{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies indicate that the long noncoding RNA SCIRT plays a multifaceted role in regulating pathological processes. Under ischemia-reperfusion injury conditions, mimicked by hypoxia-reoxygenation in endothelial cells, SCIRT expression is significantly increased and shows a strong correlation with the angiogenesis marker VEGFA. Mechanistically, SCIRT enhances the stability of VEGFA mRNA through posttranscriptional regulation, achieved by modulating the activity of the RNA-binding protein HuR – a protein which binds and protects VEGFA mRNA from degradation by inhibiting its ubiquitination. This regulatory mechanism underlies the promotion of endothelial angiogenesis in stress conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nDisruptions in SCIRT function may also contribute to oncogenic processes. In the context of oral squamous cell carcinoma, SCIRT has been predicted to interact with miR-221, thereby affecting the expression of lncRNA GAS5. While SCIRT has been previously noted for its tumor-suppressive role in breast cancer, these findings suggest that SCIRT may similarly influence tumor biology in OSCC by modulating oncogenic microRNAs and their targets."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n\nMoreover, emerging evidence implicates SCIRT in modulating inflammatory processes associated with atherosclerosis. In this disease context, SCIRT appears to interact with miR-146a, a microRNA involved in inflammatory signaling, suggesting that SCIRT might regulate vascular inflammation and atherosclerotic progression. These observations expand the functional repertoire of SCIRT beyond cancer, implicating it as a key regulatory RNA in diverse human diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lianze Gao, Jihong Yang, Yi Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA SCIRT Promotes HUVEC Angiogenesis via Stabilizing VEGFA mRNA Induced by Hypoxia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oxid Med Cell Longev (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/9102978"}], "href": "https://doi.org/10.1155/2022/9102978"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35698607"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35698607"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lei Yang, Kaicheng Yang, Huichao Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SCIRT absorbs miR-221 to advance the expression of lncRNA GAS5 in oral squamous cell carcinoma to inhibit cancer cell apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Oral Pathol Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jop.13241"}], "href": "https://doi.org/10.1111/jop.13241"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34547134"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34547134"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wenhui Gao, Rong Li, Jingjing Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SCIRT is downregulated in atherosclerosis and suppresses the proliferation of human aortic smooth muscle cells (HAOSMCs) by sponging miR-146a in cytoplasm."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cardiothorac Surg (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13019-021-01700-x"}], "href": "https://doi.org/10.1186/s13019-021-01700-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34742341"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34742341"}]}]}]}