SLCO4A1 Gene

HGNC Family	Solute carriers (SLC)
Name	solute carrier organic anion transporter family, member 4A1
Description	Enables organic anion transmembrane transporter activity and prostaglandin transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Predicted to be located in plasma membrane. Predicted to be active in basolateral plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSLCO4A1, a member of the organic anion transporting polypeptide family, mediates the uptake of a wide range of substrates including sugars, bile salts, organic acids, metal ions, and hormone conjugates such as estrone sulfate. Its expression appears tightly regulated during development; for example, in the human fetal cerebral cortex, OATP4A1 mRNA levels are reduced relative to adult tissue, underscoring a development‐specific modulation of organic anion transport (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn oncologic contexts, aberrant SLCO4A1 expression has been linked to tumor biology and patient outcomes. In lung-derived cancers, including non‐small cell lung cancer and carcinoid tumors, OATP4A1 is prominently expressed in both malignant and non‐malignant tissues, where its enhanced expression promotes cell proliferation, migration, and invasion—possibly via modulation of MAPK signaling—and is associated with a poor prognosis. In colorectal cancer, while an increase in OATP4A1 mRNA levels in cancerous tissue has been documented, higher protein abundance in tumor and adjacent immune cells correlates with a decreased risk of recurrence, suggesting a potential prognostic role (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in tumorigenesis, SLCO4A1 is implicated in physiological transport processes in other tissues. In the placenta, particularly under conditions of intrahepatic cholestasis of pregnancy, OATP4A1 mRNA levels show positive correlations with bile acid concentrations, hinting at a regulatory function to protect the fetus from excessive bile acid exposure. Collectively, these findings highlight that SLCO4A1 plays multifaceted roles in normal physiology—as a transporter regulating the uptake of diverse endogenous compounds—and in pathological states such as cancer and pregnancy-related cholestasis (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "S-Y Chan, A Martín-Santos, L S Loubière, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The expression of thyroid hormone transporters in the human fetal cerebral cortex during early development and in N-Tera-2 neurodifferentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Physiol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1113/jphysiol.2011.207290"}], "href": "https://doi.org/10.1113/jphysiol.2011.207290"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21486766"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21486766"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Agnieszka Anna Rawłuszko-Wieczorek, Nikodem Horst, Karolina Horbacka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of DNA methylation profile on OATP3A1 and OATP4A1 transcript levels in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2015.08.026"}], "href": "https://doi.org/10.1016/j.biopha.2015.08.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26349991"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26349991"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Myung Jin Ban, Sang Hee Ji, Chi-Kyu Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Solute carrier organic anion transporter family member 4A1 (SLCO4A1) as a prognosis marker of colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer Res Clin Oncol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00432-017-2393-7"}], "href": "https://doi.org/10.1007/s00432-017-2393-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28378090"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28378090"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Stefan Brenner, Lukas Klameth, Juliane Riha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Specific expression of OATPs in primary small cell lung cancer (SCLC) cells as novel biomarkers for diagnosis and therapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2014.09.025"}], "href": "https://doi.org/10.1016/j.canlet.2014.09.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25301452"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25301452"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Veronika Buxhofer-Ausch, Maidah Sheikh, Christoph Ausch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Abundance of the Organic Anion-transporting Polypeptide OATP4A1 in Early-Stage Colorectal Cancer Patients: Association With Disease Relapse."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Appl Immunohistochem Mol Morphol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/PAI.0000000000000557"}], "href": "https://doi.org/10.1097/PAI.0000000000000557"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29734253"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29734253"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Shihao Li, Zihao Li, Lan Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SLCO4A1, as a novel prognostic biomarker of non‑small cell lung cancer, promotes cell proliferation and migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2024.5618"}], "href": "https://doi.org/10.3892/ijo.2024.5618"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38275113"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38275113"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Edgar Ontsouka, Alessandra Epstein, Sampada Kallol, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Placental Expression of Bile Acid Transporters in Intrahepatic Cholestasis of Pregnancy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms221910434"}], "href": "https://doi.org/10.3390/ijms221910434"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34638773"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34638773"}]}]}]}
Synonyms	POAT, OATP1, OATP4A1, OATP-E, OATPRP1, SLC21A12, OATPE
Proteins	SO4A1_HUMAN
NCBI Gene ID	28231
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SLCO4A1 has 8,153 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 119 datasets.

Click the + buttons to view associations for SLCO4A1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SLCO4A1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by SLCO4A1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SLCO4A1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SLCO4A1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SLCO4A1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SLCO4A1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SLCO4A1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SLCO4A1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SLCO4A1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SLCO4A1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SLCO4A1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SLCO4A1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SLCO4A1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SLCO4A1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with SLCO4A1 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SLCO4A1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SLCO4A1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SLCO4A1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SLCO4A1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SLCO4A1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SLCO4A1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SLCO4A1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SLCO4A1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing SLCO4A1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SLCO4A1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SLCO4A1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SLCO4A1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SLCO4A1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SLCO4A1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SLCO4A1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with SLCO4A1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of SLCO4A1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SLCO4A1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SLCO4A1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SLCO4A1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SLCO4A1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SLCO4A1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SLCO4A1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for SLCO4A1 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SLCO4A1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SLCO4A1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.