP11-69E11.4 and SATB2-AS1 are a novel clinical signature for predicting recurrent osteosarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20191251"}], "href": "https://doi.org/10.1042/BSR20191251"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31850493"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31850493"}]}]}]}