{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that the long non‐coding RNA SDCBP2‑AS1 is intricately involved in cancer progression. In ovarian cancer, SDCBP2‑AS1 plays a role in tumor development by modulating the miR‑100‑5p/EPDR1 signaling axis, while in gastric cancer it appears to contribute to tumorigenesis and progression through mechanisms that may involve lncRNA‐mediated post‑translational modifications."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn lung cancer, SDCBP2‑AS1 is markedly upregulated and functions as a competing endogenous RNA by sponging miR‑656‑3p, which in turn modulates the expression of CRIM1. This regulatory interaction is critical for controlling ferroptosis—a form of regulated cell death—as depletion of SDCBP2‑AS1 leads to enhanced ferroptosis, indicated by increased cell death, higher reactive oxygen species levels, and disrupted expression of ferroptosis markers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, these findings underscore the multifaceted roles of SDCBP2‑AS1 in distinct cancer types, highlighting its involvement in key regulatory networks that govern tumor growth and cell death. The convergence of its activities in ovarian, gastric, and lung cancers not only enhances our understanding of cancer biology but also signals the potential of SDCBP2‑AS1 as a promising biomarker and therapeutic target for tailored cancer interventions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiu Liu, Chanyuan Liu, Aijun Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA SDCBP2-AS1 delays the progression of ovarian cancer via microRNA-100-5p-targeted EPDR1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Surg Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12957-021-02295-2"}], "href": "https://doi.org/10.1186/s12957-021-02295-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34218800"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34218800"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jing Han, Menglin Nie, Cong Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SDCBP-AS1 destabilizes β-catenin by regulating ubiquitination and SUMOylation of hnRNP K to suppress gastric tumorigenicity and metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Commun (Lond) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cac2.12367"}], "href": "https://doi.org/10.1002/cac2.12367"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36209503"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36209503"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ninghuang Dai, Haitao Ma, Yu Feng "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of long non-coding RNA SDCBP2-AS1/microRNA-656-3p/CRIM1 axis promotes ferroptosis of lung cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol (Noisy-le-grand) (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14715/cmb/2023.69.9.29"}], "href": "https://doi.org/10.14715/cmb/2023.69.9.29"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37807311"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37807311"}]}]}]}