{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSNHG10, a long noncoding RNA, plays diverse roles in tumorigenesis that vary in a context‐dependent manner. In hepatocellular carcinoma, SNHG10 acts as an oncogenic driver by sponging miR‑150‑5p and enhancing c‑Myb expression to promote tumor growth and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In gastric cancer, although its function is not yet fully elucidated, SNHG10 has been recognized as an oncogene, underscoring its potential as a diagnostic and therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In contrast, investigations in non‑small cell lung cancer (NSCLC) indicate that SNHG10 is downregulated, with low levels predicting poorer overall survival; here, SNHG10 appears to function as a tumor suppressor by sponging miR‑543 and ultimately upregulating the tumor‑suppressive sirtuin 1 (SIRT1)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Similarly, studies in osteosarcoma have aimed to decipher its role in modulating miR‑218"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", while in triple‑negative breast cancer (TNBC) SNHG10 is found downregulated—especially after doxorubicin treatment—and its overexpression leads to demethylation‐mediated upregulation of miR‑302b, promoting apoptosis and countering chemoresistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In castration‑resistant prostate cancer (CRPC), elevated SNHG10 in docetaxel‑resistant cells contributes to a resistant phenotype by acting as a molecular sponge for miR‑1271‑5p, thereby enhancing TRIM66 expression and facilitating glycolysis and cell survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its oncological implications, SNHG10 also contributes to myocardial injury. In a cardiomyocyte hypoxia/reoxygenation model with sevoflurane postconditioning, reduced SNHG10 levels are associated with protective effects against oxidative stress and inflammation. Conversely, SNHG10 overexpression impairs sevoflurane‑mediated protection by sponging miR‑495‑3p, which normally targets PTEN; this leads to increased PTEN expression, modified HIF‑1α levels, and ultimately exacerbated cardiomyocyte damage."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tian Lan, Kefei Yuan, Xiaokai Yan, et al. 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