SCAMP5 Gene

HGNC Family	Secretory carrier membrane proteins (SCAMP)
Name	secretory carrier membrane protein 5
Description	Involved in positive regulation of cytokine production; regulation of vesicle-mediated transport; and response to endoplasmic reticulum stress. Located in Golgi apparatus; plasma membrane; and recycling endosome membrane. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSCAMP5 is a brain‐enriched protein that plays a critical role in membrane trafficking and the regulation of vesicle secretion in neurons. Reduced gene dosage of SCAMP5 has been linked to autism, where its silencing correlates with an increase in the secretion of large dense-core vesicles and abnormal granule morphology. In addition, SCAMP5 interacts with the cation/H+ exchanger NHE6 to facilitate its proper localization at glutamatergic presynaptic terminals, thereby modulating vesicle acidity and quantal neurotransmitter release. Moreover, a pathogenic SCAMP5 mutation (R91W) disrupts its interaction with synaptotagmin 1 and likely the SNARE complex, leading to enhanced excitatory synaptic activity and pediatric epilepsy."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of neurodegenerative disease, SCAMP5 expression is upregulated by endoplasmic reticulum stress and mutant huntingtin protein, thereby impairing endocytosis and promoting the formation of ubiquitin‐positive, detergent‐resistant aggregates. This function suggests that SCAMP5 contributes to the pathological accumulation of toxic proteins in Huntington disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in neurons, SCAMP5 is implicated in regulated exocytosis within immune cells. It promotes calcium‐triggered secretion of signal peptide–containing cytokines by rapidly translocating from Golgi compartments to the plasma membrane and interacting with SNARE machinery and synaptotagmins. Consistent with these findings, SCAMP5 is highly expressed in plasmacytoid dendritic cells, where it is associated with type I interferon secretion, and has emerged as a candidate risk gene in autoimmune conditions such as systemic lupus erythematosus."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn oncology, elevated SCAMP5 mRNA levels have been observed in acute myeloid leukemia, where high expression is associated with poor overall survival. This finding suggests that, together with SCAMP2 and SCAMP4, SCAMP5 may serve as a prognostic marker and participate in tumorigenic signaling pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Dries Castermans, Karolien Volders, An Crepel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SCAMP5, NBEA and AMISYN: three candidate genes for autism involved in secretion of large dense-core vesicles."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddq013"}], "href": "https://doi.org/10.1093/hmg/ddq013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20071347"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20071347"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Unghwi Lee, Chunghon Choi, Seung Hyun Ryu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SCAMP5 plays a critical role in axonal trafficking and synaptic localization of NHE6 to adjust quantal size at glutamatergic synapses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.2011371118"}], "href": "https://doi.org/10.1073/pnas.2011371118"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33372133"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33372133"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Dazhi Zhang, Chao Yuan, Mengxue Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deficiency of SCAMP5 leads to pediatric epilepsy and dysregulation of neurotransmitter release in the brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00439-020-02123-9"}], "href": "https://doi.org/10.1007/s00439-020-02123-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32020363"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32020363"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jee-Yeon Noh, Huikyong Lee, Sungmin Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SCAMP5 links endoplasmic reticulum stress to the accumulation of expanded polyglutamine protein aggregates via endocytosis inhibition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M807620200"}], "href": "https://doi.org/10.1074/jbc.M807620200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19240033"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19240033"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Chaofeng Han, Taoyong Chen, Mingjin Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human SCAMP5, a novel secretory carrier membrane protein, facilitates calcium-triggered cytokine secretion by interaction with SNARE machinery."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.0802002"}], "href": "https://doi.org/10.4049/jimmunol.0802002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19234194"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19234194"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Mustafa H Ghanem, Andrew J Shih, Himanshu Vashistha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Investigations into "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "SCAMP5,"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " a candidate lupus risk gene expressed in plasmacytoid dendritic cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lupus Sci Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/lupus-2021-000567"}], "href": "https://doi.org/10.1136/lupus-2021-000567"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34728555"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34728555"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Juliëtte N Pouw, Michel A M Olde Nordkamp, Tom G O'Toole, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation-induced colocalisation of SCAMP5 with IFNα in human plasmacytoid dendritic cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lupus Sci Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/lupus-2022-000680"}], "href": "https://doi.org/10.1136/lupus-2022-000680"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35296555"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35296555"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Can Yue, Siting Xie, Jiaying Zhong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SCAMP2/5 as diagnostic and prognostic markers for acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-96440-2"}], "href": "https://doi.org/10.1038/s41598-021-96440-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34426610"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34426610"}]}]}]}
Proteins	SCAM5_HUMAN
NCBI Gene ID	192683
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SCAMP5 has 5,777 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 107 datasets.

Click the + buttons to view associations for SCAMP5 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SCAMP5 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SCAMP5 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SCAMP5 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SCAMP5 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SCAMP5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SCAMP5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SCAMP5 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SCAMP5 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SCAMP5 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SCAMP5 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SCAMP5 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SCAMP5 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SCAMP5 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SCAMP5 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SCAMP5 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SCAMP5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SCAMP5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with SCAMP5 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SCAMP5 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SCAMP5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SCAMP5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SCAMP5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SCAMP5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SCAMP5 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SCAMP5 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SCAMP5 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SCAMP5 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SCAMP5 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SCAMP5 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SCAMP5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SCAMP5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SCAMP5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SCAMP5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SCAMP5 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SCAMP5 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SCAMP5 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SCAMP5 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of SCAMP5 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with SCAMP5 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing SCAMP5 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of SCAMP5 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.