{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent integrative analyses of publicly available datasets have identified the long non‐coding RNA SH3PXD2A‐AS1 as a novel molecule associated with disease progression in distinct pathological contexts. In colorectal cancer (CRC), aberrant expression of SH3PXD2A‐AS1 correlates with aggressive tumor behavior and progression, suggesting that this lncRNA may contribute to CRC metastasis and serve as a potential novel biomarker or therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn an independent study investigating placental dysfunction in early‐onset severe preeclampsia, elevated levels of SH3PXD2A‐AS1 were found to be positively correlated with clinical severity. Mechanistic investigations revealed that SH3PXD2A‐AS1 impairs trophoblast invasion and migration by recruiting the CCCTC-binding factor (CTCF) to the promoters of SH3PXD2A and CCR7, thereby repressing their transcription. This inhibitory action may contribute to insufficient placentation and the pathogenesis of preeclampsia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhonghua Ma, Peng Peng, Jing Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Non-Coding RNA SH3PXD2A-AS1 Promotes Cell Progression Partly Through Epigenetic Silencing P57 and KLF2 in Colorectal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000489589"}], "href": "https://doi.org/10.1159/000489589"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29734178"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29734178"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Qian Chen, Sijia Jiang, Haihua Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of lncRNA SH3PXD2A-AS1 with preeclampsia and its function in invasion and migration of placental trophoblast cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-02796-0"}], "href": "https://doi.org/10.1038/s41419-020-02796-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32719429"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32719429"}]}]}]}