SIPA1 Gene

Name	signal-induced proliferation-associated 1
Description	The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSIPA1 (signal‐induced proliferation‐associated protein 1) acts as a Rap GTPase‐activating protein that orchestrates essential signaling cascades regulating cell adhesion, cell cycle progression, and migration. Biochemical studies have demonstrated that SIPA1 interacts with chromatin‐regulatory partners such as BRD4, and that it shuttles to the nucleus via a unique noncanonical localization region. In the nucleus SIPA1 binds specific DNA motifs to modulate transcription of key genes—including integrin β1, fibronectin 1, and ABCB1—thereby influencing processes from focal adhesion turnover to the acquisition of drug‐resistant phenotypes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMultiple lines of evidence have implicated SIPA1 in the metastatic progression of various cancers. For instance, experimental murine mammary tumor models show that SIPA1 modulates metastatic efficiency, while genetic polymorphism studies in breast, lung, colorectal, and oral cancers reveal that specific SIPA1 variants are associated with aggressive tumor behavior, increased invasion, and poorer clinical outcome. In addition, SIPA1 is linked functionally to key downstream effectors—including focal adhesion kinase, Akt, and matrix metalloproteinases—and interacts with alternative isoforms of metastasis‐associated proteins (such as the pro‐metastatic BRD4 short isoform) to further drive the invasive cascade. Meta‐analyses of SIPA1 genetic variants and studies in gastric tumors further suggest that altered SIPA1 expression may correlate with aberrant angiogenesis and tumor progression in a context‐dependent manner."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in adhesion and invasion, SIPA1 contributes to the maintenance of cancer cell stemness and modulates therapeutic responses. Studies in human embryonic stem cells and breast cancer models indicate that SIPA1 promotes stem‐like features—via upregulation of SMAD2 and SMAD3 and activation of downstream transcriptional networks—which in turn reduce sensitivity to chemotherapeutic agents. These data highlight SIPA1 as a central modulator whose activity may serve both as a prognostic marker and as a potential therapeutic target to impair tumor progression and overcome drug resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Li Liu, Barbara R Schwartz, Joan Tupper, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The GTPase Rap1 regulates phorbol 12-myristate 13-acetate-stimulated but not ligand-induced beta 1 integrin-dependent leukocyte adhesion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M206208200"}], "href": "https://doi.org/10.1074/jbc.M206208200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12091396"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12091396"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Andrea Farina, Masakazu Hattori, Jun Qin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bromodomain protein Brd4 binds to GTPase-activating SPA-1, modulating its activity and subcellular localization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.24.20.9059-9069.2004"}], "href": "https://doi.org/10.1128/MCB.24.20.9059-9069.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15456879"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15456879"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Y Zhang, Y Gong, D Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear SIPA1 activates integrin β1 promoter and promotes invasion of breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2014.36"}], "href": "https://doi.org/10.1038/onc.2014.36"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24704834"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24704834"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ying Ma, Jun Weng, Ning Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel nuclear localization region in SIPA1 determines protein nuclear distribution and epirubicin-sensitivity of breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Macromol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ijbiomac.2021.03.101"}], "href": "https://doi.org/10.1016/j.ijbiomac.2021.03.101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33753200"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33753200"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Lijuan Guo, Wanjun Zhang, Xue Zhang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/bcr1389"}], "href": "https://doi.org/10.1186/bcr1389"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16563182"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16563182"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Mia M Gaudet, Kent Hunter, Paul Pharoah, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variation in SIPA1 in relation to breast cancer risk and survival after breast cancer diagnosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.23919"}], "href": "https://doi.org/10.1002/ijc.23919"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19089925"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19089925"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Szu-Min Hsieh, Robert A Smith, Nicholas A Lintell, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms in MMP9 and SIPA1 are associated with increased risk of nodal metastases in early-stage cervical cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gynecol Oncol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygyno.2009.09.037"}], "href": "https://doi.org/10.1016/j.ygyno.2009.09.037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19906411"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19906411"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Ke Ji, Lin Ye, Anne-Marie Toms, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of signal-induced proliferation-associated gene 1 (SIPA1), a RapGTPase-activating protein, is increased in colorectal cancer and has diverse effects on functions of colorectal cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Genomics Proteomics (2012)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22990111"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22990111"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Renling Pei, Ye Xu, Yan Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of SIPA1 545 C > T polymorphism with survival in Chinese women with metastatic breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11684-013-0247-5"}], "href": "https://doi.org/10.1007/s11684-013-0247-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23358895"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23358895"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Chenli Xie, Lei Yang, Xiaorong Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sipa1 promoter polymorphism predicts risk and metastasis of lung cancer in Chinese."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Carcinog (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mc.22039"}], "href": "https://doi.org/10.1002/mc.22039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23661532"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23661532"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Sheng-Ming Yi, Gui-Yuan Li "}, {"type": "b", "children": [{"type": "t", "text": "The association of SIPA1 gene polymorphisms with breast cancer risk: evidence from published studies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-013-1061-z"}], "href": "https://doi.org/10.1007/s13277-013-1061-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24006220"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24006220"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jude Alsarraj, Farhoud Faraji, Thomas R Geiger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BRD4 short isoform interacts with RRP1B, SIPA1 and components of the LINC complex at the inner face of the nuclear membrane."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0080746"}], "href": "https://doi.org/10.1371/journal.pone.0080746"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24260471"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24260471"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Agnieszka Gdowicz-Kłosok, Monika Giglok, Anna Drosik, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The SIPA1 -313A>G polymorphism is associated with prognosis in inoperable non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-014-2753-8"}], "href": "https://doi.org/10.1007/s13277-014-2753-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25352027"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25352027"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Rasa Ugenskienė, Dana Myrzaliyeva, Roberta Jankauskaitė, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The contribution of SIPA1 and RRP1B germline polymorphisms to breast cancer phenotype, lymph node status and survival in a group of Lithuanian young breast cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomarkers (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/1354750X.2016.1141989"}], "href": "https://doi.org/10.3109/1354750X.2016.1141989"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26901824"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26901824"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Toshikazu Takahara, Atsushi Kasamatsu, Masanobu Yamatoji, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Spa-1 regulates the maintenance and differentiation of human embryonic stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Dev Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1387/ijdb.072274yl"}], "href": "https://doi.org/10.1387/ijdb.072274yl"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18033671"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18033671"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Ning Wang, Jun Weng, Jing Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SIPA1 enhances SMAD2/3 expression to maintain stem cell features in breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cell Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.scr.2020.102099"}], "href": "https://doi.org/10.1016/j.scr.2020.102099"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33296812"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33296812"}]}]}]}
Synonyms	SPA1
Proteins	SIPA1_HUMAN
NCBI Gene ID	6494
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SIPA1 has 6,670 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 124 datasets.

Click the + buttons to view associations for SIPA1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SIPA1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SIPA1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SIPA1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SIPA1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SIPA1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SIPA1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SIPA1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SIPA1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SIPA1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SIPA1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SIPA1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SIPA1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SIPA1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SIPA1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SIPA1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SIPA1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SIPA1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with SIPA1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of SIPA1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing SIPA1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SIPA1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SIPA1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing SIPA1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing SIPA1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SIPA1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SIPA1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SIPA1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SIPA1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with SIPA1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of SIPA1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SIPA1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SIPA1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SIPA1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SIPA1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SIPA1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SIPA1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SIPA1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SIPA1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SIPA1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SIPA1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with SIPA1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.