{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe SLCO1B3‐SLCO1B7 readthrough transcript encodes a novel member of the Organic Anion Transporting Polypeptide (OATP) 1B subfamily that is expressed in the smooth endoplasmic reticulum of hepatocytes. This protein facilitates the transmembrane transport of dehydroepiandrosterone‐sulfate (DHEAS), and its unique linkage—derived from the fusion of SLCO1B3 and SLCO1B7 on chromosome 12—positions it as an important determinant in hepatic metabolism. Functional studies using heterologous expression systems have shown that naturally occurring coding polymorphisms within the SLCO1B7 region significantly reduce DHEAS transport activity. In particular, genetic variants such as 641 T, 1073 G, and 1775 A lead to a marked decrease in DHEAS accumulation, and a haplotype comprising 884A, 1073 G, and 1501C completely abolishes transporter function without impacting overall protein expression. These findings underscore the pharmacogenetic significance of this transporter, suggesting that genetic variability in SLCO1B3‐SLCO1B7 may influence drug disposition and endocrine regulation in vivo."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Henriette E Meyer Zu Schwabedissen, Isabell Seibert, Markus Grube, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variants of SLCO1B7 are of relevance for the transport function of OATP1B3-1B7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacol Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.phrs.2020.105155"}], "href": "https://doi.org/10.1016/j.phrs.2020.105155"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32818652"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32818652"}]}]}]}