{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSFTA1P is a pseudogene‐derived long non‐coding RNA that has recently emerged as an important regulator in human cancers. In non‐small cell lung cancer, studies have shown that SFTA1P expression is significantly reduced in tumor tissues compared with normal tissues. This downregulation correlates with poor survival outcomes, and forced overexpression of SFTA1P was found to induce S‐phase cell cycle arrest and inhibit the PI3K–AKT signaling pathway, suggesting a tumor‐suppressor role in lung adenocarcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, in gastric cancer SFTA1P is markedly downregulated relative to adjacent normal tissues, and its decreased expression is associated with advanced tumor stage, larger tumor size, lymphatic metastasis, and poorer prognosis. Functional studies demonstrated that reintroducing SFTA1P inhibits cell proliferation, migration, and invasion, potentially via the modulation of TP53 expression. These findings further corroborate the notion that SFTA1P may act as a tumor suppressor in certain cancer contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nInterestingly, the role of SFTA1P appears to be context‐dependent. In cervical cancer, SFTA1P is found to be upregulated in tumor tissues, and high expression levels correlate with worse clinical outcomes. Mechanistic investigations revealed that SFTA1P interacts with the polypyrimidine tract binding protein 1 (PTBP1) to promote the degradation of tropomyosin 4 (TPM4) mRNA, thereby enhancing cell proliferation, migration, invasion, and metastasis. This oncogenic activity in cervical cancer highlights the complex, tissue‐specific functions of SFTA1P and suggests that targeting the SFTA1P–PTBP1–TPM4 axis could represent a novel therapeutic strategy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hua Zhang, Yaqiong Xiong, Rui Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The pseudogene-derived long noncoding RNA SFTA1P is down-regulated and suppresses cell migration and invasion in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1010428317691418"}], "href": "https://doi.org/10.1177/1010428317691418"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28231733"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28231733"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Dandan Du, Xian Shen, Yanqiu Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of long non-coding RNA SFTA1P and its function in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2020.153049"}], "href": "https://doi.org/10.1016/j.prp.2020.153049"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32825934"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32825934"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hongwei Ma, Tianshi Ma, Miao Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The pseudogene-derived long non-coding RNA SFTA1P suppresses cell proliferation, migration, and invasion in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20171193"}], "href": "https://doi.org/10.1042/BSR20171193"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29523596"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29523596"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Aoran Luo, Xiaoxiao Lan, Qiongzi Qiu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SFTA1P promotes cervical cancer progression by interaction with PTBP1 to facilitate TPM4 mRNA degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-022-05359-7"}], "href": "https://doi.org/10.1038/s41419-022-05359-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36344495"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36344495"}]}]}]}