SEC23A Gene

Name	Sec23 homolog A (S. cerevisiae)
Description	The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSEC23A is a core component of the COPII complex that mediates protein export from the endoplasmic reticulum (ER) to the Golgi apparatus. Structural and biochemical studies have demonstrated that SEC23A, in complex with SEC24, plays a critical role in cargo selection and coat assembly."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Transcriptional modulation by factors such as BBF2H7 supports procollagen trafficking through upregulation of SEC23A, underscoring its importance in the secretion of extracellular matrix proteins."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In addition, specific interactions with ER export signal motifs—for example, those identified in a bovine anion exchanger model—demonstrate its role in selective cargo recognition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Under conditions of ER stress, impaired membrane association of SEC23A further highlights the dynamic regulation of this protein in secretory trafficking"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", while its functional equivalence to its paralog SEC23B has been confirmed through rescue experiments in model systems."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n \n \nSEC23A dysregulation has significant implications in human disease. In prostate carcinoma, for instance, oncogenic microRNAs such as miR-375 target the 3′‐UTR of SEC23A, leading to decreased protein expression and enhanced tumor cell growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Similarly, in medullary thyroid carcinoma, miR-375–mediated downregulation of SEC23A is associated with increased sensitivity to therapeutic agents."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Genetic association studies have further linked SEC23A variants to alterations in serum vitamin D levels, suggesting a broader metabolic role."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Moreover, modulation of SEC23A by miR-29b-3p in endothelial cells has been shown to attenuate inflammatory injury, indicating a role in vascular homeostasis and potential sepsis management."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Its involvement in cancer is further supported by observations in gastric cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", and pathogenic mutations in SEC23A cause cranio-lenticulo-sutural dysplasia, a disorder characterized by skeletal dysmorphism and cataracts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiping Bi, Joseph D Mancias, Jonathan Goldberg "}, {"type": "b", "children": [{"type": "t", "text": "Insights into COPII coat nucleation from the structure of Sec23.Sar1 complexed with the active fragment of Sec31."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devcel.2007.10.006"}], "href": "https://doi.org/10.1016/j.devcel.2007.10.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17981133"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17981133"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Seiko Ishikura-Kinoshita, Hiroshi Saeki, Kentaro Tsuji-Naito "}, {"type": "b", "children": [{"type": "t", "text": "BBF2H7-mediated Sec23A pathway is required for endoplasmic reticulum-to-Golgi trafficking in dermal fibroblasts to promote collagen synthesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jid.2012.103"}], "href": "https://doi.org/10.1038/jid.2012.103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22495181"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22495181"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wataru Otsu, Takao Kurooka, Yayoi Otsuka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A new class of endoplasmic reticulum export signal PhiXPhiXPhi for transmembrane proteins and its selective interaction with Sec24C."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.443325"}], "href": "https://doi.org/10.1074/jbc.M112.443325"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23658022"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23658022"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Giuseppina Amodio, Rossella Venditti, Maria Antonietta De Matteis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endoplasmic reticulum stress reduces COPII vesicle formation and modifies Sec23a cycling at ERESs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2013.08.021"}], "href": "https://doi.org/10.1016/j.febslet.2013.08.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23994533"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23994533"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Rami Khoriaty, Geoffrey G Hesketh, Amélie Bernard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1805784115"}], "href": "https://doi.org/10.1073/pnas.1805784115"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30065114"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30065114"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jaroslaw Szczyrba, Elke Nolte, Sven Wach, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of Sec23A protein by miRNA-375 in prostate carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-10-0573"}], "href": "https://doi.org/10.1158/1541-7786.MCR-10-0573"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21593139"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21593139"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Sandra Lassalle, Joséphine Zangari, Alexandra Popa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-375/SEC23A as biomarkers of the in vitro efficacy of vandetanib."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.8458"}], "href": "https://doi.org/10.18632/oncotarget.8458"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27036030"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27036030"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xia Jiang, Paul F O'Reilly, Hugues Aschard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-017-02662-2"}], "href": "https://doi.org/10.1038/s41467-017-02662-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29343764"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29343764"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yiqing Tong, Ziyang Zhou, Jianguo Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-29b-3p Inhibits the Inflammation Injury in Human Umbilical Vein Endothelial Cells by Regulating SEC23A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Genet (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10528-022-10194-8"}], "href": "https://doi.org/10.1007/s10528-022-10194-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35190931"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35190931"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Quan Cheng, Kanghui Liu, Jian Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SEC23A confers ER stress resistance in gastric cancer by forming the ER stress-SEC23A-autophagy negative feedback loop."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-023-02807-w"}], "href": "https://doi.org/10.1186/s13046-023-02807-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37670384"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37670384"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Qiwei Wang, Xiaoshan Lin, Kunbei Lai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel compound heterozygous variants of the SEC23A gene in a Chinese family with cranio-lenticulo-sutural dysplasia based on data from a large cohort of congenital cataract patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Med Genomics (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12920-023-01667-9"}], "href": "https://doi.org/10.1186/s12920-023-01667-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37828500"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37828500"}]}]}]}
Synonyms	CLSD, hSec23A
Proteins	SC23A_HUMAN
NCBI Gene ID	10484
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SEC23A has 10,202 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 128 datasets.

Click the + buttons to view associations for SEC23A from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SEC23A Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by SEC23A gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SEC23A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SEC23A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SEC23A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SEC23A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SEC23A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SEC23A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SEC23A gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SEC23A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SEC23A gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SEC23A gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SEC23A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SEC23A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SEC23A protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SEC23A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SEC23A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SEC23A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with SEC23A gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with SEC23A gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SEC23A gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SEC23A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SEC23A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing SEC23A protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SEC23A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SEC23A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SEC23A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SEC23A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SEC23A gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SEC23A gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of SEC23A protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SEC23A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with SEC23A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SEC23A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SEC23A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SEC23A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SEC23A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SEC23A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SEC23A gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SEC23A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SEC23A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.