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Mutations or altered expression of SERPINH1 lead to dramatic effects on collagen synthesis, contributing to diseases such as osteogenesis imperfecta and preterm premature rupture of membranes, while natural polymorphisms in its promoter affect its expression among different populations."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn fibrotic diseases and wound‐healing contexts, SERPINH1 expression is robustly induced by profibrotic cytokines such as TGF‑β and IL‑1β, leading to enhanced collagen synthesis and deposition. Elevated HSP47 levels correlate with increased extracellular matrix production in liver fibrosis, intestinal fibrosis in Crohn’s disease, Dupuytren’s contracture, and chronic rhinosinusitis. 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