{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough none of the provided abstracts directly investigate or detail the biological role of SCAND3, together they offer insights into the functions of genes with related domains that may help guide hypotheses about SCAND3. For example, one study exploring the genetic underpinnings of blood pressure regulation identified several loci—such as those near ZBED9, ABHD17C, and FBN1—that influence cardiovascular traits, yet no robust evidence was offered regarding the function of SCAND3 in this context."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " \n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, another abstract focused on a SCAN domain‐containing zinc‐finger protein, ZNF452, which, when overexpressed, promoted tumor cell proliferation, migration, and invasion in non–small cell lung cancer through activation of the AKT–GSK3β signaling pathway. While ZNF452 and SCAND3 share the common feature of the SCAN domain—a motif implicated in protein–protein interactions and transcriptional regulation—the precise cellular or molecular functions of SCAND3 were not delineated. Consequently, inferences regarding SCAND3 must be drawn from its domain architecture and similarities to related proteins like ZNF452."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " \n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA third abstract underscored the complexity of the genetic basis of hypertension, emphasizing the need for epistasis analysis to fully understand interacting genetic components. Although this study did not focus on SCAND3, its discussion of multifactorial influences on diseases such as hypertension suggests that if SCAND3 is functionally connected to other SCAN domain proteins or signaling pathways, its potential role in modulating complex traits and disease phenotypes remains an open avenue for research."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Goodarz Kolifarhood, Siamak Sabour, Mahdi Akbarzadeh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study on blood pressure traits in the Iranian population suggests ZBED9 as a new locus for hypertension."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-90925-w"}], "href": "https://doi.org/10.1038/s41598-021-90925-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34083597"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34083597"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiupeng Zhang, Haijing Zhou, Yong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZNF452 facilitates tumor proliferation and invasion via activating AKT-GSK3β signaling pathway and predicts poor prognosis of non-small cell lung cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.16408"}], "href": "https://doi.org/10.18632/oncotarget.16408"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28418919"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28418919"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mahdi Akbarzadeh, Parisa Riahi, Goodarz Kolifarhood, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The AGT epistasis pattern proposed a novel role for ZBED9 in regulating blood pressure: Tehran Cardiometabolic genetic study (TCGS)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2022.146560"}], "href": "https://doi.org/10.1016/j.gene.2022.146560"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35577038"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35577038"}]}]}]}