SCARB2 Gene

Name	scavenger receptor class B, member 2
Description	The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSCARB2 functions as a critical receptor for several enteroviruses, notably enterovirus 71 (EV71) and coxsackievirus A16 (CVA16), mediating viral attachment, internalization, and pH‐dependent uncoating. Structural and mutagenesis studies have defined key residues—such as those between positions 144 and 151 and specific determinants in the VP1 region—that underpin its ability to bind and trigger conformational changes in the viral capsid, including opening of a lipid‐transfer tunnel to expel a hydrophobic pocket factor. In addition, SCARB2 initiates clathrin‐mediated endocytosis, and transgenic mouse models expressing human SCARB2 recapitulate the neurological and systemic manifestations observed in EV71 infection."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role as a viral receptor, SCARB2—also known as LIMP-2—is indispensable for proper lysosomal function as the sorting receptor for β-glucocerebrosidase (GCase). Mutations in SCARB2 disrupt GCase trafficking, leading to inefficient lysosomal delivery and substrate accumulation, which underlies the pathogenesis of action myoclonus-renal failure (AMRF) syndrome. Detailed analyses have revealed that an intact coiled-coil domain and critical residues (for example, a specific histidine) are essential for binding GCase, thereby influencing phenotypes that span progressive myoclonus epilepsy, varying degrees of renal impairment, and even modifier effects in Gaucher and Parkinson’s disease."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, emerging evidence indicates that SCARB2 contributes to lipid homeostasis by transporting cholesterol and phospholipids within lysosomal compartments and may influence innate immune responses. High expression of SCARB2 in plasmacytoid dendritic cells has been linked to proper Toll-like receptor trafficking and type I interferon production, while genetic studies have implicated SCARB2 variations in the risk of neurodegenerative disorders such as dementia with Lewy bodies and Parkinson’s disease. Together, these findings position SCARB2 as a multifunctional lysosomal protein, central not only to pathogen entry but also to enzyme trafficking, lipid regulation, and immune as well as neurodegenerative pathways."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Seiya Yamayoshi, Yasuko Yamashita, Jifen Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Scavenger receptor B2 is a cellular receptor for enterovirus 71."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.1992"}], "href": "https://doi.org/10.1038/nm.1992"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19543282"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19543282"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Seiya Yamayoshi, Satoshi Koike "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a human SCARB2 region that is important for enterovirus 71 binding and infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.02358-10"}], "href": "https://doi.org/10.1128/JVI.02358-10"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21389126"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21389126"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Pan Chen, Zilin Song, Yonghe Qi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular determinants of enterovirus 71 viral entry: cleft around GLN-172 on VP1 protein interacts with variable region on scavenge receptor B 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.301622"}], "href": "https://doi.org/10.1074/jbc.M111.301622"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22219187"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22219187"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Seiya Yamayoshi, Setsuko Iizuka, Teruo Yamashita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human SCARB2-dependent infection by coxsackievirus A7, A14, and A16 and enterovirus 71."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00020-12"}], "href": "https://doi.org/10.1128/JVI.00020-12"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22438546"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22438546"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ken Fujii, Noriyo Nagata, Yuko Sato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transgenic mouse model for the study of enterovirus 71 neuropathogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1217563110"}], "href": "https://doi.org/10.1073/pnas.1217563110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23959904"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23959904"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xuyuan Zhang, Pan Yang, Nan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Protein Cell (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13238-017-0405-7"}], "href": "https://doi.org/10.1007/s13238-017-0405-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28447294"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28447294"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ting-Yu Yen, Wei-Liang Shih, Yi-Chuan Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms in enterovirus 71 receptors associated with susceptibility and clinical severity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0206769"}], "href": "https://doi.org/10.1371/journal.pone.0206769"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30395634"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30395634"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Daming Zhou, Yuguang Zhao, Abhay Kotecha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Microbiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41564-018-0319-z"}], "href": "https://doi.org/10.1038/s41564-018-0319-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30531980"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30531980"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Samuel F Berkovic, Leanne M Dibbens, Alicia Oshlack, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Array-based gene discovery with three unrelated subjects shows SCARB2/LIMP-2 deficiency causes myoclonus epilepsy and glomerulosclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2007.12.019"}], "href": "https://doi.org/10.1016/j.ajhg.2007.12.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18308289"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18308289"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "L M Dibbens, R Michelucci, A Gambardella, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Progressive myoclonus epilepsy with nephropathy C1q due to SCARB2/LIMP-2 deficiency: clinical report of two siblings."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Seizure (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.seizure.2011.06.018"}], "href": "https://doi.org/10.1016/j.seizure.2011.06.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21782476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21782476"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Arash Velayati, John DePaolo, Nidhi Gupta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A mutation in SCARB2 is a modifier in Gaucher disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.21566"}], "href": "https://doi.org/10.1002/humu.21566"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21796727"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21796727"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Guido Rubboli, Silvana Franceschetti, Samuel F Berkovic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical and neurophysiologic features of progressive myoclonus epilepsy without renal failure caused by SCARB2 mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epilepsia (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1528-1167.2011.03307.x"}], "href": "https://doi.org/10.1111/j.1528-1167.2011.03307.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22050460"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22050460"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Ashley Gonzalez, Mark Valeiras, Ellen Sidransky, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lysosomal integral membrane protein-2: a new player in lysosome-related pathology."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Metab (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymgme.2013.12.005"}], "href": "https://doi.org/10.1016/j.ymgme.2013.12.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24389070"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24389070"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Marsha Zeigler, Vardiella Meiner, J P Newman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel SCARB2 mutation in progressive myoclonus epilepsy indicated by reduced β-glucocerebrosidase activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurol Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jns.2014.01.022"}], "href": "https://doi.org/10.1016/j.jns.2014.01.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24485911"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24485911"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Erika Malini, Stefania Zampieri, Marta Deganuto, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddu334"}], "href": "https://doi.org/10.1093/hmg/ddu334"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24973356"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24973356"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Michelle Rothaug, Friederike Zunke, Joseph R Mazzulli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1405700111"}], "href": "https://doi.org/10.1073/pnas.1405700111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25316793"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25316793"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Hao Guo, Jialong Zhang, Xuyuan Zhang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-017-02044-8"}], "href": "https://doi.org/10.1038/s41467-017-02044-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29199275"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29199275"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Saskia Heybrock, Kristiina Kanerva, Ying Meng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-019-11425-0"}], "href": "https://doi.org/10.1038/s41467-019-11425-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31387993"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31387993"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Ria Thomas, Elizabeth B Moloney, Zachary K Macbain, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fibroblasts from idiopathic Parkinson's disease exhibit deficiency of lysosomal glucocerebrosidase activity associated with reduced levels of the trafficking receptor LIMP2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Brain (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13041-020-00712-3"}], "href": "https://doi.org/10.1186/s13041-020-00712-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33468204"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33468204"}]}]}]}
Synonyms	SR-BII, LGP85, LIMP-2, HLGP85, CD36L2, LIMPII, AMRF, EPM4
Proteins	SCRB2_HUMAN
NCBI Gene ID	950
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SCARB2 has 13,282 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 136 datasets.

Click the + buttons to view associations for SCARB2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SCARB2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SCARB2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SCARB2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SCARB2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SCARB2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SCARB2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SCARB2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SCARB2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SCARB2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SCARB2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SCARB2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SCARB2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SCARB2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SCARB2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SCARB2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SCARB2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SCARB2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SCARB2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with SCARB2 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with SCARB2 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of SCARB2 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SCARB2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SCARB2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SCARB2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing SCARB2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing SCARB2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SCARB2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SCARB2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SCARB2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SCARB2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SCARB2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SCARB2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with SCARB2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of SCARB2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SCARB2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving SCARB2 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving SCARB2 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with SCARB2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SCARB2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SCARB2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SCARB2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.