{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations have revealed that SLC25A21‐AS1, a long noncoding RNA (lncRNA), plays an important role in modulating tumor behavior. In gastric cancer (GC), SLC25A21‐AS1 expression is typically reduced in cancerous tissues and cells compared to normal counterparts; however, its level increases following radiation treatment. Overexpression of SLC25A21‐AS1 in GC cells enhances radiosensitivity by promoting DNA damage, inhibiting proliferation, and inducing apoptosis. Mechanistically, it acts as a molecular sponge for microRNA‐15a‐5p, thereby relieving suppression on its downstream target SNCG—a protein whose increased expression contributes to the radiosensitizing and tumor‑suppressive effects observed in GC cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn gliomas, downregulation of SLC25A21‐AS1 is a common finding and is significantly associated with advanced World Health Organization stage, unfavorable isocitrate dehydrogenase (IDH) status, and poorer overall and disease‑free survival outcomes. Functional studies in glioma models demonstrate that overexpression of SLC25A21‐AS1 inhibits cell proliferation, invasion, and migration. This tumor‑suppressive activity is at least partly mediated through its interaction with target microRNAs, miR‑221‑3p and miR‑222‑3p, whose activity counteracts the growth‐inhibitory effects of SLC25A21‐AS1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, these findings suggest that SLC25A21‐AS1 functions as a crucial molecular regulator in different cancer contexts. In gastric cancer, it enhances radiosensitivity and impedes tumor malignancy through the miR‑15a‑5p/SNCG axis, whereas in glioma, its reduced expression correlates with aggressive tumor behavior and poor patient prognosis via modulation of the miR‑221‑3p/miR‑222‑3p pathway. These studies underscore the potential of SLC25A21‐AS1 as both a prognostic biomarker and a therapeutic target in cancer management."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ling Wang, Zhiqiang Wang, Lin Wang "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA Solute Carrier Family 25 Member 21 Antisense RNA 1 Inhibits Cell Malignant Behaviors and Enhances Radiosensitivity of Gastric Cancer Cells by Upregulating Synuclein Gamma Expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tohoku J Exp Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1620/tjem.2022.J029"}], "href": "https://doi.org/10.1620/tjem.2022.J029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35444105"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35444105"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mingtao Zhu, Kunrong Li, Jing Zhang "}, {"type": "b", "children": [{"type": "t", "text": "Gliomas with Downregulation of lncRNA SLC25A21-AS1 Carry a Dismal Prognosis and an Accelerated Progression in Cell Proliferation, Migration and Invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biotechnol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12033-022-00472-6"}], "href": "https://doi.org/10.1007/s12033-022-00472-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35266110"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35266110"}]}]}]}