{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent evidence has revealed that long non‐coding RNAs (lncRNAs) act as promising biomarkers for cardiovascular traits, including salt sensitivity of blood pressure (SSBP). In a study involving both hypertensive and normotensive individuals, SCOC‑AS1 was identified among several lncRNAs that were differentially expressed between salt‐sensitive and salt‐resistant subjects. Notably, when analyzed independently, SCOC‑AS1 demonstrated a strong diagnostic performance in normotensive individuals, suggesting its potential role as a genetic susceptibility marker for SSBP in this subgroup."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, when SCOC‑AS1 was combined with other lncRNAs—specifically lnc‑IGSF3‑1:1 and SLC8A1‑AS1—the multi‐lncRNA panel achieved improved diagnostic accuracy for both hypertensive and normotensive groups. While subsequent bioinformatic analyses identified lnc‑IGSF3‑1:1 and SLC8A1‑AS1 as central hub biomarkers within a lncRNA‐mRNA network, SCOC‑AS1’s role remains significant, especially in refining the detection of salt sensitivity among normotensive individuals."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wenjuan Peng, Yunyi Xie, Juan Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of Circulating Biomarkers of lnc-IGSF3-1:1, SCOC-AS1, and SLC8A1-AS1 with Salt Sensitivity of Blood Pressure in Chinese Population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cardiovasc Transl Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12265-021-10190-0"}], "href": "https://doi.org/10.1007/s12265-021-10190-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34855149"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34855149"}]}]}]}