{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn pancreatic cancer and oral squamous cell carcinoma, LINC01207 acts as an oncogenic long non‐coding RNA. In pancreatic cancer, it is highly expressed relative to adjacent tissues and functions by sponging miR‑143‑5p to upregulate AGR2, thereby promoting cell proliferation while suppressing apoptosis and autophagy. Similarly, in oral squamous cell carcinoma, elevated LINC01207 enhances cell viability, colony formation, and migration by interacting with miR‑1301‑3p to derepress LDHA, and its silencing leads to increased apoptotic and autophagic activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn gastric cancer, although LINC01207 has been identified as an oncogene in several malignancies, its specific molecular functions and underlying mechanisms remain poorly understood, warranting further investigation into its role in gastric tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nContrasting with its oncogenic roles in some cancers, in malignant glioma LINC01207 appears to function as a tumor suppressor. Lower expression of LINC01207 in glioma tissue is associated with unfavorable clinical features, including lower Karnofsky performance scores, increased invasion, and higher tumor grade. Functionally, reduced LINC01207 levels contribute to enhanced cell proliferation and metastatic potential, while its upregulation induces G0/G1 cell cycle arrest and represses epithelial-to-mesenchymal transition via modulation of the GSK‑3β/β‑catenin signaling pathway, collectively correlating with improved patient survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chang Liu, Jin-Ou Wang, Wen-Yang Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC01207 silencing suppresses AGR2 expression to facilitate autophagy and apoptosis of pancreatic cancer cells by sponging miR-143-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Endocrinol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mce.2019.04.004"}], "href": "https://doi.org/10.1016/j.mce.2019.04.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30991076"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30991076"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaolin Lu, Liling Chen, Yang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC01207 promotes cell proliferation and migration but suppresses apoptosis and autophagy in oral squamous cell carcinoma by the microRNA-1301-3p/lactate dehydrogenase isoform A axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1972784"}], "href": "https://doi.org/10.1080/21655979.2021.1972784"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34463208"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34463208"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lan Yu, Yanwei Gao, Beibei Ji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CTCF-induced upregulation of LINC01207 promotes gastric cancer progression via miR-1301-3p/PODXL axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dig Liver Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.dld.2020.12.006"}], "href": "https://doi.org/10.1016/j.dld.2020.12.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33495099"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33495099"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Dapeng Chi, Wei Zhang, Yulong Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01207 Predicts Poor Prognosis and Suppresses Cell Growth and Metastasis via Regulating GSK-3β/β-Catenin Signaling Pathway in Malignant Glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/MSM.923189"}], "href": "https://doi.org/10.12659/MSM.923189"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32533688"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32533688"}]}]}]}