SFRP1 Gene

HGNC Family	Secreted frizzled-related proteins (SFRP)
Name	secreted frizzled-related protein 1
Description	This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSecreted frizzled‐related protein 1 (SFRP1) is a secreted glycoprotein that exerts its primary function as a negative regulator of the canonical Wnt/β–catenin signaling pathway. Its modular structure—featuring an amino‐terminal cysteine‑rich domain (CRD) homologous to Frizzled receptors and a carboxy‑terminal netrin‑like domain—underpins its ability to bind and sequester Wnt ligands, thereby modulating downstream signals that govern cell proliferation, differentiation, and apoptosis. This structural basis is critical not only for its normal developmental roles—for example in osteoblast differentiation—but also for its tumor‑suppressive functions in several tissues."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn many human malignancies—including breast, renal, bladder, cervical, and hematological cancers—the downregulation of SFRP1 via promoter hypermethylation or related epigenetic modifications results in aberrant activation of Wnt signaling. Loss of SFRP1 expression thereby removes a key brake on oncogenic pathways, contributing to increased cell proliferation, migration and ultimately, a more aggressive tumor phenotype. Notably, this epigenetic silencing has been documented as a poor prognostic indicator in several cancer types, and tissue‑specific patterns (for instance, a contrasting demethylation observed in oral squamous cell carcinoma) underscore the complex role of SFRP1 in tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond cancer, SFRP1 participates in the regulation of diverse physiological and pathophysiological processes. In ocular tissues, for instance, elevated expression of SFRP1 in the trabecular meshwork has been implicated in increased intraocular pressure associated with glaucoma. In addition, SFRP1 modulates mesenchymal differentiation and cellular viability in bone, contributing to osteoblast and osteocyte survival, while its regulation by hedgehog signaling pathways and in fibro‐inflammatory conditions—such as systemic sclerosis—illustrates its broader involvement in maintaining tissue homeostasis. Moreover, aberrant SFRP1 expression in specific tumor stroma (e.g., prostatic tissue) and its interplay with other signaling cascades serve not only as important biomarkers but also as potential therapeutic targets."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jae Min Chong, Aykut Uren, Jeffrey S Rubin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disulfide bond assignments of secreted Frizzled-related protein-1 provide insights about Frizzled homology and netrin modules."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M108533200"}], "href": "https://doi.org/10.1074/jbc.M108533200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11741940"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11741940"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Takayuki Fukui, Masashi Kondo, Genshi Ito, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional silencing of secreted frizzled related protein 1 (SFRP 1) by promoter hypermethylation in non-small-cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1208777"}], "href": "https://doi.org/10.1038/sj.onc.1208777"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16007200"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16007200"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Peter V N Bodine, Julia Billiard, Robert A Moran, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.20599"}], "href": "https://doi.org/10.1002/jcb.20599"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16149051"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16149051"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yuriko Katoh, Masaru Katoh "}, {"type": "b", "children": [{"type": "t", "text": "WNT antagonist, SFRP1, is Hedgehog signaling target."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2006)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16328026"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16328026"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "K R Hughes, F Sablitzky, Y R Mahida "}, {"type": "b", "children": [{"type": "t", "text": "Expression profiling of Wnt family of genes in normal and inflammatory bowel disease primary human intestinal myofibroblasts and normal human colonic crypt epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Inflamm Bowel Dis (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ibd.21353"}], "href": "https://doi.org/10.1002/ibd.21353"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20848536"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20848536"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Te-Hui Liu, Aparna Raval, Shih-Shih Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CpG island methylation and expression of the secreted frizzled-related protein gene family in chronic lymphocytic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-05-3712"}], "href": "https://doi.org/10.1158/0008-5472.CAN-05-3712"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16423993"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16423993"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "J Veeck, D Niederacher, H An, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aberrant methylation of the Wnt antagonist SFRP1 in breast cancer is associated with unfavourable prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1209386"}], "href": "https://doi.org/10.1038/sj.onc.1209386"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16449975"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16449975"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Shinji Urakami, Hiroaki Shiina, Hideki Enokida, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Frequent loss of SFRP1 expression in multiple human solid tumours: association with aberrant promoter methylation in renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1210345"}], "href": "https://doi.org/10.1038/sj.onc.1210345"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17353908"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17353908"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Michelle L Gumz, Hongzhi Zou, Pamela A Kreinest, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-07-0143"}], "href": "https://doi.org/10.1158/1078-0432.CCR-07-0143"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17699851"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17699851"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Ming-Tzeung Chung, Hung-Cheng Lai, Huey-Kang Sytwu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SFRP1 and SFRP2 suppress the transformation and invasion abilities of cervical cancer cells through Wnt signal pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gynecol Oncol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygyno.2008.10.026"}], "href": "https://doi.org/10.1016/j.ygyno.2008.10.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19095296"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19095296"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Yutaka Matsuda, Thomas Schlange, Edward J Oakeley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WNT signaling enhances breast cancer cell motility and blockade of the WNT pathway by sFRP1 suppresses MDA-MB-231 xenograft growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/bcr2317"}], "href": "https://doi.org/10.1186/bcr2317"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19473496"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19473496"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Jie Hu, Aiwen Dong, Veronica Fernandez-Ruiz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Blockade of Wnt signaling inhibits angiogenesis and tumor growth in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-09-0541"}], "href": "https://doi.org/10.1158/0008-5472.CAN-09-0541"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19690140"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19690140"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "G Pannone, P Bufo, A Santoro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WNT pathway in oral cancer: epigenetic inactivation of WNT-inhibitors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2010.1035"}], "href": "https://doi.org/10.3892/or.2010.1035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20811686"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20811686"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Barbara Kinga Barták, Alexandra Kalmár, Bálint Péterfia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Colorectal adenoma and cancer detection based on altered methylation pattern of SFRP1, SFRP2, SDC2, and PRIMA1 in plasma samples."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epigenetics (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15592294.2017.1356957"}], "href": "https://doi.org/10.1080/15592294.2017.1356957"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28753106"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28753106"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jing He, Tao Sheng, Arwen A Stelter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Suppressing Wnt signaling by the hedgehog pathway through sFRP-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C600200200"}], "href": "https://doi.org/10.1074/jbc.C600200200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17035233"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17035233"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Wan-Heng Wang, Loretta G McNatt, Iok-Hou Pang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased expression of the WNT antagonist sFRP-1 in glaucoma elevates intraocular pressure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI33871"}], "href": "https://doi.org/10.1172/JCI33871"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18274669"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18274669"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "J C H Leijten, J Emons, C Sticht, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gremlin 1, frizzled-related protein, and Dkk-1 are key regulators of human articular cartilage homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Rheum (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/art.34535"}], "href": "https://doi.org/10.1002/art.34535"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22576962"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22576962"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Clara Dees, Inga Schlottmann, Robin Funke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Wnt antagonists DKK1 and SFRP1 are downregulated by promoter hypermethylation in systemic sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Rheum Dis (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/annrheumdis-2012-203194"}], "href": "https://doi.org/10.1136/annrheumdis-2012-203194"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23698475"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23698475"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Felix Sahm, Juliane Bissel, Christian Koelsche, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AKT1E17K mutations cluster with meningothelial and transitional meningiomas and can be detected by SFRP1 immunohistochemistry."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Neuropathol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00401-013-1187-5"}], "href": "https://doi.org/10.1007/s00401-013-1187-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24096618"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24096618"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Christopher J Ricketts, Victoria K Hill, W Marston Linehan "}, {"type": "b", "children": [{"type": "t", "text": "Tumor-specific hypermethylation of epigenetic biomarkers, including SFRP1, predicts for poorer survival in patients from the TCGA Kidney Renal Clear Cell Carcinoma (KIRC) project."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0085621"}], "href": "https://doi.org/10.1371/journal.pone.0085621"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24454902"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24454902"}]}]}]}
Synonyms	FRP-1, FRZA, SARP2
Proteins	SFRP1_HUMAN
NCBI Gene ID	6422
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SFRP1 has 15,677 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 119 datasets.

Click the + buttons to view associations for SFRP1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SFRP1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SFRP1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SFRP1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SFRP1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SFRP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SFRP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SFRP1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SFRP1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SFRP1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SFRP1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SFRP1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SFRP1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SFRP1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SFRP1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SFRP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SFRP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SFRP1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SFRP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SFRP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SFRP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SFRP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SFRP1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SFRP1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SFRP1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SFRP1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SFRP1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SFRP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SFRP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SFRP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SFRP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SFRP1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SFRP1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SFRP1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SFRP1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with SFRP1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with SFRP1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of SFRP1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with SFRP1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing SFRP1 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of SFRP1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of SFRP1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.