SLC49A4 Gene

Name solute carrier family 49 member 4
Description This gene encodes a membrane-bound protein from the major facilitator superfamily of transporters. Disruption of this gene by translocation has been associated with haplo-insufficiency and renal cell carcinomas. Alternatively spliced transcript variants have been described, but their biological validity has not yet been determined. [provided by RefSeq, Jul 2008]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA review of the provided literature reveals an extensive body of work characterizing the mechanisms by which costimulatory molecules—including members of the B7:CD28 family such as CD80 (B7‐1), CD86 (B7‐2), PD‐L1, and their receptors (CD28, CTLA‐4, PD‐1)—regulate T‐cell activation, tolerance, and effector functions in numerous disease models spanning autoimmunity, tumor immunity, graft‐versus‐host disease, and infectious disease. These studies detail, for example, how bidirectional interactions (e.g., PD‐L1 with B7‐1), trans‐endocytosis via CTLA‐4, and nuanced tissue‐specific roles of donor versus host antigen–presenting cells modulate immune responses (for instance, see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNotably, however, none of these abstracts contains any reference to or discussion of SLC49A4. Despite the rich insights into immunologic costimulation and checkpoint regulation described in these studies, there is no information provided regarding SLC49A4—an orphan member of the solute carrier family—in the context of immune cell signaling or metabolism. In other words, while the articles collectively expand our understanding of how costimulatory pathways shape T‐cell responses and immune homeostasis, they do not address a functional role for SLC49A4, leaving its biological significance in these processes still undetermined."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jochen Reiser, Gero von Gersdorff, Martin Loos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Induction of B7-1 in podocytes is associated with nephrotic syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI20402"}], "href": "https://doi.org/10.1172/JCI20402"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15146236"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15146236"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shin-Ichiro Fujii, Kang Liu, Caroline Smith, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20040317"}], "href": "https://doi.org/10.1084/jem.20040317"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15197224"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15197224"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Silke Paust, Linrong Lu, Nami McCarty, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0403342101"}], "href": "https://doi.org/10.1073/pnas.0403342101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15235129"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15235129"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Britt E Anderson, Jennifer M McNiff, Dhanpat Jain, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2004-08-3032"}], "href": "https://doi.org/10.1182/blood-2004-08-3032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15522961"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15522961"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Manish J Butte, Mary E Keir, Theresa B Phamduy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2007.05.016"}], "href": "https://doi.org/10.1016/j.immuni.2007.05.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17629517"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17629517"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Matthias T Stephan, Vladimir Ponomarev, Renier J Brentjens, et al. "}, {"type": "b", "children": [{"type": "t", "text": "T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm1676"}], "href": "https://doi.org/10.1038/nm1676"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18026115"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18026115"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Antony Vinh, Wei Chen, Yelena Blinder, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition and genetic ablation of the B7/CD28 T-cell costimulation axis prevents experimental hypertension."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCULATIONAHA.109.930446"}], "href": "https://doi.org/10.1161/CIRCULATIONAHA.109.930446"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21126972"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21126972"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Omar S Qureshi, Yong Zheng, Kyoko Nakamura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1202947"}], "href": "https://doi.org/10.1126/science.1202947"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21474713"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21474713"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Alison M Paterson, Keturah E Brown, Mary E Keir, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The programmed death-1 ligand 1:B7-1 pathway restrains diabetogenic effector T cells in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1003496"}], "href": "https://doi.org/10.4049/jimmunol.1003496"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21697456"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21697456"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Aline Bozec, Mario M Zaiss, Rosebeth Kagwiria, et al. "}, {"type": "b", "children": [{"type": "t", "text": "T cell costimulation molecules CD80/86 inhibit osteoclast differentiation by inducing the IDO/tryptophan pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Transl Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scitranslmed.3007764"}], "href": "https://doi.org/10.1126/scitranslmed.3007764"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24807557"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24807557"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Ruishu Deng, Kaniel Cassady, Xiaofan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "B7H1/CD80 interaction augments PD-1-dependent T cell apoptosis and ameliorates graft-versus-host disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1402157"}], "href": "https://doi.org/10.4049/jimmunol.1402157"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25488990"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25488990"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Xiong Ni, Qingxiao Song, Kaniel Cassady, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PD-L1 interacts with CD80 to regulate graft-versus-leukemia activity of donor CD8+ T cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI91138"}], "href": "https://doi.org/10.1172/JCI91138"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28414296"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28414296"}]}]}]}
NCBI Gene ID 84925
API
Download Associations
Predicted Functions View SLC49A4's ARCHS4 Predicted Functions.
Co-expressed Genes View SLC49A4's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View SLC49A4's ARCHS4 Predicted Functions.

Functional Associations

SLC49A4 has 1,565 functional associations with biological entities spanning 6 categories (functional term, phrase or reference, chemical, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 29 datasets.

Click the + buttons to view associations for SLC49A4 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of SLC49A4 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
CCLE Cell Line Proteomics Cell lines associated with SLC49A4 protein from the CCLE Cell Line Proteomics dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of SLC49A4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
CM4AI KOLF21J CRISPRi Gene Perturbation Atlas gene perturbations changing expression of SLC49A4 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 cellular components containing SLC49A4 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with SLC49A4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
DeepCoverMOA Drug Mechanisms of Action small molecule perturbations with high or low expression of SLC49A4 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
DepMap CRISPR Gene Dependency cell lines with fitness changed by SLC49A4 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with SLC49A4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
GO Biological Process Annotations 2025 biological processes involving SLC49A4 gene from the curated GO Biological Process Annotations2025 dataset.
GO Cellular Component Annotations 2023 cellular components containing SLC49A4 protein from the curated GO Cellular Component Annotations 2023 dataset.
GO Cellular Component Annotations 2025 cellular components containing SLC49A4 protein from the curated GO Cellular Component Annotations 2025 dataset.
GTEx eQTL 2025 SNPs regulating expression of SLC49A4 gene from the GTEx eQTL 2025 dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of SLC49A4 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GWAS Catalog SNP-Phenotype Associations 2025 phenotypes associated with SLC49A4 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.
IMPC Knockout Mouse Phenotypes phenotypes of mice caused by SLC49A4 gene knockout from the IMPC Knockout Mouse Phenotypes dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of SLC49A4 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
JASPAR Predicted Mouse Transcription Factor Targets 2025 transcription factors regulating expression of SLC49A4 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
MGI Mouse Phenotype Associations 2023 phenotypes of transgenic mice caused by SLC49A4 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
MoTrPAC Rat Endurance Exercise Training tissue samples with high or low expression of SLC49A4 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset.
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles drug perturbations changing expression of SLC49A4 gene from the NIBR DRUG-seq U2OS MoA Box dataset.
Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of SLC49A4 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of SLC49A4 gene from the Rummagene Transcription Factor Associations 2026 dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of SLC49A4 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of SLC49A4 gene from the RummaGEO Gene Perturbation Signatures dataset.
Sci-Plex Drug Perturbation Signatures drug perturbations changing expression of SLC49A4 gene from the Sci-Plex Drug Perturbation Signatures dataset.
Tahoe Therapeutics Tahoe 100M Perturbation Atlas drug perturbations changing expression of SLC49A4 gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 tissues with high expression of SLC49A4 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with SLC49A4 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.