SAV1 Gene

Name	salvador family WW domain containing protein 1
Description	WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor. [provided by RefSeq, Aug 2012]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSalvador (SAV1) functions as a critical scaffold and regulatory protein in the Hippo kinase cascade, where it binds directly to MST kinases through conserved SARAH domains to promote MST activation, stabilize complex formation, and ultimately regulate cell proliferation and apoptosis. SAV1 facilitates MST1/2 autophosphorylation and downstream signaling, a process that is enhanced by its structural organization into heterotetramers with MST kinases. Its ability to bind MST kinases and promote their activation has been shown to be essential for MST‐driven apoptotic signaling in diverse settings, underscoring its central role in maintaining tissue homeostasis and limiting unrestrained cell growth."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its canonical role in Hippo signaling, SAV1 contributes to additional cellular processes. It participates in centrosome disjunction through direct interplay with Nek2A and associates with cell adhesion molecules such as KIRREL1, which recruits SAV1 to cell–cell contact sites to reinforce Hippo activation and polarity cues. Moreover, the MST1/2–SAV1 complex is instrumental in promoting ciliogenesis by regulating cilia disassembly machinery, and SAV1’s stability itself is controlled via phosphorylation (e.g., at Ser‐17) and through proteasomal degradation mechanisms mediated by factors like BCL‑2. SAV1 has also been found to interact with mitochondrial proteins and modulate hormone receptor signaling, as evidenced by its role in supporting ligand‐independent activation of estrogen receptor α (ERα)."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of cancer, SAV1 acts as a tumor suppressor by integrating signals from multiple pathways. Its loss or downregulation—observed in high‐grade renal cell carcinoma, colorectal cancer, and other malignancies—is associated with enhanced cell proliferation and survival. SAV1 supports proapoptotic signaling by cooperating with RASSF1A to modulate p73 activity, while it also restrains oncogenic pathways by directly inhibiting Akt activation and by promoting the ubiquitination and degradation of the transcriptional regulator Gli1. Furthermore, post‐transcriptional regulation by miR‑21, m6A modifications, and regulation by RNA‐binding oncoproteins such as MSI2 further contribute to the attenuation of SAV1 expression in tumors. Notably, genetic analyses indicate that, despite its downregulation in several cancers, SAV1 is rarely mutated, suggesting that epigenetic and post‑transcriptional mechanisms are the predominant modes of its dysregulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Bernard A Callus, Anne M Verhagen, David L Vaux "}, {"type": "b", "children": [{"type": "t", "text": "Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1742-4658.2006.05427.x"}], "href": "https://doi.org/10.1111/j.1742-4658.2006.05427.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16930133"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16930133"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xuelai Luo, Zhaoming Li, Qun Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The human WW45 protein enhances MST1-mediated apoptosis in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2009)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19212654"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19212654"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zhao-Ming Li, Wei-Cheng Liu, Shuo Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Overexpression of hSav1 promotes Mst1-induced apoptosis in HeLa cells]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Zhong Liu Za Zhi (2009)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19950692"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19950692"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sung Jun Bae, Lisheng Ni, Adam Osinski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.30278"}], "href": "https://doi.org/10.7554/eLife.30278"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29063833"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29063833"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Leah Cairns, Thao Tran, Brendan H Fowl, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Salvador has an extended SARAH domain that mediates binding to Hippo kinase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA117.000923"}], "href": "https://doi.org/10.1074/jbc.RA117.000923"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29519817"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29519817"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jinsue Song, Hye Rim Hong, Eiki Yamashita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Low pH-driven folding of WW45-SARAH domain leads to stabilization of the WW45-Mst2 complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jb/mvv031"}], "href": "https://doi.org/10.1093/jb/mvv031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25814670"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25814670"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Balca R Mardin, Cornelia Lange, Joanne E Baxter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb2120"}], "href": "https://doi.org/10.1038/ncb2120"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21076410"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21076410"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yeomyung Park, Joonwoo Park, Yonghee Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mammalian MST2 kinase and human Salvador activate and reduce estrogen receptor alpha in the absence of ligand."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Med (Berl) (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00109-010-0698-y"}], "href": "https://doi.org/10.1007/s00109-010-0698-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21104395"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21104395"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Atanu Paul, Stefano Annunziato, Bo Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cell adhesion molecule KIRREL1 is a feedback regulator of Hippo signaling recruiting SAV1 to cell-cell contact sites."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-022-28567-3"}], "href": "https://doi.org/10.1038/s41467-022-28567-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35177623"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35177623"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Miju Kim, Minchul Kim, Mi-Sun Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The MST1/2-SAV1 complex of the Hippo pathway promotes ciliogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms6370"}], "href": "https://doi.org/10.1038/ncomms6370"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25367221"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25367221"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Di Wu, Shian Wu "}, {"type": "b", "children": [{"type": "t", "text": "A conserved serine residue regulates the stability of Drosophila Salvador and human WW domain-containing adaptor 45 through proteasomal degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2013.03.023"}], "href": "https://doi.org/10.1016/j.bbrc.2013.03.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23524264"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23524264"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Xiaolan Li, Xuelai Luo, Zhaoming Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Screening of binding proteins that interact with human Salvador 1 in a human fetal liver cDNA library by the yeast two-hybrid system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-012-1670-4"}], "href": "https://doi.org/10.1007/s11033-012-1670-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22570112"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22570112"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Nam Jin Yoo, Young Hwa Soung, Jong Woo Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutational analysis of salvador gene in human carcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "APMIS (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1034/j.1600-0463.2003.1110601.x"}], "href": "https://doi.org/10.1034/j.1600-0463.2003.1110601.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12969014"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12969014"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Howard Donninger, Nadia Allen, Adrianna Henson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Salvador protein is a tumor suppressor effector of RASSF1A with hippo pathway-independent functions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.214874"}], "href": "https://doi.org/10.1074/jbc.M110.214874"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21489991"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21489991"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Xuelai Luo, Zhaoming Li, Xiaolan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "hSav1 interacts with HAX1 and attenuates its anti-apoptotic effects in MCF-7 breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2011.692"}], "href": "https://doi.org/10.3892/ijmm.2011.692"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21567072"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21567072"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Keiko Matsuura, Chisato Nakada, Mizuho Mashio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of SAV1 plays a role in pathogenesis of high-grade clear cell renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-11-523"}], "href": "https://doi.org/10.1186/1471-2407-11-523"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22185343"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22185343"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Jianwu Jiang, Wei Chang, Yang Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SAV1, regulated by microRNA-21, suppresses tumor growth in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Cell Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1139/bcb-2018-0034"}], "href": "https://doi.org/10.1139/bcb-2018-0034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30681889"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30681889"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Gun Woo Won, Seon Hee Park, Joonwoo Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mammalian Hippo kinase pathway is downregulated by BCL-2 via protein degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.03.015"}], "href": "https://doi.org/10.1016/j.bbrc.2019.03.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30867124"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30867124"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Yao Jiang, Yanqiong Zhang, Janet Y Leung, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "ALKBH5 Promotes Multiple Myeloma Tumorigenicity through inducing m"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "6"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "A-demethylation of SAV1 mRNA and Myeloma Stem Cell Phenotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijbs.64943"}], "href": "https://doi.org/10.7150/ijbs.64943"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35414790"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35414790"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Ting Liu, Wei Guo, Kai Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Smoke-induced SAV1 Gene Promoter Hypermethylation Disrupts YAP Negative Feedback and Promotes Malignant Progression of Non-small Cell Lung Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijbs.73428"}], "href": "https://doi.org/10.7150/ijbs.73428"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35864957"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35864957"}]}]}]}
Synonyms	WW45, SAV
Proteins	SAV1_HUMAN
NCBI Gene ID	60485
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SAV1 has 8,133 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 121 datasets.

Click the + buttons to view associations for SAV1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SAV1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SAV1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SAV1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SAV1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SAV1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SAV1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SAV1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SAV1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SAV1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SAV1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SAV1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SAV1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SAV1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SAV1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SAV1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SAV1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SAV1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SAV1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of SAV1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SAV1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SAV1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SAV1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SAV1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SAV1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SAV1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SAV1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with SAV1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of SAV1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SAV1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SAV1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SAV1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SAV1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SAV1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SAV1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SAV1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SAV1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SAV1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SAV1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of SAV1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with SAV1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing SAV1 from the GeneSigDB Published Gene Signatures dataset.