{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSENCR is a vascular‐enriched long noncoding RNA that plays a critical role in endothelial biology. It is dynamically regulated during the commitment of human embryonic stem cells to the mesoderm and endothelial lineages, where its overexpression promotes early differentiation as well as enhances endothelial proliferation, migration, and angiogenesis. Moreover, SENCR helps maintain endothelial barrier integrity by physically interacting with cytoskeletal-associated proteins (e.g., CKAP4) to stabilize cell–cell adherens junctions in response to laminar shear stress."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nSENCR also exerts important regulatory functions in vascular smooth muscle cells (VSMCs). In human aortic-VSMCs, overexpression of SENCR suppresses proliferation and migration through modulation of the miR-4731-5p/FOXO3a pathway, and this regulatory effect is clinically relevant as SENCR levels in patient plasma correlate with the severity of coronary heart disease. In addition, SENCR overexpression protects endothelial cells from the anti-proliferative and anti-migratory effects of rapamycin by modulating ERK1/2 and mTOR signaling pathways, suggesting a therapeutic potential in the context of drug-eluting stents."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n\nEmerging evidence also implicates SENCR in other disease contexts, although its role remains to be fully defined. For instance, its function in aortic dissection is still under investigation, while increased SENCR expression has been observed in cisplatin-resistant lung cancer cells. Conversely, genetic analyses indicate that the SENCR rs555172 polymorphism is not associated with an increased risk for preeclampsia. These findings underscore the multifaceted roles of SENCR in vascular biology and disease, and highlight the need for further studies to elucidate its mechanisms in different pathological settings."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mounia Boulberdaa, Elizabeth Scott, Margaret Ballantyne, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Role for the Long Noncoding RNA SENCR in Commitment and Function of Endothelial Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Ther (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/mt.2016.41"}], "href": "https://doi.org/10.1038/mt.2016.41"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26898221"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26898221"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Qing Lyu, Suowen Xu, Yuyan Lyu, et al. "}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "SENCR"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " stabilizes vascular endothelial cell adherens junctions through interaction with CKAP4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1810729116"}], "href": "https://doi.org/10.1073/pnas.1810729116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30584103"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30584103"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Famin Ye, Jing Zhang, Qiaoling Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Preliminary study on the mechanism of long noncoding RNA SENCR regulating the proliferation and migration of vascular smooth muscle cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29775"}], "href": "https://doi.org/10.1002/jcp.29775"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32401347"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32401347"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hongtao Sun, Shuiyun Wang, Min Song "}, {"type": "b", "children": [{"type": "t", "text": "Long non‑coding RNA SENCR alleviates the inhibitory effects of rapamycin on human umbilical vein endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2018.9094"}], "href": "https://doi.org/10.3892/mmr.2018.9094"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29845247"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29845247"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yi Song, Tao Wang, Chunjie Mu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SENCR overexpression attenuated the proliferation, migration and phenotypic switching of vascular smooth muscle cells in aortic dissection via the miR-206/myocardin axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nutr Metab Cardiovasc Dis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.numecd.2022.03.004"}], "href": "https://doi.org/10.1016/j.numecd.2022.03.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35351345"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35351345"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Qiang Shen, Huixin Zhou, Meijuan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Super enhancer-LncRNA SENCR promoted cisplatin resistance and growth of NSCLC through upregulating FLI1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.24460"}], "href": "https://doi.org/10.1002/jcla.24460"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35500152"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35500152"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Mohsen Saravani, Mostafa Saeedinia, Majid Zaki-Dizaji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The relationship between preeclampsia risk and SENCR rs555172 gene polymorphism and expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol (Noisy-le-grand) (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14715/cmb/2024.70.3.11"}], "href": "https://doi.org/10.14715/cmb/2024.70.3.11"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38650152"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38650152"}]}]}]}