{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLong noncoding RNAs (lncRNAs) have emerged as key regulators in tumorigenesis, and recent studies have begun to define the role of SLCO4A1‐AS1 in this context. In colorectal cancer (CRC), where many lncRNAs are known to be involved in malignant transformation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", SLCO4A1‐AS1 has been shown to promote tumor progression. Functionally, in CRC cells its knockdown represses cytoprotective autophagy and cell proliferation by directly targeting partition-defective 3 (PARD3) via a mechanism in which SLCO4A1‐AS1 sequesters miR‑508‑3p, leading to the upregulation of PARD3."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In colon cancer stem cells, SLCO4A1‐AS1 acts as a competing endogenous RNA by binding miR‑150‑3p, thereby elevating SLCO4A1 expression; this, in turn, enhances migration, invasion, sphere formation, and tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, its upregulation in CRC has been further underscored by additional profiling studies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond CRC, SLCO4A1‐AS1 has been implicated in the progression of multiple other malignancies. In non‐small‐cell lung cancer (NSCLC), elevated levels of SLCO4A1‐AS1 promote proliferation, migration, and invasion while simultaneously inhibiting apoptosis by sponging miR‑223‑3p; this results in enhanced expression of IKKα and subsequent activation of the NF‑κB signaling pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Similar regulatory functions have been suggested in hematologic and head and neck malignancies, with studies in acute lymphocytic leukemia (ALL) and laryngeal squamous cell carcinoma (LSCC) implicating SLCO4A1‐AS1 in tumorigenesis, though the specific downstream mechanisms remain to be fully elucidated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition, in melanoma, SLCO4A1‐AS1 has been identified as an oncogenic lncRNA that, when overexpressed, facilitates malignant behaviors. Mechanistic studies reveal that SLCO4A1‐AS1 acts by binding to miR‑1306‑5p, which results in the de-repression of polycomb group ring finger 2 (PCGF2). The ensuing upregulation of PCGF2 enhances melanoma cell proliferation, migration, and invasion while reducing apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jiangtao Yu, Zhiyang Han, Ziquan Sun, et al. 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