{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have expanded our understanding of snoRNAs by revealing that some members of this RNA family, such as ACA45, undergo Dicer‐dependent processing to generate small RNA species that can associate with Argonaute proteins and act like microRNAs. In the report by Yang et al"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", the snoRNA ACA45 is processed independently of the Drosha/DGCR8 complex, and its small RNA products were shown to target mRNAs—exemplified by the mediator subunit CDC2L6—thus implicating a role in posttranscriptional gene silencing."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Discerning a broader landscape of snoRNA functionality, the study also notes that additional snoRNAs exhibit miRNA‐like processing signatures. Although the work primarily centers on ACA45, such processing patterns raise the possibility that SCARNA15—a small Cajal body–specific RNA—may similarly be processed into regulatory small RNAs. This suggests that, beyond its canonical role in guiding chemical modifications within the Cajal body, SCARNA15 might participate in the modulation of mRNA stability and translation through incorporation into Argonaute complexes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Collectively, these insights propose a dual functional model for select snoRNAs, including SCARNA15, wherein they serve both in RNA modification processes and as sources for small regulatory RNAs that influence gene expression posttranscriptionally. This expanding role for snoRNAs underscores the dynamic interplay between RNA processing mechanisms and gene regulatory networks."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Christine Ender, Azra Krek, Marc R Friedländer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A human snoRNA with microRNA-like functions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2008.10.017"}], "href": "https://doi.org/10.1016/j.molcel.2008.10.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19026782"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19026782"}]}]}]}