{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn gastric cancer, the long noncoding RNA SLC7A11‐AS1 plays a tumor‐suppressive role by modulating redox homeostasis and chemosensitivity. In resistant gastric cancer tissues and cell lines, SLC7A11‐AS1 is downregulated, which is accompanied by increased expression of xCT, enhanced glutathione (GSH) biosynthesis, and reduced intracellular reactive oxygen species (ROS) levels. Overexpression of SLC7A11‐AS1 suppresses xCT expression, reduces GSH production, increases ROS, and ultimately restores sensitivity to cisplatin-based chemotherapy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nConversely, in colorectal cancer, SLC7A11‐AS1 is significantly overexpressed and correlates positively with its sense transcript SLC7A11 as well as with nuclear NRF2 levels. This upregulation is associated with decreased cellular ROS and contributes to enhanced tumor cell proliferation, migration, and invasion, ultimately leading to poorer overall survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn hepatocellular carcinoma, SLC7A11‐AS1 exhibits oncogenic properties. Its expression is elevated via METTL3-mediated m6A modification, and it promotes tumor progression by downregulating the transcription factor KLF9 through modulation of STUB1-mediated ubiquitination. The loss of KLF9 subsequently reduces PHLPP2 levels, leading to activation of the AKT signaling pathway and further enhancing malignant behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yajun Luo, Wanping Xiang, Zilin Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional role of the SLC7A11-AS1/xCT axis in the development of gastric cancer cisplatin-resistance by a GSH-dependent mechanism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Free Radic Biol Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.freeradbiomed.2022.03.026"}], "href": "https://doi.org/10.1016/j.freeradbiomed.2022.03.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35367340"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35367340"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Tian Wang, Si Liang, Yajing Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of lncRNA SLC7A11-AS1 decreased the NRF2/SLC7A11 expression and inhibited the progression of colorectal cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.15216"}], "href": "https://doi.org/10.7717/peerj.15216"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37077308"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37077308"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Fan-Lin Zeng, Jie Lin, Xing Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SLC7A11-AS1 promotes the progression of hepatocellular carcinoma by mediating KLF9 ubiquitination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasma (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4149/neo_2023_230323N162"}], "href": "https://doi.org/10.4149/neo_2023_230323N162"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37498069"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37498069"}]}]}]}