{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that long noncoding RNAs (lncRNAs) can play critical roles in cancer biology, and SGO1‐AS1 has emerged as a novel lncRNA associated with gastric carcinoma. In particular, evidence suggests that SGO1‐AS1 is involved in regulating key cellular processes that contribute to tumor progression, including cell proliferation, apoptosis, and metastasis. These findings highlight SGO1‐AS1 as a potential modulator of malignant transformation in gastric cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistic insights indicate that SGO1‐AS1 may influence gastric carcinoma progression by interacting with regulatory proteins and altering gene expression patterns critical for cancer cell survival and invasiveness. Such interactions could modulate various oncogenic signaling pathways, thereby affecting the tumor microenvironment and the evolution of the cancer phenotype."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, the clinical relevance of SGO1‐AS1 is underscored by its association with disease progression and patient prognosis. Its expression levels might serve as an informative biomarker for identifying aggressive gastric carcinoma and could represent a promising target for future therapeutic strategies. Overall, characterizing the function of SGO1‐AS1 provides valuable insights into the molecular underpinnings of gastric cancer and opens new avenues for intervention."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Donglan Huang, Ke Zhang, Wenying Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA SGO1-AS1 inactivates TGFβ signaling by facilitating TGFB1/2 mRNA decay and inhibits gastric carcinoma metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-021-02140-0"}], "href": "https://doi.org/10.1186/s13046-021-02140-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34706749"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34706749"}]}]}]}