{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe study indicates that SCAMP1‐AS1 functions as an oncogenic long non‐coding RNA in glioma. It is markedly up‐regulated in malignant glioma cells, where it acts as a molecular sponge for miR‑499a‑5p—a microRNA that normally suppresses tumor growth. By sequestering miR‑499a‑5p, SCAMP1‑AS1 relieves the microRNA’s inhibitory effect on the transcription factor LMX1A. The subsequent increase in LMX1A levels then up‐regulates NLRC5 expression through direct promoter binding, thereby facilitating the activation of the Wnt/β‑catenin signaling pathway. This cascade of molecular interactions contributes to enhanced proliferation, migration, and invasion, while reducing apoptosis in glioma cells, suggesting that the SCAMP1‑AS1/miR‑499a‑5p/LMX1A/NLRC5 axis could be a promising therapeutic target for glioma treatment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zheqi Zong, Yichen Song, Yixue Xue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of LncRNA SCAMP1 suppressed malignant biological behaviours of glioma cells via modulating miR-499a-5p/LMX1A/NLRC5 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.14362"}], "href": "https://doi.org/10.1111/jcmm.14362"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31207033"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31207033"}]}]}]}