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In this way, SH3KBP1 fine‐tunes critical signaling cascades initiated by receptors such as the epidermal growth factor receptor, hepatocyte growth factor receptor, and TGF‑β receptors, ensuring that ligand‐induced signal transduction is appropriately arrested once the receptor is activated."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its pivotal role in receptor trafficking, SH3KBP1 serves as an essential platform for the assembly of signaling complexes that couple receptors to cytoskeletal and immune effector pathways. Through its multiple Src homology 3 (SH3) domains it binds proline‐rich motifs on partners such as CD2AP, SLP65/BLNK, and related proteins—thereby modulating immune receptor (B‐ and T‐cell) signaling, calcium mobilization, and NF‑κB activation. 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