{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSKA2 is a critical component of the spindle and kinetochore‐associated (Ska) complex that ensures proper mitotic progression. It contributes to accurate chromosome segregation by stabilizing kinetochore–microtubule attachments and promoting spindle checkpoint silencing, thereby permitting timely anaphase onset. Structural studies reveal that the Ska complex forms a distinctive, dimeric, coiled‐coil assembly with bipartite microtubule–binding domains, and its function is dynamically modulated by phosphorylation events and transcriptional control (including regulation via intronic miR‐301) as well as by glucocorticoid receptor interactions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its canonical mitotic role, aberrant regulation and epigenetic modification of SKA2 have been implicated in stress‐related and neuropsychiatric conditions. Multiple studies have demonstrated that increased DNA methylation and altered expression of SKA2 in blood and brain samples are associated with suicidal behavior, post‐traumatic stress disorder, and blunted cortisol reactivity. In these contexts, SKA2 epigenetic dysregulation—modulated by genetic polymorphisms and life‐threatening trauma—may serve as a promising biomarker linking hypothalamic–pituitary–adrenal axis dysfunction to psychiatric vulnerability and neuroinflammation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "15"}]}, {"type": "t", "text": "\n\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition, SKA2 plays a multifaceted role in tumorigenesis and other disease processes. Overexpression of SKA2—often in concert with its bidirectional partner PRR11 and under the regulatory influence of factors such as NF‐Y, p53, and CREB—has been linked to enhanced cell proliferation, migration, invasion, and metastatic potential across a range of malignancies including lung, breast, hepatocellular, and renal cancers. Moreover, non‐coding RNAs (for example, lncRNA SPRY4‐IT1) further modulate SKA2 expression to promote oncogenic signaling via pathways such as Wnt/β‐catenin. SKA2’s involvement also extends to other biological processes such as hematopoietic maturation, underscoring its broader significance as both a driver of disease progression and a potential therapeutic target."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "27"}]}, {"type": "t", "text": "\n\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Anja Hanisch, Herman H W Silljé, Erich A Nigg "}, {"type": "b", "children": [{"type": "t", "text": "Timely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7601426"}], "href": "https://doi.org/10.1038/sj.emboj.7601426"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17093495"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17093495"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lisa Rice, Charlotte E Waters, Jennifer Eccles, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Cyclic AMP responsive element-binding protein promotes renal cell carcinoma proliferation probably via the expression of spindle and kinetochore-associated protein 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.7017"}], "href": "https://doi.org/10.18632/oncotarget.7017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26824422"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26824422"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Er-Bao Bian, Chun-Chun Ma, Xiao-Jun He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic modification of miR-141 regulates SKA2 by an endogenous 'sponge' HOTAIR in glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.8895"}], "href": "https://doi.org/10.18632/oncotarget.8895"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27121316"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27121316"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Yitao Wang, Huali Weng, Ying Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The PRR11-SKA2 Bidirectional Transcription Unit Is Negatively Regulated by p53 through NF-Y in Lung Cancer Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms18030534"}], "href": "https://doi.org/10.3390/ijms18030534"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28257042"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28257042"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Philip Auckland, Nicholas I Clarke, Stephen J Royle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Congressing kinetochores progressively load Ska complexes to prevent force-dependent detachment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201607096"}], "href": "https://doi.org/10.1083/jcb.201607096"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28495837"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28495837"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Haihua Wu, Yueyue Wang, Tiantian Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The N-terminal polypeptide derived from vMIP-II exerts its anti-tumor activity in human breast cancer by regulating lncRNA SPRY4-IT1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20180411"}], "href": "https://doi.org/10.1042/BSR20180411"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30104400"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30104400"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Zhouhui Ren, Tong Yang, Pingping Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SKA2 mediates invasion and metastasis in human breast cancer via EMT."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2018.9623"}], "href": "https://doi.org/10.3892/mmr.2018.9623"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30387823"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30387823"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Yitao Wang, Chunxu Zhang, Li Mai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PRR11 and SKA2 gene pair is overexpressed and regulated by p53 in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMB Rep (2019)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30760381"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30760381"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "D Wang, Y J Suo, L Gong, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "The Shift of HbF to HbA under Influence of SKA2 Gene; A Possible Link between Cortisol and Hematopoietic Maturation in Term and Preterm Newborns."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocr Metab Immune Disord Drug Targets (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/1871530320666200504091354"}], "href": "https://doi.org/10.2174/1871530320666200504091354"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32364083"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32364083"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Jiong Jiang, Bing Xu, Ying Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Spindle and kinetochore-associated protein 2 facilitates the proliferation and invasion of hepatocellular carcinoma via the regulation of Wnt/β-catenin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2020.112181"}], "href": "https://doi.org/10.1016/j.yexcr.2020.112181"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32682011"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32682011"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Carmel Kalla, Tanya Goltser-Dubner, Dalya Pevzner, et al. 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