SLU7 Gene

Name	SLU7 splicing factor homolog (S. cerevisiae)
Description	Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSLU7 is a highly conserved splicing regulator that orchestrates accurate 3′ splice site selection, with distinct protein domains that control its nuclear localization and retention (as revealed by mutational analyses ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "]). It dynamically shuttles between the nucleus and cytoplasm—its nuclear concentration being modulated by stress conditions such as UV‐C exposure and other cellular stressors ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "]—and its expression is tightly controlled by transcription factors including Sp1 and Elk‑1 that dictate tissue‑specific alternative splicing ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "]. In yeast models, studies further imply that SLU7 has broad, intron‑specific roles that adjust splicing efficiency and fidelity ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "].\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the liver, SLU7 is pivotal for maintaining hepatocyte identity and metabolic homeostasis. Its expression underpins proper splicing of key differentiation factors—such as SRSF3 and HNF4α—thereby preserving a mature hepatic phenotype and quiescence ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "]. Loss or downregulation of SLU7 triggers a fetal-like gene expression pattern, impairs metabolic signaling, and fosters a tumor-like glycolytic state that can promote hepatocarcinogenesis ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "]. Moreover, in the context of alcoholic liver disease, reduced SLU7 levels lead to aberrant splicing of regulators such as SIRT1 and lipin‑1, culminating in heightened oxidative stress, inflammation, and liver injury ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "].\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its central role in pre‑mRNA splicing, SLU7 safeguards genome integrity by preventing the formation of R‑loops, DNA damage, and mitotic errors through the proper regulation of splicing factors and proteins essential for sister chromatid cohesion ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "]. In addition, SLU7 exerts epigenetic control by stabilizing DNMT1 and collaborating with chromatin modifiers such as UHRF1 and G9a to maintain correct DNA methylation patterns. This additional layer of regulation positions SLU7 as an integrative hub of gene expression, with implications for cell cycle progression and cancer cell survival—such that its altered expression is associated with malignant transformation and presents a potential therapeutic target ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "].\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Noam Shomron, Mika Reznik, Gil Ast "}, {"type": "b", "children": [{"type": "t", "text": "Splicing factor hSlu7 contains a unique functional domain required to retain the protein within the nucleus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e04-02-0152"}], "href": "https://doi.org/10.1091/mbc.e04-02-0152"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15181151"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15181151"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Noam Shomron, Moti Alberstein, Mika Reznik, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.01720"}], "href": "https://doi.org/10.1242/jcs.01720"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15728250"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15728250"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Aleksandra Janowicz, Marek Michalak, Joachim Krebs "}, {"type": "b", "children": [{"type": "t", "text": "Stress induced subcellular distribution of ALG-2, RBM22 and hSlu7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2010.11.010"}], "href": "https://doi.org/10.1016/j.bbamcr.2010.11.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21122810"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21122810"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Moti Alberstein, Maayan Amit, Keren Vaknin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of transcription of the RNA splicing factor hSlu7 by Elk-1 and Sp1 affects alternative splicing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "RNA (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1261/rna.492907"}], "href": "https://doi.org/10.1261/rna.492907"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17804646"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17804646"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Shataparna Banerjee, Piyush Khandelia, Geetha Melangath, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Splicing functions and global dependency on fission yeast slu7 reveal diversity in spliceosome assembly."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00007-13"}], "href": "https://doi.org/10.1128/MCB.00007-13"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23754748"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23754748"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "María Elizalde, Raquel Urtasun, María Azkona, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Splicing regulator SLU7 is essential for maintaining liver homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI74382"}], "href": "https://doi.org/10.1172/JCI74382"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24865429"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24865429"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "María Gárate-Rascón, Miriam Recalde, Maddalen Jimenez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte Nuclear Factor 4α Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.32029"}], "href": "https://doi.org/10.1002/hep.32029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34170569"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34170569"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "R Urtasun, M Elizalde, M Azkona, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Splicing regulator SLU7 preserves survival of hepatocellular carcinoma cells and other solid tumors via oncogenic miR-17-92 cluster expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2015.517"}], "href": "https://doi.org/10.1038/onc.2015.517"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26804174"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26804174"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jiayou Wang, Noah Kainrad, Hong Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hepatic Knockdown of Splicing Regulator Slu7 Ameliorates Inflammation and Attenuates Liver Injury in Ethanol-Fed Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajpath.2018.05.004"}], "href": "https://doi.org/10.1016/j.ajpath.2018.05.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29870742"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29870742"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Maddalen Jiménez, Raquel Urtasun, María Elizalde, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Splicing events in the control of genome integrity: role of SLU7 and truncated SRSF3 proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkz014"}], "href": "https://doi.org/10.1093/nar/gkz014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30657957"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30657957"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Miriam Recalde, María Gárate-Rascón, María Elizalde, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The splicing regulator SLU7 is required to preserve DNMT1 protein stability and DNA methylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkab649"}], "href": "https://doi.org/10.1093/nar/gkab649"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34331453"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34331453"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "María Gárate-Rascón, Miriam Recalde, Carla Rojo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SLU7: A New Hub of Gene Expression Regulation-From Epigenetics to Protein Stability in Health and Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms232113411"}], "href": "https://doi.org/10.3390/ijms232113411"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36362191"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36362191"}]}]}]}
Synonyms	HSLU7
Proteins	SLU7_HUMAN
NCBI Gene ID	10569
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SLU7 has 4,757 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 110 datasets.

Click the + buttons to view associations for SLU7 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SLU7 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by SLU7 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SLU7 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SLU7 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SLU7 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SLU7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SLU7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SLU7 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SLU7 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SLU7 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SLU7 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SLU7 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SLU7 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SLU7 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SLU7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SLU7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of SLU7 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing SLU7 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SLU7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SLU7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing SLU7 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SLU7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SLU7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing SLU7 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SLU7 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with SLU7 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of SLU7 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SLU7 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SLU7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SLU7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SLU7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SLU7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SLU7 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SLU7 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SLU7 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SLU7 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with SLU7 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing SLU7 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of SLU7 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of SLU7 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of SLU7 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.