{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSEPTIN10 is a recently identified member of the septin family of cytoskeletal proteins that harbors a conserved GTP‐binding motif and displays intrinsic GTPase activity. Initially characterized in human dendritic cells, SEPTIN10 is ubiquitously expressed—with heightened levels in heart, kidney, placenta, skeletal muscle, liver, lung, and various tumor cell lines—and its expression increases upon LPS-induced maturation. In addition, its subcellular distribution, observed in both the cytoplasm and nucleus, suggests multifaceted roles in cellular regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its canonical role in the cytoskeleton, SEPTIN10 has been implicated in modulating microtubule dynamics. Overexpression studies indicate that increased SEPTIN10 levels enhance cellular sensitivity to paclitaxel—a frontline chemotherapeutic agent—by contributing to microtubule stabilization. Conversely, diminished SEPTIN10 expression correlates with paclitaxel resistance in tumor cells, pointing to its potential as a biomarker for chemotherapy responsiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of developmental biology, SEPTIN10 plays a regulatory role in retinal progenitor cell (RPC) fate determination. Modulation by miR-124-3p demonstrates that downregulation of SEPTIN10 leads to reduced RPC proliferation and enhanced differentiation toward neuronal and ganglion cell lineages, while its upregulation can rescue proliferative deficits. These findings highlight SEPTIN10 as a critical mediator in balancing proliferation and differentiation within RPCs, which is essential for developing effective cell-based therapies for retinal degenerative diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSEPTIN10 is also involved in environmental stress responses. Following exposure to fine particulate matter (PM2.5), exosomal delivery of circCLIP1 results in an upregulation of SEPTIN10 in recipient airway cells. This increase is associated with enhanced mucus secretion in bronchial epithelial cells and increased contractility of airway smooth muscle cells, thereby linking SEPTIN10 to the pathogenesis of PM2.5-induced airway obstruction."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, SEPTIN10 functions as a molecular switch in hepatocellular carcinoma by governing the crosstalk between actin filaments and microtubules. Through direct interactions with regulators such as CAPZA2 and MAP4, SEPTIN10 reinforces actin stress fiber formation while concurrently inhibiting microtubule polymerization. This dynamic balance not only sustains intracellular tension but also facilitates YAP/TAZ-dependent oncogenic signaling, thereby promoting cancer cell viability, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lili Sui, Weiping Zhang, Qiuyan Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cloning and functional characterization of human septin 10, a novel member of septin family cloned from dendritic cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0006-291x(03)00601-6"}], "href": "https://doi.org/10.1016/s0006-291x(03"}, {"type": "t", "text": "00601-6) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12711328"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12711328"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mingli Xu, Masakatsu Takanashi, Kosuke Oikawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a novel role of Septin 10 in paclitaxel-resistance in cancers through a functional genomics screen."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1349-7006.2012.02221.x"}], "href": "https://doi.org/10.1111/j.1349-7006.2012.02221.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22320903"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22320903"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Bingqiao Shen, Huiqin Gao, Dandan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-124-3p regulates the proliferation and differentiation of retinal progenitor cells through SEPT10."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Tissue Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00441-023-03750-0"}], "href": "https://doi.org/10.1007/s00441-023-03750-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36802303"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36802303"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Huanhuan Zhu, Xiying Tang, Huilin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal circCLIP1 regulates PM"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "2.5"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": "-induced airway obstruction via targeting SEPT10 in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ecotoxicol Environ Saf (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ecoenv.2023.114750"}], "href": "https://doi.org/10.1016/j.ecoenv.2023.114750"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36950992"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36950992"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Sofia M E Weiler, Michaela Bissinger, Fabian Rose, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SEPTIN10-mediated crosstalk between cytoskeletal networks controls mechanotransduction and oncogenic YAP/TAZ signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2024.216637"}], "href": "https://doi.org/10.1016/j.canlet.2024.216637"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38242197"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38242197"}]}]}]}