SEMA4D Gene

HGNC Family	Immunoglobulin superfamily domain containing, CD molecules (CD), Semaphorins (SEMA)
Name	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
Description	Enables identical protein binding activity; semaphorin receptor binding activity; and transmembrane signaling receptor activity. Involved in several processes, including ossification involved in bone maturation; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and regulation of neuron projection development. Located in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSemaphorin 4D (Sema4D), originally characterized as an axon‐guidance molecule, has emerged as a multifaceted mediator in tumor biology, most notably by promoting angiogenesis and tumor progression. Binding with high affinity to plexin‐B1, Sema4D stimulates endothelial cell migration and neovascularization by triggering receptor tyrosine kinase cascades—including activation of Met, PI3K–Akt, MAPK, and RhoA pathways—which in turn promote invasive growth in various solid tumors such as head and neck, pancreatic, colorectal, and ovarian carcinomas. In several studies, overexpression of Sema4D correlated with enhanced tumor vascularity and poor prognosis, whereas its down‐modulation (for example, by microRNA‐mediated mechanisms) was associated with reduced tumor cell survival and vascular development."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its proangiogenic functions, Sema4D (also known as CD100) exerts important immunomodulatory roles. It is expressed on lymphocytes, B cells, and platelets, where it enhances cell survival and proliferation in certain hematological malignancies and modulates inflammatory responses. For example, studies in chronic lymphocytic leukemia have documented that Sema4D signaling reinforces pro‐survival pathways, while platelet‐derived Sema4D contributes to thrombus formation. Structural analyses have illuminated how Sema4D interacts with its receptors, and dysregulated expression of Sema4D has been implicated in autoimmune and inflammatory disorders such as systemic sclerosis, myeloid‐derived suppressor cell induction in the tumor microenvironment, MRONJ, psoriasis, and ankylosing spondylitis. Collectively, these findings underscore its potential as both a biomarker and a therapeutic target in immune‐mediated diseases."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in vascular and immune regulation, Sema4D also influences bone homeostasis. Osteoclast‐derived Sema4D inhibits osteoblast differentiation, thereby impairing bone formation and facilitating osteolytic lesions and skeletal metastases in cancers such as breast cancer and multiple myeloma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Paolo Conrotto, Donatella Valdembri, Simona Corso, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sema4D induces angiogenesis through Met recruitment by Plexin B1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2004-07-2885"}], "href": "https://doi.org/10.1182/blood-2004-07-2885"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15632204"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15632204"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "John R Basile, Talayeh Afkhami, J Silvio Gutkind "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.25.16.6889-6898.2005"}], "href": "https://doi.org/10.1128/MCB.25.16.6889-6898.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16055703"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16055703"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "John R Basile, Rogerio M Castilho, Vanessa P Williams, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin 4D provides a link between axon guidance processes and tumor-induced angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0508825103"}], "href": "https://doi.org/10.1073/pnas.0508825103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16754882"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16754882"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jakub M Swiercz, Thomas Worzfeld, Stefan Offermanns "}, {"type": "b", "children": [{"type": "t", "text": "ErbB-2 and met reciprocally regulate cellular signaling via plexin-B1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M706822200"}], "href": "https://doi.org/10.1074/jbc.M706822200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18025083"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18025083"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Shingo Kato, Kensuke Kubota, Takeshi Shimamura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin 4D, a lymphocyte semaphorin, enhances tumor cell motility through binding its receptor, plexinB1, in pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1349-7006.2011.02053.x"}], "href": "https://doi.org/10.1111/j.1349-7006.2011.02053.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21812859"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21812859"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "P N Gabrovska, R A Smith, T Tiang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Lycorine hydrochloride selectively inhibits human ovarian cancer cell proliferation and tumor neovascularization with very low toxicity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Toxicol Lett (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.toxlet.2013.01.018"}], "href": "https://doi.org/10.1016/j.toxlet.2013.01.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23376478"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23376478"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ying Chen, Lei Zhang, Rui Lv, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of Semaphorin4D indicates poor prognosis and prompts monocyte differentiation toward M2 macrophages in epithelial ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian Pac J Cancer Prev (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7314/apjcp.2013.14.10.5883"}], "href": "https://doi.org/10.7314/apjcp.2013.14.10.5883"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24289594"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24289594"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jin-Shen Wang, Chang-Qing Jing, Ke-Shu Shan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin 4D and hypoxia-inducible factor-1α overexpression is related to prognosis in colorectal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Gastroenterol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3748/wjg.v21.i7.2191"}], "href": "https://doi.org/10.3748/wjg.v21.i7.2191"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25717256"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25717256"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Ying Chen, Lei Zhang, Wen-Xin Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VEGF and SEMA4D have synergistic effects on the promotion of angiogenesis in epithelial ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol Lett (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s11658-017-0058-9"}], "href": "https://doi.org/10.1186/s11658-017-0058-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29308068"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29308068"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yang Liu, Honglin Zhou, Lan Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-214 suppressed ovarian cancer and negatively regulated semaphorin 4D."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-015-4708-0"}], "href": "https://doi.org/10.1007/s13277-015-4708-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26718213"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26718213"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Luisa Granziero, Paola Circosta, Cristina Scielzo, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "CD38 and CD100 lead a network of surface receptors relaying positive signals for B-CLL growth and survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2004-10-3873"}], "href": "https://doi.org/10.1182/blood-2004-10-3873"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15613544"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15613544"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Li Zhu, Wolfgang Bergmeier, Jie Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0606344104"}], "href": "https://doi.org/10.1073/pnas.0606344104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17244710"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17244710"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Bert J C Janssen, Ross A Robinson, Francesc Pérez-Brangulí, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Peripheral blood lymphocytes analysis detects CD100/SEMA4D alteration in systemic sclerosis patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autoimmunity (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/08916934.2010.541171"}], "href": "https://doi.org/10.3109/08916934.2010.541171"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21244334"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21244334"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Rania H Younis, Kyu Lee Han, Tonya J Webb "}, {"type": "b", "children": [{"type": "t", "text": "Human Head and Neck Squamous Cell Carcinoma-Associated Semaphorin 4D Induces Expansion of Myeloid-Derived Suppressor Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1501293"}], "href": "https://doi.org/10.4049/jimmunol.1501293"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26740106"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26740106"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Alexandru Movila, Hani Mawardi, Kazuaki Nishimura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Possible pathogenic engagement of soluble Semaphorin 4D produced by γδT cells in medication-related osteonecrosis of the jaw (MRONJ)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2016.10.012"}], "href": "https://doi.org/10.1016/j.bbrc.2016.10.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27720716"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27720716"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Chen Zhang, Chunying Xiao, Erle Dang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CD100-Plexin-B2 Promotes the Inflammation in Psoriasis by Activating NF-κB and the Inflammasome in Keratinocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jid.2017.09.005"}], "href": "https://doi.org/10.1016/j.jid.2017.09.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28927892"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28927892"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Misagh Rajabinejad, Gelayol Asadi, Sedigheh Ranjbar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin 4A, 4C, and 4D: Function comparison in the autoimmunity, allergy, and cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2020.144637"}], "href": "https://doi.org/10.1016/j.gene.2020.144637"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32244055"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32244055"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Jianmin Xie, Zitao Wang, Wen Wang "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin 4D Induces an Imbalance of Th17/Treg Cells by Activating the Aryl Hydrocarbon Receptor in Ankylosing Spondylitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2020.02151"}], "href": "https://doi.org/10.3389/fimmu.2020.02151"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33013906"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33013906"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Ying-Hua Yang, Asma Buhamrah, Abraham Schneider, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin 4D Promotes Skeletal Metastasis in Breast Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0150151"}], "href": "https://doi.org/10.1371/journal.pone.0150151"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26910109"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26910109"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Evangelos Terpos, Ioannis Ntanasis-Stathopoulos, Dimitrios Christoulas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin 4D correlates with increased bone resorption, hypercalcemia, and disease stage in newly diagnosed patients with multiple myeloma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood Cancer J (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41408-018-0075-6"}], "href": "https://doi.org/10.1038/s41408-018-0075-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29748532"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29748532"}]}]}]}
Synonyms	SEMAJ, COLL-4, CD100, M-SEMA-G, COLL4, C9ORF164
Proteins	SEM4D_HUMAN
NCBI Gene ID	10507
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SEMA4D has 7,373 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 127 datasets.

Click the + buttons to view associations for SEMA4D from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SEMA4D Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SEMA4D gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SEMA4D gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SEMA4D gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SEMA4D gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SEMA4D gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SEMA4D gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SEMA4D gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SEMA4D gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SEMA4D gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SEMA4D gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SEMA4D gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SEMA4D gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SEMA4D protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SEMA4D gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SEMA4D gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SEMA4D gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SEMA4D gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with SEMA4D gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SEMA4D gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SEMA4D protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SEMA4D protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing SEMA4D protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing SEMA4D protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SEMA4D protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SEMA4D protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SEMA4D gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with SEMA4D gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of SEMA4D protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SEMA4D gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with SEMA4D gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SEMA4D gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SEMA4D gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SEMA4D gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SEMA4D gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SEMA4D gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SEMA4D gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SEMA4D gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SEMA4D gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SEMA4D from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with SEMA4D gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.