| Name | septin 1 |
| Description | This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis and the maintenance of cellular morphology. This gene encodes a protein that can form homo- and heterooligomeric filaments, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. Alternatively spliced transcript variants have been found but the full-length nature of these variants has not been determined. [provided by RefSeq, Dec 2012] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSEPTIN1 is a conserved GTPase that plays a critical role during cell division. In mitosis, it interacts with the serine/threonine kinase Aurora‐B, which phosphorylates SEPTIN1 at specific serine residues (Ser248, Ser307, and Ser315). This modification appears to modulate SEPTIN1’s functions during cytokinesis, where, despite previous notions of septins exclusively localizing to the cleavage furrow, SEPTIN1 is found at the spindle pole throughout mitosis—hinting at a potential role in both cytokinesis and chromosome segregation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "In studies involving human skin tissues and oral squamous-cell carcinoma, SEPTIN1 has been shown to associate with the actin cytoskeleton. It localizes prominently to lamellipodia—cellular protrusions essential for cell spreading and migration—where its enrichment depends on the integrity of the cortical actin framework. SEPTIN1 forms complexes with other septin family members, such as SEPT5, and its depletion impairs cell spreading. Moreover, its marked up-regulation in oral carcinoma relative to normal or premalignant tissues suggests that SEPTIN1 may contribute to cancer cell proliferation and progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "SEPTIN1 also plays an essential role in maintaining intracellular organelle architecture. A SEPTIN1‐based scaffold at the Golgi apparatus is crucial for proper Golgi ribbon organization. Here, SEPTIN1 collaborates with Golgi matrix proteins and centrosomal components to promote local microtubule nucleation and ensure the perinuclear positioning of Golgi membranes. Loss of SEPTIN1 results in marked Golgi fragmentation and subsequent impairment of anterograde membrane trafficking."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Meiyan Qi, Wenbo Yu, Shen Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Septin1, a new interaction partner for human serine/threonine kinase aurora-B."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2005.06.212"}], "href": "https://doi.org/10.1016/j.bbrc.2005.06.212"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16179162"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16179162"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yoshikuni Kato, Katsuhiro Uzawa, Nobuharu Yamamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of Septin1: possible contribution to the development of oral cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2007)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17912427"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17912427"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yoko Mizutani, Hidenori Ito, Ikuko Iwamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Possible role of a septin, SEPT1, in spreading in squamous cell carcinoma DJM-1 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1515/hsz-2012-0258"}], "href": "https://doi.org/10.1515/hsz-2012-0258"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23087102"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23087102"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kyungyeun Song, Claudia Gras, Gabrielle Capin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A SEPT1-based scaffold is required for Golgi integrity and function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.225557"}], "href": "https://doi.org/10.1242/jcs.225557"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30709970"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30709970"}]}]}]}
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| NCBI Gene ID | 1731 |
| API | |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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SEPTIN1 has 1,084 functional associations with biological entities spanning 6 categories (functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 33 datasets.
Click the + buttons to view associations for SEPTIN1 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of SEPTIN1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of SEPTIN1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of SEPTIN1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing SEPTIN1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with SEPTIN1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with SEPTIN1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with SEPTIN1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with SEPTIN1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with SEPTIN1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving SEPTIN1 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving SEPTIN1 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing SEPTIN1 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing SEPTIN1 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by SEPTIN1 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by SEPTIN1 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of SEPTIN1 gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of SEPTIN1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of SEPTIN1 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with SEPTIN1 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of SEPTIN1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of SEPTIN1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| KEGG Pathways 2026 | pathways involving SEPTIN1 protein from the KEGG Pathways 2026 dataset. | |
| MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of SEPTIN1 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of SEPTIN1 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving SEPTIN1 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of SEPTIN1 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of SEPTIN1 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of SEPTIN1 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of SEPTIN1 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Sci-Plex Drug Perturbation Signatures | drug perturbations changing expression of SEPTIN1 gene from the Sci-Plex Drug Perturbation Signatures dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of SEPTIN1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of SEPTIN1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with SEPTIN1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
