SENP7 Gene

Name	SUMO1/sentrin specific peptidase 7
Description	The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSENP7 is a SUMO-specific protease that has been shown to adopt unique structural features in its catalytic domain, which confer a marked preference for deconjugating SUMO2/3 from modified substrates. High-resolution crystallographic studies reveal that a distinct loop insertion and other specialized elements in SENP7 allow efficient processing of di- and poly-SUMO2/3 chains, and mutational analyses underscore the importance of these structural determinants for enzyme activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its core catalytic role, SENP7 participates in a range of cellular processes that impact both genome integrity and tumorigenesis. Differential splicing in mammary epithelia gives rise to distinct SENP7 isoforms, with evidence that the long variant (SENP7L) promotes gene expression programs linked to epithelial-to-mesenchymal transition, while the short variant (SENP7S) acts in a tumor-suppressive manner. In other contexts, SENP7 facilitates chromatin remodeling by interacting with chromatin repressors such as KAP1 via HP1α, thereby promoting the removal of SUMO2/3 from target proteins and creating a permissive environment for DNA repair. SENP7 also modulates post-translational modifications of oncogenic proteins, exemplified by its regulation of c-Myc SUMOylation, and its aberrant expression or degradation—mediated by factors like SPOP—has been linked to enhanced metastasis in hepatocellular carcinoma. Furthermore, upregulation of SENP7 in intestinal epithelial cells has been correlated with inflammatory bowel disease, underscoring its impact on tissue homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, SENP7 functions as an oxidative stress sensor in CD8+ T cells, where it modulates cellular metabolism by promoting deSUMOylation of PTEN. This process prevents PTEN-dependent metabolic defects and is critical for sustaining glycolysis, oxidative phosphorylation, and the overall antitumor effector function of these immune cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Christopher D Lima, David Reverter "}, {"type": "b", "children": [{"type": "t", "text": "Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M805655200"}], "href": "https://doi.org/10.1074/jbc.M805655200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18799455"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18799455"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kamela O Alegre, David Reverter "}, {"type": "b", "children": [{"type": "t", "text": "Swapping small ubiquitin-like modifier (SUMO) isoform specificity of SUMO proteases SENP6 and SENP7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.268847"}], "href": "https://doi.org/10.1074/jbc.M111.268847"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21878624"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21878624"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Tasneem Bawa-Khalfe, Long-Sheng Lu, Yong Zuo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential expression of SUMO-specific protease 7 variants regulates epithelial-mesenchymal transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1209378109"}], "href": "https://doi.org/10.1073/pnas.1209378109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23045645"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23045645"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Alexander J Garvin, Ruth M Densham, Sarah A Blair-Reid, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/embor.2013.141"}], "href": "https://doi.org/10.1038/embor.2013.141"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24018422"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24018422"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Román González-Prieto, Sabine Ag Cuijpers, Ramesh Kumar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2015.1040965"}], "href": "https://doi.org/10.1080/15384101.2015.1040965"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25895136"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25895136"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Samaneh Karami, Feng-Ming Lin, Santosh Kumar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel SUMO-Protease SENP7S Regulates β-catenin Signaling and Mammary Epithelial Cell Transformation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep46477"}], "href": "https://doi.org/10.1038/srep46477"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28429743"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28429743"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Piyou Ji, Shaohua Liang, Pengtao Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Speckle-type POZ protein suppresses hepatocellular carcinoma cell migration and invasion via ubiquitin-dependent proteolysis of SUMO1/sentrin specific peptidase 7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.05.115"}], "href": "https://doi.org/10.1016/j.bbrc.2018.05.115"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29777712"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29777712"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Aamir Suhail, Zaigham Abbas Rizvi, Prabhakar Mujagond, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DeSUMOylase SENP7-Mediated Epithelial Signaling Triggers Intestinal Inflammation via Expansion of Gamma-Delta T Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2019.11.028"}], "href": "https://doi.org/10.1016/j.celrep.2019.11.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31825833"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31825833"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Zhongqiu Wu, Haiyan Huang, Qiaoqiao Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SENP7 senses oxidative stress to sustain metabolic fitness and antitumor functions of CD8+ T cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI155224"}], "href": "https://doi.org/10.1172/JCI155224"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35143421"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35143421"}]}]}]}
Proteins	SENP7_HUMAN
NCBI Gene ID	57337
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SENP7 has 5,992 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 115 datasets.

Click the + buttons to view associations for SENP7 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SENP7 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SENP7 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SENP7 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SENP7 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SENP7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SENP7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SENP7 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SENP7 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SENP7 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SENP7 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SENP7 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SENP7 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SENP7 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SENP7 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SENP7 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SENP7 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SENP7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SENP7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of SENP7 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SENP7 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SENP7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing SENP7 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SENP7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SENP7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SENP7 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SENP7 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with SENP7 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of SENP7 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SENP7 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for SENP7 protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SENP7 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SENP7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SENP7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SENP7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SENP7 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SENP7 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SENP7 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SENP7 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of SENP7 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with SENP7 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing SENP7 from the GeneSigDB Published Gene Signatures dataset.