{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSGK3 is an AGC family serine/threonine protein kinase that functions downstream of phosphoinositide 3‐kinase (PI3K) pathways. Uniquely, SGK3 contains a Phox homology (PX) domain that targets it to endosomes, where its activation is governed by dual phosphorylation events mediated by PDK1 and other kinases. Its endosomal localization is critically dependent on PI3K signaling—including both Class I and Class III (Vps34) pathways—and is further regulated by chaperone complexes such as Hsp90–Cdc37 that control its stability and activation. Innovative approaches using peroxisomal targeting have also provided insights into its protein–protein interactions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn cancer settings, SGK3 plays an oncogenic role that can be independent of Akt. In breast cancer, for example, oncogenic PIK3CA mutations and INPP4B upregulation drive SGK3 activation, thereby promoting estrogen receptor–mediated cell survival, 3D proliferation, invasive migration, and tumorigenesis. SGK3 is also implicated in melanoma, where it functions downstream of PDK1 to phosphorylate targets involved in metastasis, and its dysregulation in hepatocellular carcinoma and prostate cancer correlates with increased cell growth, poor patient prognosis, and enhanced androgen receptor–dependent proliferation. Beyond its roles in tumor biology, SGK3 regulates the activity and surface expression of multiple ion channels and transporters—including KCNE1/KCNQ1, ENaC, the inward hERG potassium channel, the neutral amino acid transporter SLC6A19, the creatine transporter SLC6A8, and even neuronal receptors such as GluR1—and thereby modulates membrane excitability and cellular ion homeostasis. Notably, in several settings SGK3 acts distinct from other SGK family members, and in cardiac cells it is not required for insulin‐dependent activation of PFK‐2."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "28"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond oncogenesis and ion transport regulation, SGK3 is emerging as a modulator of diverse physiological processes. It contributes to the control of cellular excitability by regulating inward rectifier potassium channels and acts additively with accessory proteins—such as stargazin—to enhance neurotransmitter receptor (e.g., GluR1) function. In endocrine tissues, SGK3 influences transporter activities and may modulate granulosa cell proliferation, with implications in conditions like polycystic ovary syndrome. Together, these findings underscore a multifaceted role for SGK3 in linking PI3K-derived lipid signals to key cellular processes including survival, proliferation, and membrane transport."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "29"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Maude Tessier, James R Woodgett "}, {"type": "b", "children": [{"type": "t", "text": "Role of the Phox homology domain and phosphorylation in activation of serum and glucocorticoid-regulated kinase-3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M604333200"}], "href": "https://doi.org/10.1074/jbc.M604333200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16790420"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16790420"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Benoit Bilanges, Bart Vanhaesebroeck "}, {"type": "b", "children": [{"type": "t", "text": "Cinderella finds her shoe: the first Vps34 inhibitor uncovers a new PI3K-AGC protein kinase connection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20141218"}], "href": "https://doi.org/10.1042/BJ20141218"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25395352"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25395352"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yuanzhong Wang, Wanping Xu, Dujin Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Coordinated regulation of serum- and glucocorticoid-inducible kinase 3 by a C-terminal hydrophobic motif and Hsp90-Cdc37 chaperone complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.518480"}], "href": "https://doi.org/10.1074/jbc.M113.518480"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24379398"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24379398"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Trine Nilsen, Thomas Slagsvold, Camilla Skiple Skjerpen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Peroxisomal targeting as a tool for assaying potein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M309653200"}], "href": "https://doi.org/10.1074/jbc.M309653200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14604990"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14604990"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jessica A Gasser, Hiroyuki Inuzuka, Alan W Lau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2014.09.023"}], "href": "https://doi.org/10.1016/j.molcel.2014.09.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25458846"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25458846"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ruzica Bago, Eeva Sommer, Pau Castel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embj.201693929"}], "href": "https://doi.org/10.15252/embj.201693929"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27481935"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27481935"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yuanzhong Wang, Dujin Zhou, Sheryl Phung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SGK3 is an estrogen-inducible kinase promoting estrogen-mediated survival of breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2010-0294"}], "href": "https://doi.org/10.1210/me.2010-0294"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21084382"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21084382"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hamdy M Embark, Christoph Böhmer, Volker Vallon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pflugers Arch (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00424-002-0982-y"}], "href": "https://doi.org/10.1007/s00424-002-0982-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12634932"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12634932"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "B Friedrich, Y Feng, P Cohen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pflugers Arch (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00424-002-0993-8"}], "href": "https://doi.org/10.1007/s00424-002-0993-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12632189"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12632189"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "N Gamper, S Fillon, Y Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pflugers Arch (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00424-002-0873-2"}], "href": "https://doi.org/10.1007/s00424-002-0873-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12397388"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12397388"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Thomas Slagsvold, Adriano Marchese, Andreas Brech, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CISK attenuates degradation of the chemokine receptor CXCR4 via the ubiquitin ligase AIP4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7601267"}], "href": "https://doi.org/10.1038/sj.emboj.7601267"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16888620"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16888620"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Guido Henke, Iwan Setiawan, Christoph Böhmer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of Na+/K+-ATPase by the serum and glucocorticoid-dependent kinase isoforms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kidney Blood Press Res (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000068699"}], "href": "https://doi.org/10.1159/000068699"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12590200"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12590200"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Christoph Böhmer, Mentor Sopjani, Fabian Klaus, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The serum and glucocorticoid inducible kinases SGK1-3 stimulate the neutral amino acid transporter SLC6A19."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000315092"}], "href": "https://doi.org/10.1159/000315092"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20511718"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20511718"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Manzar Shojaiefard, David L Christie, Florian Lang "}, {"type": "b", "children": [{"type": "t", "text": "Stimulation of the creatine transporter SLC6A8 by the protein kinases SGK1 and SGK3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2005.06.164"}], "href": "https://doi.org/10.1016/j.bbrc.2005.06.164"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16036218"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16036218"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Shawn M Lamothe, Shetuan Zhang "}, {"type": "b", "children": [{"type": "t", "text": "The serum- and glucocorticoid-inducible kinases SGK1 and SGK3 regulate hERG channel expression via ubiquitin ligase Nedd4-2 and GTPase Rab11."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.453670"}], "href": "https://doi.org/10.1074/jbc.M113.453670"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23589291"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23589291"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Marzia Scortegagna, Eric Lau, Tongwu Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PDK1 and SGK3 Contribute to the Growth of BRAF-Mutant Melanomas and Are Potential Therapeutic Targets."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-14-2785"}], "href": "https://doi.org/10.1158/0008-5472.CAN-14-2785"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25712345"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25712345"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Lihua Yao, Mingyang Li, Jingwen Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiRNA-335-5p negatively regulates granulosa cell proliferation via SGK3 in PCOS."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reproduction (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/REP-18-0229"}], "href": "https://doi.org/10.1530/REP-18-0229"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30328340"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30328340"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Meng Na Chi, Su Tang Guo, James S Wilmott, et al. "}, {"type": "b", "children": [{"type": "t", "text": "INPP4B is upregulated and functions as an oncogenic driver through SGK3 in a subset of melanomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.5359"}], "href": "https://doi.org/10.18632/oncotarget.5359"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26573229"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26573229"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Ming Liu, Leilei Chen, Tim Hon Man Chan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serum and glucocorticoid kinase 3 at 8q13.1 promotes cell proliferation and survival in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.25584"}], "href": "https://doi.org/10.1002/hep.25584"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22262416"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22262416"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Manya Wu, Chaoyuan Huang, Xinping Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-144-3p suppresses tumor growth and angiogenesis by targeting SGK3 in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2017.5900"}], "href": "https://doi.org/10.3892/or.2017.5900"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28849156"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28849156"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Gottlieb Maier, Monica Palmada, Jeyaganesh Rajamanickam, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of HERG channels by the serum and glucocorticoid inducible kinase isoform SGK3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000097666"}], "href": "https://doi.org/10.1159/000097666"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17167223"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17167223"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Yuanzhong Wang, Dujin Zhou, Shiuan Chen "}, {"type": "b", "children": [{"type": "t", "text": "SGK3 is an androgen-inducible kinase promoting prostate cancer cell proliferation through activation of p70 S6 kinase and up-regulation of cyclin D1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2013-1339"}], "href": "https://doi.org/10.1210/me.2013-1339"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24739041"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24739041"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Jun Xu, Ma Wan, Quanyuan He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SGK3 is associated with estrogen receptor expression in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res Treat (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10549-012-2081-x"}], "href": "https://doi.org/10.1007/s10549-012-2081-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22576469"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22576469"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Jun Xu, Lan Liao, Jun Qin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Flightless-I as a substrate of the cytokine-independent survival kinase CISK."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M807770200"}], "href": "https://doi.org/10.1074/jbc.M807770200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19293151"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19293151"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Geetha Nalairndran, Azad Hassan Abdul Razack, Chun-Wai Mai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphoinositide-dependent Kinase-1 (PDPK1) regulates serum/glucocorticoid-regulated Kinase 3 (SGK3) for prostate cancer cell survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.15876"}], "href": "https://doi.org/10.1111/jcmm.15876"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32926495"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32926495"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Carlos Munoz, Tatsiana Pakladok, Ahmad Almilaji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Up-regulation of Kir2.1 (KCNJ2) by the serum & glucocorticoid inducible SGK3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000358629"}], "href": "https://doi.org/10.1159/000358629"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24556932"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24556932"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Hui Cao, Zhong Xu, Jingxiao Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional role of SGK3 in PI3K/Pten driven liver tumor development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-019-5551-2"}], "href": "https://doi.org/10.1186/s12885-019-5551-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30975125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30975125"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Christoph Boehmer, Jeyaganesh Rajamanickam, Roman Schniepp, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of the excitatory amino acid transporter EAAT5 by the serum and glucocorticoid dependent kinases SGK1 and SGK3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2005.02.035"}], "href": "https://doi.org/10.1016/j.bbrc.2005.02.035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15737648"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15737648"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Nathalie Strutz-Seebohm, Guiscard Seebohm, Ganna Korniychuk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Additive regulation of GluR1 by stargazin and serum- and glucocorticoid-inducible kinase isoform SGK3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pflugers Arch (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00424-005-0032-7"}], "href": "https://doi.org/10.1007/s00424-005-0032-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16485113"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16485113"}]}]}]}