SEPT5-GP1BB Gene

Name	SEPT5-GP1BB readthrough
Description	This locus represents naturally occurring read-through transcription between the neighboring SEPT5 (septin 5) and GP1BB (glycoprotein Ib (platelet), beta polypeptide) genes on chromosome 22. This read-through transcription arises from inefficient use of an imperfect polyA signal in the upstream SEPT5 gene, whereby transcription continues into the GP1BB gene. Alternative splicing results in multiple read-through variants. The read-through transcripts are candidates for nonsense-mediated mRNA decay (NMD), and are therefore unlikely to produce protein products. [provided by RefSeq, Dec 2010]
Synonyms	GPIb-beta, GP1BB
NCBI Gene ID	100526833
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SEPT5-GP1BB has 1,123 functional associations with biological entities spanning 5 categories (molecular profile, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 16 datasets.

Click the + buttons to view associations for SEPT5-GP1BB from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SEPT5-GP1BB Gene

Functional Associations

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	Dataset	Summary
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SEPT5-GP1BB gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SEPT5-GP1BB gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SEPT5-GP1BB gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SEPT5-GP1BB gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SEPT5-GP1BB gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of SEPT5-GP1BB gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of SEPT5-GP1BB gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of SEPT5-GP1BB gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SEPT5-GP1BB gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
	JASPAR Predicted Transcription Factor Targets	transcription factors regulating expression of SEPT5-GP1BB gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	cell lines with high or low copy number of SEPT5-GP1BB gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	cell lines with high or low expression of SEPT5-GP1BB gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	transcription factor perturbations changing expression of SEPT5-GP1BB gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
	MotifMap Predicted Transcription Factor Targets	transcription factors regulating expression of SEPT5-GP1BB gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	cell types and tissues with high or low DNA methylation of SEPT5-GP1BB gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
	Roadmap Epigenomics Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SEPT5-GP1BB gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.