{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA review of the provided abstracts reveals extensive investigations into the biological roles of various proteolytic enzymes—such as neprilysin (Mme), neprilysin 2 (NEP2), and NL1—in neural, vascular, and reproductive contexts. These studies describe how these proteases contribute to neural circuit function through remodeling of the perineuronal net, the degradation of amyloid‐β peptides implicated in Alzheimer’s disease, and modulation of sperm function and early embryonic development. However, none of the abstracts contain any information, experimental evidence, or discussion regarding the protein SHLD2P3. Consequently, no conclusions can be drawn from this collection of literature about the function or physiological role of SHLD2P3."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mélanie Carpentier, Christine Guillemette, Janice L Bailey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduced fertility in male mice deficient in the zinc metallopeptidase NL1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.24.10.4428-4437.2004"}], "href": "https://doi.org/10.1128/MCB.24.10.4428-4437.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15121861"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15121861"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Stéphanie Voisin, Tanja Ouimet "}, {"type": "b", "children": [{"type": "t", "text": "The ultimate tryptophan residue of neprilysin 2 is not involved in protein maturation and enzymatic activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2005.07.081"}], "href": "https://doi.org/10.1016/j.bbrc.2005.07.081"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16081046"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16081046"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Kentaro Oh-hashi, Kazumi Ohkubo, Kaoru Shizu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Biosynthesis, processing, trafficking, and enzymatic activity of mouse neprilysin 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-008-9747-z"}], "href": "https://doi.org/10.1007/s11010-008-9747-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18425424"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18425424"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Leah R Hanson, Daniel Hafez, Aleta L Svitak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Intranasal phosphoramidon increases beta-amyloid levels in wild-type and NEP/NEP2-deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Neurosci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12031-010-9460-8"}], "href": "https://doi.org/10.1007/s12031-010-9460-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20941644"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20941644"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Daniel Hafez, Jeffrey Y Huang, Alexis M Huynh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neprilysin-2 is an important β-amyloid degrading enzyme."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajpath.2010.11.012"}], "href": "https://doi.org/10.1016/j.ajpath.2010.11.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21224067"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21224067"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "J Rossier, A Bernard, J-H Cabungcal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8, Adamts15 and Neprilysin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/mp.2014.162"}], "href": "https://doi.org/10.1038/mp.2014.162"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25510509"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25510509"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Markus Krohn, Alexander Bracke, Yosef Avchalumov, et al. 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