{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSelenoprotein P (SELENOP) is a liver‐derived secretory glycoprotein that plays a central role in whole‐body selenium homeostasis by acting as the major plasma selenium transporter. It facilitates delivery of selenium to extrahepatic tissues—including the brain, kidney, testis, and even the male reproductive tract where its secretion into seminal plasma supports glutathione peroxidase synthesis and sperm viability—thereby ensuring the function of numerous intracellular selenoenzymes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its classic role as a selenium supplier, SELENOP has emerged as an important hepatokine that modulates systemic metabolism. Elevated circulating levels impair insulin signaling, contribute to both insulin and exercise resistance, and are linked to disturbances in adipokine profiles—all of which have been reported in models of obesity and type 2 diabetes. Such metabolic derangements are thought to involve inhibition of AMP‐activated protein kinase activity and other downstream effects that exacerbate glucose intolerance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGenetic polymorphisms affecting the SEPP1 gene and altered SELENOP concentrations have been linked to cancer risk and prognosis. Variants in SEPP1 influence selenium status and the functional integrity of antioxidant selenoenzymes, thereby modulating susceptibility to malignancies such as colorectal, prostate, and breast cancer. In several studies, changes in circulating SELENOP served as a potential biomarker indicative of tumor aggressiveness and poor clinical outcome."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "26"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSELENOP also contributes to neuroprotection and reproductive health. Its local expression in the brain ensures the delivery of selenium for the maintenance of selenoenzyme-based antioxidant defenses, which is critical for neuronal survival and may influence the pathogenesis of neurodegenerative diseases such as Parkinson’s and Alzheimer’s. In parallel, the presence of SELENOP in seminal plasma is essential for effective selenium transfer and the biosynthesis of key antioxidant enzymes in spermatozoa."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "27", "end_ref": "30"}, {"type": "fg_f", "ref": "5"}, {"type": "fg_f", "ref": "31"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nInflammatory mediators and stress signals are key regulators of SELENOP expression. Pro‐inflammatory cytokines, glucocorticoids, and oxidative stress encountered during conditions such as sepsis, pulmonary fibrosis, or inflammatory bowel disease can alter SEPP1 transcription. These dynamic changes suggest that SELENOP not only reflects the systemic selenium status but also actively participates in the acute‐phase response and tissue defense mechanisms."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "32", "end_ref": "36"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRecent advances suggest that SELENOP expression can be modulated by nutritional factors and that novel, highly sensitive assays are now available for its quantification. Dietary components such as serine have been shown to enhance SELENOP (and related selenoenzyme) expression, and comprehensive biomarker assessments reveal significant sex‐specific differences and associations with metabolic syndrome even in pediatric populations. These findings underscore the potential of nutritional interventions to optimize selenium bioavailability and improve clinical outcomes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "37", "end_ref": "40"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn pregnancy, genetic variations in SEPP1 as well as subtle shifts in SELENOP concentrations have been linked to maternal selenium status and the risk of developing conditions such as pre‐eclampsia. This highlights the critical importance of finely tuned SELENOP regulation for ensuring optimal maternal and fetal health."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "41"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Oliver H Al-Taie, Jochen Seufert, Hubert Mörk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A complex DNA-repeat structure within the Selenoprotein P promoter contains a functionally relevant polymorphism and is genetically unstable under conditions of mismatch repair deficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.ejhg.5200811"}], "href": "https://doi.org/10.1038/sj.ejhg.5200811"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12173025"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12173025"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yoshiro Saito, Kazuhiko Takahashi "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of selenoprotein P as a selenium supply protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Biochem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1046/j.1432-1033.2002.03298.x"}], "href": "https://doi.org/10.1046/j.1432-1033.2002.03298.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12423375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12423375"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Catherine Méplan, Lynne K Crosley, Fergus Nicol, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic polymorphisms in the human selenoprotein P gene determine the response of selenoprotein markers to selenium supplementation in a gender-specific manner (the SELGEN study)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.07-8166com"}], "href": "https://doi.org/10.1096/fj.07-8166com"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17536041"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17536041"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kostja Renko, Margarethe Werner, Ingrid Renner-Müller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hepatic selenoprotein P (SePP) expression restores selenium transport and prevents infertility and motor-incoordination in Sepp-knockout mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20071172"}], "href": "https://doi.org/10.1042/BJ20071172"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17961124"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17961124"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Marten Michaelis, Oliver Gralla, Thomas Behrends, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Selenoprotein P in seminal fluid is a novel biomarker of sperm quality."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2013.12.067"}], "href": "https://doi.org/10.1016/j.bbrc.2013.12.067"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24361887"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24361887"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Marco Roman, Annunziata Lapolla, Petru Jitaru, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plasma selenoproteins concentrations in type 2 diabetes mellitus--a pilot study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.trsl.2010.07.006"}], "href": "https://doi.org/10.1016/j.trsl.2010.07.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20875901"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20875901"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Hirofumi Misu, Toshinari Takamura, Hiroaki Takayama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A liver-derived secretory protein, selenoprotein P, causes insulin resistance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Metab (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cmet.2010.09.015"}], "href": "https://doi.org/10.1016/j.cmet.2010.09.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21035759"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21035759"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "S J Yang, S Y Hwang, H Y Choi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serum selenoprotein P levels in patients with type 2 diabetes and prediabetes: implications for insulin resistance, inflammation, and atherosclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2011-0620"}], "href": "https://doi.org/10.1210/jc.2011-0620"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21677040"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21677040"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Hirofumi Misu, Kazuhide Ishikura, Seiichiro Kurita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inverse correlation between serum levels of selenoprotein P and adiponectin in patients with type 2 diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0034952"}], "href": "https://doi.org/10.1371/journal.pone.0034952"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22496878"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22496878"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Tae Woo Jung, So Young Lee, Ho Cheol Hong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AMPK activator-mediated inhibition of endoplasmic reticulum stress ameliorates carrageenan-induced insulin resistance through the suppression of selenoprotein P in HepG2 hepatocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Endocrinol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mce.2013.09.013"}], "href": "https://doi.org/10.1016/j.mce.2013.09.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24055274"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24055274"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jacklyn N Hellwege, Nicholette D Palmer, Julie T Ziegler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variants in selenoprotein P plasma 1 gene (SEPP1) are associated with fasting insulin and first phase insulin response in Hispanics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2013.10.035"}], "href": "https://doi.org/10.1016/j.gene.2013.10.035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24161883"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24161883"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Hiroaki Takayama, Hirofumi Misu, Hisakazu Iwama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Metformin suppresses expression of the selenoprotein P gene via an AMP-activated kinase (AMPK)/FoxO3a pathway in H4IIEC3 hepatocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.479386"}], "href": "https://doi.org/10.1074/jbc.M113.479386"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24257750"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24257750"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Margaret P Rayman, Elizabeth Searle, Lynne Kelly, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of selenium on markers of risk of pre-eclampsia in UK pregnant women: a randomised, controlled pilot trial."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Nutr (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1017/S0007114514000531"}], "href": "https://doi.org/10.1017/S0007114514000531"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24708917"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24708917"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Miaoxin Chen, Bo Liu, David Wilkinson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Selenoprotein P is elevated in individuals with obesity, but is not independently associated with insulin resistance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Obes Res Clin Pract (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.orcp.2016.07.004"}], "href": "https://doi.org/10.1016/j.orcp.2016.07.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27524654"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27524654"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Hirofumi Misu, Hiroaki Takayama, Yoshiro Saito, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.4295"}], "href": "https://doi.org/10.1038/nm.4295"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28263310"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28263310"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Swe Mar Oo, Hirofumi Misu, Yoshiro Saito, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serum selenoprotein P, but not selenium, predicts future hyperglycemia in a general Japanese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-35067-2"}], "href": "https://doi.org/10.1038/s41598-018-35067-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30425271"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30425271"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Yi Chen, Xinjue He, Xueyang Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SeP is elevated in NAFLD and participates in NAFLD pathogenesis through AMPK/ACC pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.30121"}], "href": "https://doi.org/10.1002/jcp.30121"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33094480"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33094480"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Matthew L Cooper, Hans-Olov Adami, Henrik Grönberg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction between single nucleotide polymorphisms in selenoprotein P and mitochondrial superoxide dismutase determines prostate cancer risk."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-08-1827"}], "href": "https://doi.org/10.1158/0008-5472.CAN-08-1827"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19074884"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19074884"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Catherine Méplan, Fergus Nicol, Brian T Burtle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Relative abundance of selenoprotein P isoforms in human plasma depends on genotype, se intake, and cancer status."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Antioxid Redox Signal (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/ARS.2009.2533"}], "href": "https://doi.org/10.1089/ARS.2009.2533"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19453253"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19453253"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Catherine Méplan, David J Hughes, Barbara Pardini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variants in selenoprotein genes increase risk of colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgq076"}], "href": "https://doi.org/10.1093/carcin/bgq076"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20378690"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20378690"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Bodo Speckmann, Antonio Pinto, Meike Winter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proinflammatory cytokines down-regulate intestinal selenoprotein P biosynthesis via NOS2 induction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Free Radic Biol Med (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.freeradbiomed.2010.05.035"}], "href": "https://doi.org/10.1016/j.freeradbiomed.2010.05.035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20542496"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20542496"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Yumie Takata, Alan R Kristal, Regina M Santella, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Selenium, selenoenzymes, oxidative stress and risk of neoplastic progression from Barrett's esophagus: results from biomarkers and genetic variants."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0038612"}], "href": "https://doi.org/10.1371/journal.pone.0038612"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22715394"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22715394"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Hellmuth A Meyer, Tobias Endermann, Carsten Stephan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Selenoprotein P status correlates to cancer-specific mortality in renal cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0046644"}], "href": "https://doi.org/10.1371/journal.pone.0046644"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23056383"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23056383"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Catherine Méplan, Lars Ove Dragsted, Gitte Ravn-Haren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between polymorphisms in glutathione peroxidase and selenoprotein P genes, glutathione peroxidase activity, HRT use and breast cancer risk."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0073316"}], "href": "https://doi.org/10.1371/journal.pone.0073316"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24039907"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24039907"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Andrew J Pellatt, Roger K Wolff, Esther M John, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SEPP1 influences breast cancer risk among women with greater native american ancestry: the breast cancer health disparities study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0080554"}], "href": "https://doi.org/10.1371/journal.pone.0080554"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24278290"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24278290"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Milan S Geybels, Piet A van den Brandt, Leo J Schouten, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Selenoprotein gene variants, toenail selenium levels, and risk for advanced prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Natl Cancer Inst (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jnci/dju003"}], "href": "https://doi.org/10.1093/jnci/dju003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24563517"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24563517"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "M Scharpf, U Schweizer, T Arzberger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuronal and ependymal expression of selenoprotein P in the human brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neural Transm (Vienna) (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00702-006-0617-0"}], "href": "https://doi.org/10.1007/s00702-006-0617-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17245539"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17245539"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Akihiro Higuchi, Kazuhiko Takahashi, Masaki Hirashima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Selenoprotein P controls oxidative stress in cornea."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0009911"}], "href": "https://doi.org/10.1371/journal.pone.0009911"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20360971"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20360971"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Andrea S Takemoto, Marla J Berry, Frederick P Bellinger "}, {"type": "b", "children": [{"type": "t", "text": "Role of selenoprotein P in Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ethn Dis (2010)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20521393"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20521393"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Frederick P Bellinger, Arjun V Raman, Rachel H Rueli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Changes in selenoprotein P in substantia nigra and putamen in Parkinson's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Parkinsons Dis (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/JPD-2012-11052"}], "href": "https://doi.org/10.3233/JPD-2012-11052"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23268326"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23268326"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Xiubo Du, Zhi Wang, Youbiao Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibitory effect of selenoprotein P on Cu(+)/Cu(2+)-induced Aβ42 aggregation and toxicity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Inorg Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/ic4028282"}], "href": "https://doi.org/10.1021/ic4028282"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24437729"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24437729"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Yukihito Kabuyama, Kengo Oshima, Takuya Kitamura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of selenoprotein P in the regulation of redox balance and myofibroblast viability in idiopathic pulmonary fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Cells (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2443.2007.01127.x"}], "href": "https://doi.org/10.1111/j.1365-2443.2007.01127.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17986007"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17986007"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Colleen Rock, Philip J Moos "}, {"type": "b", "children": [{"type": "t", "text": "Selenoprotein P regulation by the glucocorticoid receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biometals (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10534-009-9251-2"}], "href": "https://doi.org/10.1007/s10534-009-9251-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19513589"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19513589"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "X Forceville, V Mostert, A Pierantoni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Selenoprotein P, rather than glutathione peroxidase, as a potential marker of septic shock and related syndromes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Surg Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000239763"}], "href": "https://doi.org/10.1159/000239763"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19779296"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19779296"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "J Martitz, N-P Becker, K Renko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene-specific regulation of hepatic selenoprotein expression by interleukin-6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Metallomics (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1039/c5mt00211g"}], "href": "https://doi.org/10.1039/c5mt00211g"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26399395"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26399395"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Sarah P Short, Jennifer M Pilat, Caitlyn W Barrett, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Colonic Epithelial-Derived Selenoprotein P Is the Source for Antioxidant-Mediated Protection in Colitis-Associated Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2020.12.059"}], "href": "https://doi.org/10.1053/j.gastro.2020.12.059"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33388316"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33388316"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "B-J Ko, S M Kim, K H Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Levels of circulating selenoprotein P, fibroblast growth factor (FGF) 21 and FGF23 in relation to the metabolic syndrome in young children."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Obes (Lond) (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ijo.2014.45"}], "href": "https://doi.org/10.1038/ijo.2014.45"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24638201"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24638201"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Qin Wang, Li-Cui Sun, Yi-Qun Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Synergistic Effect of Serine with Selenocompounds on the Expression of SelP and GPx in HepG2 Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Trace Elem Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12011-016-0665-8"}], "href": "https://doi.org/10.1007/s12011-016-0665-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26944060"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26944060"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Sandra Hybsier, Torsten Schulz, Zida Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sex-specific and inter-individual differences in biomarkers of selenium status identified by a calibrated ELISA for selenoprotein P."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Redox Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.redox.2016.12.025"}], "href": "https://doi.org/10.1016/j.redox.2016.12.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28064116"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28064116"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Kamil Demircan, Ylva Bengtsson, Qian Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serum selenium, selenoprotein P and glutathione peroxidase 3 as predictors of mortality and recurrence following breast cancer diagnosis: A multicentre cohort study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Redox Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.redox.2021.102145"}], "href": "https://doi.org/10.1016/j.redox.2021.102145"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34563873"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34563873"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "Jinyuan Mao, Jessica J Vanderlelie, Anthony V Perkins, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic polymorphisms that affect selenium status and response to selenium supplementation in United Kingdom pregnant women."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Clin Nutr (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3945/ajcn.115.114231"}], "href": "https://doi.org/10.3945/ajcn.115.114231"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26675765"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26675765"}]}]}]}