{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSNHG12 is a long noncoding RNA that is aberrantly overexpressed in a wide range of malignancies—including osteosarcoma, hepatocellular carcinoma, papillary thyroid carcinoma, glioma, bladder, cervical, nasopharyngeal, natural killer/T‐cell lymphoma, prostate, ovarian, laryngeal, oral squamous, breast, pancreatic, renal, gastric, and non–small‐cell lung cancers—where its upregulation is strongly associated with enhanced tumor cell proliferation, migration, invasion, epithelial–mesenchymal transition (EMT) and therapeutic resistance. In these diverse cancers, elevated SNHG12 levels correlate with advanced clinical stage and poor prognosis, highlighting its oncogenic potential."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "32"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistically, SNHG12 functions primarily as a competing endogenous RNA (ceRNA). By sponging a broad array of tumor‐suppressive microRNAs—including but not limited to miR‑195‑5p, miR‑125b, miR‑101‑3p, miR‑129‑5p and miR‑16‑5p—it lifts the repression on multiple oncogenic targets such as Notch2, FOXP1, STAT3, WWP1, IGF1R, SALL4, COL11A1, IGF2 and CTNNB1. Moreover, SNHG12 has been shown to interact with RNA‐binding proteins like HuR to stabilize transcripts and activate critical signaling cascades (for example, the Notch, Wnt/β‑catenin, and PI3K/AKT pathways), thereby further promoting tumor progression and resistance to therapies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}, {"type": "fg_f", "ref": "5"}, {"type": "fg_f", "ref": "8"}, {"type": "fg_fs", "start_ref": "12", "end_ref": "15"}, {"type": "fg_f", "ref": "17"}, {"type": "fg_f", "ref": "19"}, {"type": "fg_fs", "start_ref": "21", "end_ref": "26"}, {"type": "fg_fs", "start_ref": "33", "end_ref": "35"}, {"type": "fg_fs", "start_ref": "27", "end_ref": "30"}, {"type": "fg_f", "ref": "36"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its prominent role in cancers, SNHG12 contributes to non‐malignant pathologies. In neuronal models—such as those of ischemic stroke and Parkinson’s disease—SNHG12 modulates apoptosis, inflammation, and oxidative stress by regulating microRNAs (e.g. influencing NEGR1 and NFIB expression). Likewise, in cardiovascular disorders such as atherosclerosis and hypertensive vascular injury, SNHG12 affects endothelial cell viability and vascular smooth muscle cell phenotype via miR‑25‑3p/SIRT6 and miR‑218‑5p/IGF2 axes, respectively; emerging evidence also suggests that it may play a role in preeclampsia and osteoarthritis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "38"}, {"type": "fg_f", "ref": "33"}, {"type": "fg_f", "ref": "39"}, {"type": "fg_f", "ref": "36"}, {"type": "fg_f", "ref": "40"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe clinical implications of SNHG12 are significant. Its consistent overexpression across diverse patient cohorts renders it a promising diagnostic and prognostic biomarker, while its central role in modulating key oncogenic and drug‐resistance pathways—such as those driving sunitinib resistance in renal cell carcinoma and cisplatin resistance in non–small‐cell lung cancer—points to its potential as a therapeutic target. Meta‐analyses and studies addressing its involvement in immune escape further consolidate its relevance in both tumor progression and potential treatment strategies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "41", "end_ref": "43"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wendong Ruan, Pei Wang, Shiqing Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA small nucleolar RNA host gene 12 (SNHG12) promotes cell proliferation and migration by upregulating angiomotin gene expression in human osteosarcoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-015-4256-7"}], "href": "https://doi.org/10.1007/s13277-015-4256-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26486328"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26486328"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Tian Lan, Weijie Ma, Zhenfei Hong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA small nucleolar RNA host gene 12 (SNHG12) promotes tumorigenesis and metastasis by targeting miR-199a/b-5p in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-016-0486-9"}], "href": "https://doi.org/10.1186/s13046-016-0486-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28073380"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28073380"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sheng Zhou, Ling Yu, Min Xiong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SNHG12 promotes tumorigenesis and metastasis in osteosarcoma by upregulating Notch2 by sponging miR-195-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2017.12.047"}], "href": "https://doi.org/10.1016/j.bbrc.2017.12.047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29229388"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29229388"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Shimei Ding, Wei Qu, Yang Jiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SNHG12 promotes the proliferation and metastasis of papillary thyroid carcinoma cells through regulating wnt/β-catenin signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biomark (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CBM-170777"}], "href": "https://doi.org/10.3233/CBM-170777"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29630517"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29630517"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Wei Lei, Zhi-Long Wang, He-Jun Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA SNHG12promotes the proliferation and migration of glioma cells by binding to HuR."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2018.4478"}], "href": "https://doi.org/10.3892/ijo.2018.4478"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30015836"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30015836"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yuchen Sun, Jian Liu, Liangzhao Chu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA SNHG12 facilitates the tumorigenesis of glioma through miR-101-3p/FOXP1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2018.08.034"}], "href": "https://doi.org/10.1016/j.gene.2018.08.034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30098431"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30098431"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Bin Jiang, Su Hailong, Jun Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of oncogenic long noncoding RNA SNHG12 and DUXAP8 in human bladder cancer through a comprehensive profiling analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2018.09.025"}], "href": "https://doi.org/10.1016/j.biopha.2018.09.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30243082"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30243082"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xue-J Jin, Xiang-J Chen, Zhi-F Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA SNHG12 promotes the progression of cervical cancer via modulating miR-125b/STAT3 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.27403"}], "href": "https://doi.org/10.1002/jcp.27403"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30246459"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30246459"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Zhi-Biao Liu, Chen Tang, Xin Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased expression of lncRNA SNHG12 predicts a poor prognosis of nasopharyngeal carcinoma and regulates cell proliferation and metastasis by modulating Notch signal pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biomark (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CBM-181873"}], "href": "https://doi.org/10.3233/CBM-181873"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30452404"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30452404"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Linan Zhu, Xudong Zhang, Xiaorui Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "c-Myc mediated upregulation of long noncoding RNA SNHG12 regulates proliferation and drug sensitivity in natural killer/T-cell lymphoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28529"}], "href": "https://doi.org/10.1002/jcb.28529"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30825244"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30825244"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jiannan Song, Xuhong Wu, Rong Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA SNHG12 promotes cell proliferation and activates Wnt/β-catenin signaling in prostate cancer through sponging microRNA-195."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28578"}], "href": "https://doi.org/10.1002/jcb.28578"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30945357"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30945357"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "D Sun, X-H Fan "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SNHG12 accelerates the progression of ovarian cancer via absorbing miRNA-129 to upregulate SOX4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201903_17378"}], "href": "https://doi.org/10.26355/eurrev_201903_17378"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30964158"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30964158"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Jing Li, Suguang Sun, Wei Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Small Nucleolar RNA Host Gene 12 (SNHG12) Promotes Proliferation and Invasion of Laryngeal Cancer Cells via Sponging miR-129-5p and Potentiating WW Domain-Containing E3 Ubiquitin Protein Ligase 1 (WWP1) Expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/MSM.917088"}], "href": "https://doi.org/10.12659/MSM.917088"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31348766"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31348766"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Xiaocheng Feng, Xuehong Dong, Dingting Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA small nucleolar RNA host gene 12 promotes papillary thyroid carcinoma cell growth and invasion by targeting miR-16-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histol Histopathol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14670/HH-18-155"}], "href": "https://doi.org/10.14670/HH-18-155"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31355416"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31355416"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Ning Xu, Jiayuan Xu, Zhuan Zuo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of lncRNA SNHG12 reversed IGF1R-induced osteosarcoma metastasis and proliferation by targeting miR-195-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2019.144145"}], "href": "https://doi.org/10.1016/j.gene.2019.144145"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31743769"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31743769"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jianqiu Liu, Xinyue Tang, Jing Lv, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNAs SNHG12 and LINC00152 were associated with progression of patients with papillary thyroid carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Future Oncol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2217/fon-2019-0016"}], "href": "https://doi.org/10.2217/fon-2019-0016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31773972"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31773972"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Shu-Yu Lai, Hong-Mei Guan, Jie Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA SNHG12 modulated by human papillomavirus 16 E6/E7 promotes cervical cancer progression via ERK/Slug pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29446"}], "href": "https://doi.org/10.1002/jcp.29446"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31943193"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31943193"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "M Liang, Z Pan, F Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA SNHG12 suppresses esophageal squamous cell carcinoma progression through competing endogenous RNA networks."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Transl Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12094-020-02317-7"}], "href": "https://doi.org/10.1007/s12094-020-02317-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32086782"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32086782"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Duoguang Wu, Xiaotian He, Wenjian Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA SNHG12 induces proliferation, migration, epithelial-mesenchymal transition, and stemness of esophageal squamous cell carcinoma cells via post-transcriptional regulation of BMI1 and CTNNB1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.12683"}], "href": "https://doi.org/10.1002/1878-0261.12683"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32239639"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32239639"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Yao Sun, Jin-Tao Zhao, Bao-Jin Chi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA SNHG12 promotes vascular smooth muscle cell proliferation and migration via regulating miR-199a-5p/HIF-1α."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cbin.11365"}], "href": "https://doi.org/10.1002/cbin.11365"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32339345"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32339345"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "J H Yuan, W X Li, C Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of SNHG12 accelerates cell proliferation, migration, invasion and restrain cell apoptosis in breast cancer by enhancing regulating SALL4 expression via sponging miR-15a-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasma (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4149/neo_2020_190808N731"}], "href": "https://doi.org/10.4149/neo_2020_190808N731"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32386479"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32386479"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Wei Cao, Guoxiong Zhou "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SNHG12 contributes proliferation, invasion and epithelial-mesenchymal transition of pancreatic cancer cells by absorbing miRNA-320b."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20200805"}], "href": "https://doi.org/10.1042/BSR20200805"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32432698"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32432698"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Yue Yin, Yingyun Tan, Yuan Yao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SNHG12/miR-326/E2F1 feedback loop facilitates the progression of oral squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oral Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/odi.13458"}], "href": "https://doi.org/10.1111/odi.13458"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32506729"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32506729"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Yuenan Liu, Gong Cheng, Ziwei Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA SNHG12 promotes tumour progression and sunitinib resistance by upregulating CDCA3 in renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-2713-8"}], "href": "https://doi.org/10.1038/s41419-020-2713-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32641718"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32641718"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Congjie Xu, Hui Liang, Jiaquan Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA small nucleolar RNA host gene 12 promotes renal cell carcinoma progression by modulating the miR‑200c‑5p/collagen type XI α1 chain pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2020.11490"}], "href": "https://doi.org/10.3892/mmr.2020.11490"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32901847"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32901847"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Pengyu Cai, Mingxiu Wu, Bin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non‑coding RNA SNHG12 regulates cell proliferation, invasion and migration in endometrial cancer by targeting miR‑4429."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2020.11370"}], "href": "https://doi.org/10.3892/mmr.2020.11370"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32945395"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32945395"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Ping-Ping Chen, Zhen-Sheng Zhang, Jin-Cai Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SNHG12 promotes proliferation and epithelial mesenchymal transition in hepatocellular carcinoma through targeting HEG1 via miR-516a-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2021.109992"}], "href": "https://doi.org/10.1016/j.cellsig.2021.109992"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33774129"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33774129"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Hongyuan Yu, Junlong Liu, Zhe Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SNHG12 promotes carcinogenesis of human renal cell cancer via functioning as a competing endogenous RNA and sponging miR-30a-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.16417"}], "href": "https://doi.org/10.1111/jcmm.16417"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33787057"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33787057"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Tianqi Zhang, Maneesh Kumarsing Beeharry, Zhenqiang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "YY1-modulated long non-coding RNA SNHG12 promotes gastric cancer metastasis by activating the miR-218-5p/YWHAZ axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijbs.58921"}], "href": "https://doi.org/10.7150/ijbs.58921"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33994849"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33994849"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Feng-Wen Xie, Ji-Chun Liu "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SNHG12 regulates the miR-101-3p/CUL4B axis to mediate the proliferation, migration and invasion of non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kaohsiung J Med Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/kjm2.12389"}], "href": "https://doi.org/10.1002/kjm2.12389"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34002487"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34002487"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Deli Tan, Gang Li, Peng Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SNHG12 in extracellular vesicles derived from carcinoma-associated fibroblasts promotes cisplatin resistance in non-small cell lung cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.2018099"}], "href": "https://doi.org/10.1080/21655979.2021.2018099"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35014944"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35014944"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Deli Tan, Song Wang, Peng Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SNHG12 Decreases Non-Small Cell Lung Cancer Cell Sensitivity to Cisplatin by Repressing miR-525-5p and Promoting XIAP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Clin Lab Sci (2023)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36889771"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36889771"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Yangtian Yan, Li Chen, Jiajun Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SNHG12 inhibits oxygen‑glucose deprivation‑induced neuronal apoptosis via the miR‑181a‑5p/NEGR1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2020.11459"}], "href": "https://doi.org/10.3892/mmr.2020.11459"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33000228"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33000228"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Wei Qian, Ze-Qi Zheng, Jun-Gang Nie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SNHG12 alleviates hypertensive vascular endothelial injury through miR-25-3p/SIRT6 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Leukoc Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/JLB.1A0820-501R"}], "href": "https://doi.org/10.1002/JLB.1A0820-501R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33464650"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33464650"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Ping Lu, Shihui Xiao, Shaoze Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SNHG12 downregulates RAGE to attenuate hypoxia-reoxygenation-induced apoptosis in H9c2 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Biotechnol Biochem (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/bbb/zbaa090"}], "href": "https://doi.org/10.1093/bbb/zbaa090"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33589923"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33589923"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Lei Yan, Lei Li, Jingan Lei "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA small nucleolar RNA host gene 12/microRNA-138-5p/nuclear factor I/B regulates neuronal apoptosis, inflammatory response, and oxidative stress in Parkinson's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.2005928"}], "href": "https://doi.org/10.1080/21655979.2021.2005928"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34783303"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34783303"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Wenbing Jiang, Wei Zhao, Fanhao Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SNHG12 regulates biological behaviors of ox-LDL-induced HA-VSMCs through upregulation of SPRY2 and NUB1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Atherosclerosis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.atherosclerosis.2021.11.006"}], "href": "https://doi.org/10.1016/j.atherosclerosis.2021.11.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34847450"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34847450"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Fenmei Zhou, Yanlan Sun, Zhenjing Chi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA SNHG12 promotes the proliferation, migration, and invasion of trophoblast cells by regulating the epithelial-mesenchymal transition and cell cycle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Int Med Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/0300060520922339"}], "href": "https://doi.org/10.1177/0300060520922339"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32529873"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32529873"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Ping Mao, Xiaowei Liu, Yingzheng Wen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SNHG12 regulates ox-LDL-induced endothelial cell injury by the miR-218-5p/IGF2 axis in atherosclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2021.1953755"}], "href": "https://doi.org/10.1080/15384101.2021.1953755"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34313533"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34313533"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Xu Yang, Haosheng Chen, Hong Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SNHG12 Promotes Osteoarthritis Progression Through Targeted Down-Regulation of miR-16-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Lab (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7754/Clin.Lab.2021.210402"}], "href": "https://doi.org/10.7754/Clin.Lab.2021.210402"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35023690"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35023690"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "Zhi-Ran Li, Qin Yang, Tao Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic Value of Long Noncoding RNA SNHG12 in Various Carcinomas: A Meta-Analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/8847401"}], "href": "https://doi.org/10.1155/2020/8847401"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33294456"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33294456"}]}, {"type": "r", "ref": 42, "children": [{"type": "t", "text": "Yusheng Huang, Lei Xia, Xiangwu Tan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular mechanism of lncRNA SNHG12 in immune escape of non-small cell lung cancer through the HuR/PD-L1/USP8 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol Lett (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s11658-022-00343-7"}], "href": "https://doi.org/10.1186/s11658-022-00343-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35658874"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35658874"}]}, {"type": "r", "ref": 43, "children": [{"type": "t", "text": "Bin Zhang, Yang He, Gui Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of stemness index-related long noncoding RNA SNHG12 in human bladder cancer based on WGCNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Probes (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mcp.2022.101867"}], "href": "https://doi.org/10.1016/j.mcp.2022.101867"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36183925"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36183925"}]}]}]}