{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn hepatocellular carcinoma (HCC), the long noncoding RNA SLC2A1‐AS1 is frequently downregulated, and its restoration leads to a suppression of glycolysis and tumor progression. Mechanistically, SLC2A1‐AS1 reduces the expression of the glucose transporter GLUT1, thereby limiting glucose uptake, lactate production, and ATP generation. This RNA exerts its effect by competitively binding to regulatory proteins such as transketolase and STAT3, which in turn inhibits the transcriptional activation of FOXM1—ultimately inactivating the FOXM1/GLUT1 axis and suppressing HCC cell proliferation and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "In contrast, in lung adenocarcinoma (LUAD) and other cancers including lung squamous cell carcinoma and pancreatic adenocarcinoma, SLC2A1‐AS1 is notably overexpressed and acts as an oncogene. Here, its transcription is positively regulated by the transcription factor TFAP2A, and the RNA predominantly localizes in the cytoplasm where it binds to miR-508-5p, effectively reducing the miRNA's inhibitory effect on cell proliferation. This TFAP2A-mediated upregulation of SLC2A1‐AS1 drives cancer cell growth and is associated with poorer overall survival, highlighting the context-dependent dual functionality of this lncRNA."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Runze Shang, Miao Wang, Bin Dai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA SLC2A1-AS1 regulates aerobic glycolysis and progression in hepatocellular carcinoma via inhibiting the STAT3/FOXM1/GLUT1 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.12666"}], "href": "https://doi.org/10.1002/1878-0261.12666"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32174012"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32174012"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yuanbo Cui, Chunyan Zhang, Shanshan Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TFAP2A-induced SLC2A1-AS1 promotes cancer cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Chem (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1515/hsz-2020-0290"}], "href": "https://doi.org/10.1515/hsz-2020-0290"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33580997"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33580997"}]}]}]}