{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLncRNA SCARNA10 has emerged as a key regulator in hepatic fibrogenesis. Notably, its expression is markedly up-regulated in both patient samples with advanced liver fibrosis and in mouse fibrosis models, and it promotes fibrosis by inducing hepatocyte apoptosis and activating hepatic stellate cells. Mechanistically, SCARNA10 exerts its pro-fibrotic effects by physically associating with the polycomb repressive complex 2 (PRC2), thereby inhibiting PRC2 recruitment to the promoters of extracellular matrix and TGFβ pathway genes, which leads to enhanced transcription of these genes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nIn addition to its role in liver fibrosis, circulating SCARNA10 has been explored as a potential diagnostic biomarker for hepatocellular carcinoma, suggesting its utility in the early detection or monitoring of liver cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n\nMoreover, SCARNA10 has been identified as a novel regulator of the tumor suppressor p53. It interacts directly with the DNA binding domain of p53 and the CREB-binding protein, promoting p53 acetylation and thereby enhancing p53-mediated transcriptional activation without altering overall p53 protein levels. Through this mechanism, SCARNA10 facilitates p53-dependent tumor suppression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kun Zhang, Yawei Han, Zhimei Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SCARNA10, a nuclear-retained long non-coding RNA, promotes liver fibrosis and serves as a potential biomarker."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Theranostics (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/thno.32935"}], "href": "https://doi.org/10.7150/thno.32935"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31281502"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31281502"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yawei Han, Wenna Jiang, Yu Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serum long non-coding RNA SCARNA10 serves as a potential diagnostic biomarker for hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-022-09530-3"}], "href": "https://doi.org/10.1186/s12885-022-09530-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35443674"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35443674"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yanxia Wu, Yanxi Sun, Binchu Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SCARNA10 regulates p53 acetylation-dependent transcriptional activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2023.05.091"}], "href": "https://doi.org/10.1016/j.bbrc.2023.05.091"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37262951"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37262951"}]}]}]}