| Name | selenoprotein F |
| Description | The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. It has also been suggested to have a role in cancer etiology. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2016] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSELENOF, formerly known as SEP15, is an endoplasmic reticulum–resident selenoprotein defined by a thioredoxin‐like domain that harbors a unique redox-active CXU motif. Detailed chemical synthesis studies have demonstrated that its redox potential is comparable to that of thiol–disulfide oxidoreductases, indicating that SELENOF can reduce non-native disulfide bonds in misfolded proteins and thereby contribute to protein quality control in the ER—even though it does not act as a classical protein disulfide isomerase."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the cellular level, perturbations in SELENOF expression substantially alter cell behavior. In liver cell models, RNAi-mediated knockdown of SELENOF (SEP15) provokes dynamic non-apoptotic membrane blebbing, reorganization of actin fibers, and a redistribution of focal adhesions that coincides with G1 phase cell cycle arrest via upregulation of p21 and p27. In addition, SELENOF expression is transcriptionally regulated by Heat Shock Factor 1 (HSF1) during selenate and endoplasmic reticulum stress responses, highlighting its integration into cellular stress-adaptation pathways."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nClinically, diminished SELENOF expression and genetic variants affecting its 3′-UTR are linked with more aggressive cancer phenotypes, particularly in prostate and breast tumors. Reduced levels of SELENOF have been associated with enhanced cell migration, anchorage-independent growth, and metabolic reprogramming in prostate cancer, while its polymorphic variants—whose frequencies vary among ethnic groups—may modulate cancer risk and patient outcomes. These findings underscore a potential tumor-suppressive role for SELENOF and support its emerging status as both a biomarker and a therapeutic target in oncology."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Alexandra Zigrossi, Lenny K Hong, Roudy C Ekyalongo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SELENOF is a new tumor suppressor in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-021-02158-w"}], "href": "https://doi.org/10.1038/s41388-021-02158-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35082382"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35082382"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Brenna Flowers, Oliwia Bochnacka, Allison Poles, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct Roles of SELENOF in Different Human Cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomolecules (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/biom13030486"}], "href": "https://doi.org/10.3390/biom13030486"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36979420"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36979420"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jeyoung Bang, Mihyun Jang, Jang Hoe Huh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deficiency of the 15-kDa selenoprotein led to cytoskeleton remodeling and non-apoptotic membrane blebbing through a RhoA/ROCK pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2014.12.059"}], "href": "https://doi.org/10.1016/j.bbrc.2014.12.059"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25529450"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25529450"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jeyoung Bang, Jang Hoe Huh, Ji-Woon Na, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cell Proliferation and Motility Are Inhibited by G1 Phase Arrest in 15-kDa Selenoprotein-Deficient Chang Liver Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cells (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14348/molcells.2015.0007"}], "href": "https://doi.org/10.14348/molcells.2015.0007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25728752"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25728752"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Bingyu Ren, Yanmei Huang, Chen Zou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional Regulation of Selenoprotein F by Heat Shock Factor 1 during Selenium Supplementation and Stress Response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells8050479"}], "href": "https://doi.org/10.3390/cells8050479"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31109102"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31109102"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Dede N Ekoue, Emmanuel Ansong, Li Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Correlations of SELENOF and SELENOP genotypes with serum selenium levels and prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prostate (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pros.23471"}], "href": "https://doi.org/10.1002/pros.23471"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29314169"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29314169"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Lenny K Hong, Shrinidhi Kadkol, Maria Sverdlov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of SELENOF Induces the Transformed Phenotype in Human Immortalized Prostate Epithelial Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms222112040"}], "href": "https://doi.org/10.3390/ijms222112040"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34769469"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34769469"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Soumen Bera, Alan M Diamond "}, {"type": "b", "children": [{"type": "t", "text": "Role of SELENBP1 and SELENOF in prostate cancer bioenergetics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Biochem Biophys (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.abb.2022.109451"}], "href": "https://doi.org/10.1016/j.abb.2022.109451"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36334799"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36334799"}]}]}]}
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| NCBI Gene ID | 9403 |
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| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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SELENOF has 2,770 functional associations with biological entities spanning 6 categories (chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 40 datasets.
Click the + buttons to view associations for SELENOF from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of SELENOF gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of SELENOF gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| CCLE Cell Line Proteomics | Cell lines associated with SELENOF protein from the CCLE Cell Line Proteomics dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with SELENOF gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of SELENOF gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of SELENOF gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing SELENOF protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 | cellular components containing SELENOF protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with SELENOF protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| DeepCoverMOA Drug Mechanisms of Action | small molecule perturbations with high or low expression of SELENOF protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with SELENOF gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with SELENOF gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with SELENOF gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving SELENOF gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving SELENOF gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing SELENOF protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing SELENOF protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of SELENOF gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of SELENOF gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of SELENOF gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of SELENOF gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of SELENOF gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of SELENOF gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by SELENOF gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of SELENOF gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving SELENOF protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving SELENOF protein from the Wikipathways PFOCR 2024 dataset. | |
| Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of SELENOF gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of SELENOF gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of SELENOF gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of SELENOF gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of SELENOF gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of SELENOF gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Sanger Dependency Map Cancer Cell Line Proteomics | cell lines associated with SELENOF protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset. | |
| Sci-Plex Drug Perturbation Signatures | drug perturbations changing expression of SELENOF gene from the Sci-Plex Drug Perturbation Signatures dataset. | |
| Tahoe Therapeutics Tahoe 100M Perturbation Atlas | drug perturbations changing expression of SELENOF gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of SELENOF protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of SELENOF protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with SELENOF protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2024 | pathways involving SELENOF protein from the WikiPathways Pathways 2024 dataset. | |
