| HGNC Family | Serpin peptidase inhibitors (SERPIN) |
| Name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 |
| Description | There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.[provided by RefSeq, Jun 2012] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSERPINA7, located on the X‐chromosome, encodes thyroxine‑binding globulin (TBG), the principal transporter of thyroid hormones in human serum. Detailed analyses of its genomic organization have revealed that, despite belonging to the serpin family, its structure comprises five exons with characteristic cis‑regulatory elements (including TATA and CAAT boxes and a hepatocyte nuclear factor‑1 binding site) that ensure liver‑specific expression. These promoter regions have been further exploited in hepatic gene therapy to achieve persistent and high‑level expression of transgenes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nStructural and functional studies of TBG have demonstrated that its ability to bind and release thyroid hormones is tightly regulated by conformational changes. In particular, the transition from a “stressed” to a “relaxed” state—mediated by the insertion of the reactive center loop into β‑sheet A—leads to a decrease in thyroxine affinity. High‑resolution crystallographic investigations and targeted mutagenesis have pinpointed key allosteric interactions and residues critical for this process. Moreover, numerous mutations in SERPINA7—including splice site disruptions, missense substitutions, frameshift mutations, and compound hemizygous variants—have been identified as causes of inherited TBG deficiency. Such mutations may alter glycosylation sites or protein stability (as seen in variants like TBG‑Chicago with enhanced heat stability), thereby impacting thyroid hormone homeostasis despite normal free hormone and TSH levels."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "15"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its traditional role in thyroid hormone transport, alterations in TBG levels have emerged as potential biomarkers in other clinical settings. Elevated plasma TBG concentrations have been correlated with chronic obstructive pulmonary disease (COPD), where they are associated with impaired lung function and a higher risk of acute exacerbations. In parallel, investigations into partial TBG deficiency—utilizing approaches such as X‑chromosome inactivation analysis and mutant protein structural modeling—have expanded our understanding of the genetic and phenotypic diversity underlying thyroid hormone regulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "18"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Y Hayashi, Y Mori, O E Janssen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human thyroxine-binding globulin gene: complete sequence and transcriptional regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (1993)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/mend.7.8.8232304"}], "href": "https://doi.org/10.1210/mend.7.8.8232304"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "8232304"}], "href": "https://pubmed.ncbi.nlm.nih.gov/8232304"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Rita Domingues, Paula Font, Luís Sobrinho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel variant in Serpina7 gene in a family with thyroxine-binding globulin deficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrine (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12020-009-9202-2"}], "href": "https://doi.org/10.1007/s12020-009-9202-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19415532"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19415532"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zhonghai Yan, Hao Yan, Hailong Ou "}, {"type": "b", "children": [{"type": "t", "text": "Human thyroxine binding globulin (TBG) promoter directs efficient and sustaining transgene expression in liver-specific pattern."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2012.07.009"}], "href": "https://doi.org/10.1016/j.gene.2012.07.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22820390"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22820390"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sirimon Reutrakul, Alexandra Dumitrescu, Paolo E Macchia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Complete thyroxine-binding globulin (TBG) deficiency in two families without mutations in coding or promoter regions of the TBG genes: in vitro demonstration of exon skipping."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jcem.87.3.8275"}], "href": "https://doi.org/10.1210/jcem.87.3.8275"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11889160"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11889160"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Rita Domingues, Maria João Bugalho, António Garrão, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Two novel variants in the thyroxine-binding globulin (TBG) gene behind the diagnosis of TBG deficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Endocrinol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/eje.0.1460485"}], "href": "https://doi.org/10.1530/eje.0.1460485"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11916615"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11916615"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Helmut Grasberger, Henriette M B Golcher, Anja Fingerhut, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loop variants of the serpin thyroxine-binding globulin: implications for hormone release upon limited proteolysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20020014"}], "href": "https://doi.org/10.1042/BJ20020014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11931635"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11931635"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Katarzyna Lacka, Teresa Nizankowska, Agnieszka Ogrodowicz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel mutation (del 1711 G) in the TBG gene as a cause of complete TBG deficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thyroid (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/thy.2007.0023"}], "href": "https://doi.org/10.1089/thy.2007.0023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17887925"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17887925"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "U Duhan, P Patston "}, {"type": "b", "children": [{"type": "t", "text": "Explanation for the high heat stability of thyroxine binding globulin-Chicago."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocr Regul (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4149/endo_2010_02_43"}], "href": "https://doi.org/10.4149/endo_2010_02_43"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20429632"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20429632"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Xiaoqiang Qi, François Loiseau, Wee Lee Chan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.171082"}], "href": "https://doi.org/10.1074/jbc.M110.171082"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21325280"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21325280"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Ariel A Petruk, María S Labanda, Rosa M S Alvarez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The allosteric modulation of thyroxine-binding globulin affinity is entropy driven."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbagen.2013.02.023"}], "href": "https://doi.org/10.1016/j.bbagen.2013.02.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23458682"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23458682"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Alfonso Massimiliano Ferrara, Theodora Pappa, Jiao Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel mechanism of inherited TBG deficiency: mutation in a liver-specific enhancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2014-3490"}], "href": "https://doi.org/10.1210/jc.2014-3490"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25361180"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25361180"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "L-D Chen, H-J Lu, Y-L Gan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Partial thyroxine-binding globulin deficiency in a family with coding region mutations in the TBG gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Endocrinol Invest (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s40618-020-01245-1"}], "href": "https://doi.org/10.1007/s40618-020-01245-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32266677"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32266677"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yanlan Fang, Hong Chen, Qingqing Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Compound hemizygous variants in SERPINA7 gene cause thyroxine-binding globulin deficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Genomic Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mgg3.1571"}], "href": "https://doi.org/10.1002/mgg3.1571"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33554479"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33554479"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Lulu Cao, Xiaojia Lou, Lili Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The decrease of T3 / T4 is not hypothyroidism - a new mutation of Serpina7 gene results in partial thyroglobulin deficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmazie (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1691/ph.2021.1559"}], "href": "https://doi.org/10.1691/ph.2021.1559"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34481533"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34481533"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "S Gawandi, K Jothivel, S Kulkarni "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a novel mutation in thyroxine-binding globulin (TBG) gene associated with TBG-deficiency and its effect on the thyroid function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Endocrinol Invest (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s40618-021-01697-z"}], "href": "https://doi.org/10.1007/s40618-021-01697-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34761328"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34761328"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Wenqi Diao, Ning Shen, Yipeng Du, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of thyroxine-binding globulin as a candidate plasma marker of chronic obstructive pulmonary disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Chron Obstruct Pulmon Dis (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/COPD.S137806"}], "href": "https://doi.org/10.2147/COPD.S137806"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28579773"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28579773"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Cristiane Jeyce Gomes-Lima, Andressa Aby Faraj Linhares Maciel, Matheus de Oliveira Andrade, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thyroxine-binding globulin deficiency due to a novel SERPINA7 mutation: Clinical characterization, analysis of X-chromosome inactivation pattern and protein structural modeling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2018.05.018"}], "href": "https://doi.org/10.1016/j.gene.2018.05.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29733970"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29733970"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Jung Heo, Sang-Mi Kim, Hyun Jin Ryu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Mutations in the Thyroxine-Binding Globulin (TBG) Gene in Patients with TBG Deficiency in Korea."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinol Metab (Seoul) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3803/EnM.2022.1591"}], "href": "https://doi.org/10.3803/EnM.2022.1591"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36475360"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36475360"}]}]}]}
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| Synonyms | TBG, TBGQTL |
| Proteins | THBG_HUMAN |
| NCBI Gene ID | 6906 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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SERPINA7 has 3,492 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 87 datasets.
Click the + buttons to view associations for SERPINA7 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of SERPINA7 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of SERPINA7 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of SERPINA7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of SERPINA7 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of SERPINA7 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of SERPINA7 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of SERPINA7 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of SERPINA7 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of SERPINA7 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of SERPINA7 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of SERPINA7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of SERPINA7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| ClinVar Gene-Phenotype Associations 2025 | phenotypes associated with SERPINA7 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of SERPINA7 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing SERPINA7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing SERPINA7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with SERPINA7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with SERPINA7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of SERPINA7 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with SERPINA7 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Chemical Interactions | chemicals interacting with SERPINA7 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
| CTD Gene-Disease Associations | diseases associated with SERPINA7 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by SERPINA7 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with SERPINA7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with SERPINA7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with SERPINA7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with SERPINA7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| DrugBank Drug Targets | interacting drugs for SERPINA7 protein from the curated DrugBank Drug Targets dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at SERPINA7 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of SERPINA7 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of SERPINA7 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of SERPINA7 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with SERPINA7 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing SERPINA7 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of SERPINA7 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of SERPINA7 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of SERPINA7 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of SERPINA7 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of SERPINA7 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GlyGen Glycosylated Proteins | ligands (chemical) binding SERPINA7 protein from the GlyGen Glycosylated Proteins dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving SERPINA7 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving SERPINA7 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving SERPINA7 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing SERPINA7 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by SERPINA7 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by SERPINA7 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by SERPINA7 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of SERPINA7 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of SERPINA7 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with SERPINA7 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with SERPINA7 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with SERPINA7 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of SERPINA7 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HMDB Metabolites of Enzymes | interacting metabolites for SERPINA7 protein from the curated HMDB Metabolites of Enzymes dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of SERPINA7 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of SERPINA7 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPO Gene-Disease Associations | phenotypes associated with SERPINA7 gene by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset. | |
| HuBMAP Azimuth Cell Type Annotations | cell types associated with SERPINA7 gene from the HuBMAP Azimuth Cell Type Annotations dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for SERPINA7 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of SERPINA7 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of SERPINA7 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of SERPINA7 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways 2026 | pathways involving SERPINA7 protein from the KEGG Pathways 2026 dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of SERPINA7 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of SERPINA7 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of SERPINA7 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of SERPINA7 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
| LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of SERPINA7 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| LOCATE Curated Protein Localization Annotations | cellular components containing SERPINA7 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain SERPINA7 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of SERPINA7 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of SERPINA7 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for SERPINA7 from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of SERPINA7 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of SERPINA7 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving SERPINA7 protein from the Wikipathways PFOCR 2024 dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at SERPINA7 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of SERPINA7 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of SERPINA7 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of SERPINA7 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of SERPINA7 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of SERPINA7 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of SERPINA7 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of SERPINA7 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of SERPINA7 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with SERPINA7 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with SERPINA7 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
