{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSH2B3 (also known as LNK) has emerged as an important adaptor protein in cardiovascular regulation. Genome‐wide association studies have identified variants in SH2B3 that are significantly associated with both systolic and diastolic blood pressure, hypertension, and retinal vascular caliber, thereby implicating it in vascular remodeling and inflammatory responses underlying coronary heart disease and hypothyroidism. These findings suggest that altered SH2B3 expression or function may contribute to dysregulated cytokine signaling in vascular and hematopoietic cells, ultimately affecting blood vessel homeostasis and cardiovascular risk."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the arena of immune regulation and autoimmunity, SH2B3 plays a multifaceted role. Genetic studies in celiac disease, systemic lupus erythematosus, and other autoimmune conditions—such as multiple sclerosis, type 1 diabetes, and autoimmune hepatitis—have repeatedly implicated pathogenic variants of SH2B3. In some instances, the risk allele (for example, the nonsynonymous rs3184504 variant) is associated with enhanced activation of immune pathways (e.g. the NOD2 pathway), suggesting a role in modulating inflammatory responses. Collectively, these studies support a model where SH2B3 contributes to immune homeostasis and that dysregulation of its function predisposes individuals to autoimmunity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn hematopoietic disorders and leukemogenesis, SH2B3 functions as a critical negative regulator of cytokine‐induced JAK–STAT signaling. In myeloproliferative neoplasms and acute lymphoblastic leukemia, loss‐of‐function mutations or deletions of SH2B3 have been documented and are associated with increased and sustained growth factor signaling. In particular, studies in both blast‐phase myeloproliferative neoplasms and high‐risk B-cell precursor acute lymphoblastic leukemia reveal that compromised SH2B3 tumor suppressor activity accelerates leukemogenesis, underscoring its essential role in controlling lymphoid progenitor proliferation and transformation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "20", "end_ref": "28"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSH2B3 also modulates diverse cell signaling pathways beyond classical hematopoiesis. In endothelial cells, it regulates responses to proinflammatory stimuli by modulating PI3K–Akt and MAPK pathways, influencing focal adhesion dynamics and cell migration. In the nervous system, overexpression of SH2B3 has been found to inhibit neurotrophin-induced differentiation and neurite outgrowth, while in melanoma, elevated SH2B3 levels alter interferon signaling to promote cell survival. Moreover, an association of a haplotype spanning ATXN2 and SH2B3 with amyotrophic lateral sclerosis and differential histone acetylation at the SH2B3 promoter in placenta (correlating with reduced allergic sensitization) underscore its emerging roles in neurobiology, cancer, and immunomodulation. These observations collectively highlight the pleiotropic functions of SH2B3 in controlling cytokine receptor signaling and cellular homeostasis in multiple tissues."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "29", "end_ref": "36"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Daniel Levy, Georg B Ehret, Kenneth Rice, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study of blood pressure and hypertension."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.384"}], "href": "https://doi.org/10.1038/ng.384"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19430479"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19430479"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Christopher Newton-Cheh, Toby Johnson, Vesela Gateva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study identifies eight loci associated with blood pressure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.361"}], "href": "https://doi.org/10.1038/ng.361"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19430483"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19430483"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "M Kamran Ikram, Xueling Sim, Richard A Jensen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1001184"}], "href": "https://doi.org/10.1371/journal.pgen.1001184"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21060863"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21060863"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Nicholas Eriksson, Joyce Y Tung, Amy K Kiefer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel associations for hypothyroidism include known autoimmune risk loci."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0034442"}], "href": "https://doi.org/10.1371/journal.pone.0034442"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22493691"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22493691"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Bethany L Dale, Meena S Madhur "}, {"type": "b", "children": [{"type": "t", "text": "Linking inflammation and hypertension via LNK/SH2B3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Opin Nephrol Hypertens (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MNH.0000000000000196"}], "href": "https://doi.org/10.1097/MNH.0000000000000196"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26717315"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26717315"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Wei Wang, Yang Tang, Ying Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LNK/SH2B3 Loss of Function Promotes Atherosclerosis and Thrombosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.116.308955"}], "href": "https://doi.org/10.1161/CIRCRESAHA.116.308955"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27430239"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27430239"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jennifer E Ho, Daniel Levy, Lynda Rose, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health Study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hypertens (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/HJH.0b013e3283406927"}], "href": "https://doi.org/10.1097/HJH.0b013e3283406927"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21045733"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21045733"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Patrick C A Dubois, Gosia Trynka, Lude Franke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multiple common variants for celiac disease influencing immune gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.543"}], "href": "https://doi.org/10.1038/ng.543"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20190752"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20190752"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Vesela Gateva, Johanna K Sandling, Geoff Hom, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.468"}], "href": "https://doi.org/10.1038/ng.468"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19838195"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19838195"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Daniel F Gudbjartsson, Unnur S Bjornsdottir, Eva Halapi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.323"}], "href": "https://doi.org/10.1038/ng.323"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19198610"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19198610"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Karen A Hunt, Alexandra Zhernakova, Graham Turner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Newly identified genetic risk variants for celiac disease related to the immune response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.102"}], "href": "https://doi.org/10.1038/ng.102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18311140"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18311140"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Alexandra Zhernakova, Clara C Elbers, Bart Ferwerda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evolutionary and functional analysis of celiac risk loci reveals SH2B3 as a protective factor against bacterial infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2010.05.004"}], "href": "https://doi.org/10.1016/j.ajhg.2010.05.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20560212"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20560212"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Beate Skinningsrud, Eystein S Husebye, Simon H Pearce, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms in CLEC16A and CIITA at 16p13 are associated with primary adrenal insufficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2008-0821"}], "href": "https://doi.org/10.1210/jc.2008-0821"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18593762"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18593762"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Edward J Carr, Heather A Niederer, Julie Williams, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Med Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2350-10-121"}], "href": "https://doi.org/10.1186/1471-2350-10-121"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19951419"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19951419"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "A Alcina, K Vandenbroeck, D Otaegui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Immun (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/gene.2010.30"}], "href": "https://doi.org/10.1038/gene.2010.30"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20508602"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20508602"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "J Romanos, D Barisani, G Trynka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Six new coeliac disease loci replicated in an Italian population confirm association with coeliac disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmg.2008.061457"}], "href": "https://doi.org/10.1136/jmg.2008.061457"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18805825"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18805825"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Anne Hinks, Paul Martin, Edward Flynn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Rheum Dis (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/ard.2009.126938"}], "href": "https://doi.org/10.1136/ard.2009.126938"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20647273"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20647273"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Elena Y Lavrikova, Alexey G Nikitin, Tamara L Kuraeva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The carriage of the type 1 diabetes-associated R262W variant of human LNK correlates with increased proliferation of peripheral blood monocytes in diabetic patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pediatr Diabetes (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1399-5448.2010.00656.x"}], "href": "https://doi.org/10.1111/j.1399-5448.2010.00656.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20546165"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20546165"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Takeji Umemura, Satoru Joshita, Hideaki Hamano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of autoimmune hepatitis with Src homology 2 adaptor protein 3 gene polymorphisms in Japanese patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jhg.2017.74"}], "href": "https://doi.org/10.1038/jhg.2017.74"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28703133"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28703133"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Stephen T Oh, Erin F Simonds, Carol Jones, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2010-02-270108"}], "href": "https://doi.org/10.1182/blood-2010-02-270108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20404132"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20404132"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "A Pardanani, T Lasho, C Finke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LNK mutation studies in blast-phase myeloproliferative neoplasms, and in chronic-phase disease with TET2, IDH, JAK2 or MPL mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/leu.2010.163"}], "href": "https://doi.org/10.1038/leu.2010.163"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20724988"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20724988"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Arianne Perez-Garcia, Alberto Ambesi-Impiombato, Michael Hadler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic loss of SH2B3 in acute lymphoblastic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2013-05-500850"}], "href": "https://doi.org/10.1182/blood-2013-05-500850"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23908464"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23908464"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Sigal Gery, Qi Cao, Saskia Gueller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Leukoc Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1189/jlb.0908575"}], "href": "https://doi.org/10.1189/jlb.0908575"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19293402"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19293402"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Ying Cheng, Kudakwashe Chikwava, Chao Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI81468"}], "href": "https://doi.org/10.1172/JCI81468"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26974155"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26974155"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Mary Frances McMullin, Holger Cario "}, {"type": "b", "children": [{"type": "t", "text": "LNK mutations and myeloproliferative disorders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hematol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajh.24259"}], "href": "https://doi.org/10.1002/ajh.24259"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26660394"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26660394"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Zheng Ge, Yan Gu, Lichan Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Co-existence of IL7R high and SH2B3 low expression distinguishes a novel high-risk acute lymphoblastic leukemia with Ikaros dysfunction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.10014"}], "href": "https://doi.org/10.18632/oncotarget.10014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27322554"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27322554"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "L B Baughn, M M Meredith, L Oseth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SH2B3 aberrations enriched in iAMP21 B lymphoblastic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cancergen.2018.05.004"}], "href": "https://doi.org/10.1016/j.cancergen.2018.05.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30005852"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30005852"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Yan Chen, Fang Fang, Yang Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Polymorphisms in LNK Gene Correlated to the Clinical Type of Myeloproliferative Neoplasms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0154183"}], "href": "https://doi.org/10.1371/journal.pone.0154183"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27111338"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27111338"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Juliette Fitau, Gwénola Boulday, Flora Coulon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The adaptor molecule Lnk negatively regulates tumor necrosis factor-alpha-dependent VCAM-1 expression in endothelial cells through inhibition of the ERK1 and -2 pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M510997200"}], "href": "https://doi.org/10.1074/jbc.M510997200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16644735"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16644735"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Julie Devallière, Mathias Chatelais, Juliette Fitau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LNK (SH2B3) is a key regulator of integrin signaling in endothelial cells and targets α-parvin to control cell adhesion and migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.11-193383"}], "href": "https://doi.org/10.1096/fj.11-193383"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22441983"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22441983"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Suna Lahut, Özgür Ömür, Özgün Uyan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ATXN2 and its neighbouring gene SH2B3 are associated with increased ALS risk in the Turkish population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0042956"}], "href": "https://doi.org/10.1371/journal.pone.0042956"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22916186"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22916186"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "I D Buysschaert, V Grulois, P Eloy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic evidence for a role of IL33 in nasal polyposis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Allergy (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1398-9995.2009.02227.x"}], "href": "https://doi.org/10.1111/j.1398-9995.2009.02227.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19860791"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19860791"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Ling-Wen Ding, Qiao-Yang Sun, Jarem J Edwards, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LNK suppresses interferon signaling in melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-019-09711-y"}], "href": "https://doi.org/10.1038/s41467-019-09711-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31110180"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31110180"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Mathias Chatelais, Julie Devallière, Cesare Galli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene transfer of the adaptor Lnk (SH2B3) prevents porcine endothelial cell activation and apoptosis: implication for xenograft's cytoprotection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Xenotransplantation (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1399-3089.2011.00629.x"}], "href": "https://doi.org/10.1111/j.1399-3089.2011.00629.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21496118"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21496118"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Hani Harb, Bilal Alashkar Alhamwe, Nathalie Acevedo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic Modifications in Placenta are Associated with the Child's Sensitization to Allergens."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2019/1315257"}], "href": "https://doi.org/10.1155/2019/1315257"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31111043"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31111043"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Tien-Cheng Wang, Hsun Chiu, Yu-Jung Chang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The adaptor protein SH2B3 (Lnk) negatively regulates neurite outgrowth of PC12 cells and cortical neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0026433"}], "href": "https://doi.org/10.1371/journal.pone.0026433"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22028877"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22028877"}]}]}]}