{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSCARNA2 is a long noncoding RNA that has been implicated in the clinical behavior of colorectal cancer, where it is highly expressed in tumor tissues relative to adjacent normal tissues. Its overexpression is associated with an unfavorable postoperative prognosis, as SCARNA2 confers chemoresistance by acting as a competing endogenous RNA. In this role, it sequesters miR-342-3p, which in turn facilitates the upregulation of key survival and proliferation factors such as epidermal growth factor receptor (EGFR) and B-cell lymphoma 2 (BCL2) in colorectal cancer cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a distinct functional context, SCARNA2 belongs to the family of C/D box small Cajal body-specific RNAs that guide the site-specific 2′-O-methylation of U2 snRNA, a modification essential for proper splicing. Unlike many other small Cajal body-specific RNAs, SCARNA2 is independently transcribed by RNA polymerase II. Its transcription is regulated by a compact promoter region containing a TATA motif, a binding site for the transcription factor hStaf/ZNF143, and additional conserved promoter elements, underscoring a unique maturation pathway that differs from that of typical mRNAs or snRNAs."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nWhile these studies highlight the dual roles of SCARNA2 in modulating chemoresistance and RNA modification processes, its expression pattern and potential functions in other tumor types, such as cutaneous squamous cell carcinoma, remain uncharacterized, indicating an important area for future research."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Peng-Fei Zhang, Jing Wu, Yin Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The lncRNA SCARNA2 mediates colorectal cancer chemoresistance through a conserved microRNA-342-3p target sequence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.27684"}], "href": "https://doi.org/10.1002/jcp.27684"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30443961"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30443961"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Marie-Aline Gérard, Evelyne Myslinski, Natassia Chylak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The scaRNA2 is produced by an independent transcription unit and its processing is directed by the encoding region."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkp988"}], "href": "https://doi.org/10.1093/nar/gkp988"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19906720"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19906720"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zhongzhao Zhang, Min Jia, Changhui Wen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA SCARNA2 induces cutaneous squamous cell carcinoma progression via modulating miR-342-3p expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gene Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jgm.3242"}], "href": "https://doi.org/10.1002/jgm.3242"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32558970"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32558970"}]}]}]}