{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have demonstrated that the long non‐coding RNA SNHG15 is frequently overexpressed in a wide variety of solid tumors—including breast, colon, non‐small cell lung, renal, gastric, colorectal, prostate, hepatocellular, ovarian, gallbladder cancers and others—and that its elevated levels are closely associated with advanced tumor node metastasis stage, invasion, chemoresistance and poor overall survival. In several reports, high SNHG15 expression in tumor tissues was correlated with enhanced proliferation and migration, promotion of epithelial–mesenchymal transition, and resistance to apoptosis, making it a promising prognostic biomarker and potential therapeutic target in oncology."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistically, SNHG15 exerts its oncogenic functions largely via post‐transcriptional regulation through acting as a competing endogenous RNA. It “sponges” diverse microRNAs—such as miR‐211‐3p in breast and lung cancers, miR‐338‐3p in colorectal and prostate cancers, miR‐153 in glioma endothelial cells, miR‐141‐3p in hepatocellular carcinoma, miR‐451 in gefitinib‐resistant lung adenocarcinoma, miR‐370‐3p in ovarian cancer, and miR‐335‐3p in myocardial ischemia/reperfusion injury—to modulate the expression or stability of key proteins including Slug, CDK14, FOS, RAB14, FKBP1A, VEGFA, and others. In doing so, SNHG15 not only fosters malignant cell proliferation, migration, invasion and epithelial–mesenchymal transition but also contributes to chemoresistance and altered metabolic pathways, further underscoring its significance as a regulator of tumor progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}, {"type": "fg_fs", "start_ref": "9", "end_ref": "12"}, {"type": "fg_f", "ref": "14"}, {"type": "fg_f", "ref": "24"}, {"type": "fg_f", "ref": "20"}, {"type": "fg_f", "ref": "26"}, {"type": "fg_f", "ref": "21"}, {"type": "fg_f", "ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in malignant tumors, SNHG15 has been implicated in non‐neoplastic conditions and as a circulating biomarker. In studies of pancreatic ductal adenocarcinoma and spinal tuberculosis, as well as in models of osteoarthritis and ischemia/reperfusion injury, alterations in SNHG15 expression modulated cellular apoptosis, extracellular matrix homeostasis, autophagy and inflammatory signaling. Moreover, serum exosomal SNHG15 levels have been evaluated for their diagnostic value, particularly in non‐small cell lung cancer, highlighting the broad potential clinical application of SNHG15 beyond oncogenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "27", "end_ref": "31"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Su-Xiu Chen, Jun-Feng Yin, Bao-Chai Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulated expression of long noncoding RNA SNHG15 promotes cell proliferation and invasion through regulates MMP2/MMP9 in patients with GC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-015-4404-0"}], "href": "https://doi.org/10.1007/s13277-015-4404-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26662309"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26662309"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yawen Ma, Yixue Xue, Xiaobai Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SNHG15 affects the growth of glioma microvascular endothelial cells by negatively regulating miR-153."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2017.5985"}], "href": "https://doi.org/10.3892/or.2017.5985"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29048682"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29048682"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Qingli Kong, Min Qiu "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA SNHG15 promotes human breast cancer proliferation, migration and invasion by sponging miR-211-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2017.12.013"}], "href": "https://doi.org/10.1016/j.bbrc.2017.12.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29217194"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29217194"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hao Jiang, Tingting Li, Yi Qu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA SNHG15 interacts with and stabilizes transcription factor Slug and promotes colon cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2018.03.038"}], "href": "https://doi.org/10.1016/j.canlet.2018.03.038"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29604394"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29604394"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Bing Jin, Hua Jin, Hai-Bo Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA SNHG15 promotes CDK14 expression via miR-486 to accelerate non-small cell lung cancer cells progression and metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.26543"}], "href": "https://doi.org/10.1002/jcp.26543"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29630731"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29630731"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yang Du, Chuize Kong, Yuyan Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of SNHG15 suppresses renal cell carcinoma proliferation and EMT by regulating the NF-κB signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2018.4395"}], "href": "https://doi.org/10.3892/ijo.2018.4395"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29750422"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29750422"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Y-Z Dong, X-M Meng, G-S Li "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA SNHG15 indicates poor prognosis of non-small cell lung cancer and promotes cell proliferation and invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201805_14963"}], "href": "https://doi.org/10.26355/eurrev_201805_14963"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29771418"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29771418"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Liang Huang, Hongcheng Lin, Liang Kang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aberrant expression of long noncoding RNA SNHG15 correlates with liver metastasis and poor survival in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.27456"}], "href": "https://doi.org/10.1002/jcp.27456"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30317592"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30317592"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "H-X Cui, M-Y Zhang, K Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SNHG15 promotes proliferation and migration of lung cancer via targeting microRNA-211-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201810_16152"}], "href": "https://doi.org/10.26355/eurrev_201810_16152"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30402848"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30402848"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "X-R Ma, Y-L Xu, J Qian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA SNHG15 accelerates the progression of non-small cell lung cancer by absorbing miR-211-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201902_17112"}], "href": "https://doi.org/10.26355/eurrev_201902_17112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30840276"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30840276"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Min Li, Zehua Bian, Guoying Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA-SNHG15 enhances cell proliferation in colorectal cancer by inhibiting miR-338-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.2105"}], "href": "https://doi.org/10.1002/cam4.2105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30945457"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30945457"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Yuelong Zhang, Dahong Zhang, Jia Lv, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SNHG15 acts as an oncogene in prostate cancer by regulating miR-338-3p/FKBP1A axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2019.04.033"}], "href": "https://doi.org/10.1016/j.gene.2019.04.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30981837"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30981837"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Morvarid Saeinasab, Ahmad Reza Bahrami, Jovanna González, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SNHG15 is a bifunctional MYC-regulated noncoding locus encoding a lncRNA that promotes cell proliferation, invasion and drug resistance in colorectal cancer by interacting with AIF."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-019-1169-0"}], "href": "https://doi.org/10.1186/s13046-019-1169-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31014355"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31014355"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Junfeng Ye, Ludong Tan, Yu Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SNHG15 promotes hepatocellular carcinoma progression by sponging miR-141-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.29283"}], "href": "https://doi.org/10.1002/jcb.29283"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31310393"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31310393"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jakub Hofman, Ales Sorf, Dimitrios Vagiannis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Brivanib Exhibits Potential for Pharmacokinetic Drug-Drug Interactions and the Modulation of Multidrug Resistance through the Inhibition of Human ABCG2 Drug Efflux Transporter and CYP450 Biotransformation Enzymes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pharm (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.molpharmaceut.9b00361"}], "href": "https://doi.org/10.1021/acs.molpharmaceut.9b00361"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31633365"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31633365"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Wei Dai, Jia-Liang Dai, Mao-Hua Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA-SNHG15 accelerates the development of hepatocellular carcinoma by targeting miR-490-3p/ histone deacetylase 2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Gastroenterol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3748/wjg.v25.i38.5789"}], "href": "https://doi.org/10.3748/wjg.v25.i38.5789"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31636472"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31636472"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "You Shuai, Zhonghua Ma, Jianwei Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SNHG15: A new budding star in human cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Prolif (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cpr.12716"}], "href": "https://doi.org/10.1111/cpr.12716"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31774607"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31774607"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "L-B Liu, Z-J Jiang, X-L Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Up-regulation of SNHG15 facilitates cell proliferation, migration, invasion and suppresses cell apoptosis in breast cancer by regulating miR-411-5p/VASP axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202002_20368"}], "href": "https://doi.org/10.26355/eurrev_202002_20368"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32141559"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32141559"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Zhiping Chen, Tianyu Zhong, Tao Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SNHG15 modulates gastric cancer tumorigenesis by impairing miR-506-5p expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20204177"}], "href": "https://doi.org/10.1042/BSR20204177"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33899079"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33899079"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Mingming Kang, Fangchao Ji, Xingyuan Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SNHG15 Promotes Oxidative Stress Damage to Regulate the Occurrence and Development of Cerebral Ischemia/Reperfusion Injury by Targeting the miR-141/SIRT1 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Healthc Eng (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/6577799"}], "href": "https://doi.org/10.1155/2021/6577799"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34868528"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34868528"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Min Li, Shengbai Sun, Zehua Bian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SNHG15 promotes chemoresistance and glycolysis in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2023.154480"}], "href": "https://doi.org/10.1016/j.prp.2023.154480"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37148838"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37148838"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "He Min, Linhua Yang, Xinsen Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SNHG15 promotes gallbladder cancer progression by enhancing the autophagy of tumor cell under nutrition stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2023.2278339"}], "href": "https://doi.org/10.1080/15384101.2023.2278339"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37937948"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37937948"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Mehdi Beyrami, Iraj Khodadadi, Heidar Tavilani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Uncovering the relationship between YAP/ WWTR1 (TAZ) genes expression and LncRNAs of SNHG15, HCP5 and LINC01433 in breast cancer tissues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2024.155286"}], "href": "https://doi.org/10.1016/j.prp.2024.155286"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38599044"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38599044"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Jiayuan Huang, Banzhou Pan, Guohao Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SNHG15 regulates EGFR-TKI acquired resistance in lung adenocarcinoma through sponging miR-451 to upregulate MDR-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-2683-x"}], "href": "https://doi.org/10.1038/s41419-020-2683-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32655137"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32655137"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Daniel Pensold, Julia Gehrmann, Georg Pitschelatow, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Expression of the Cancer-Associated lncRNA "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Snhg15"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Is Modulated by EphrinA5-Induced Signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms22031332"}], "href": "https://doi.org/10.3390/ijms22031332"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33572758"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33572758"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Haibo Du, Lianqin Ding, Tian Zeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SNHG15 Modulates Ischemia-Reperfusion Injury in Human AC16 Cardiomyocytes Depending on the Regulation of the miR-335-3p/TLR4/NF-κB Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Heart J (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1536/ihj.21-511"}], "href": "https://doi.org/10.1536/ihj.21-511"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35650158"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35650158"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "X-B Guo, H-S Yin, J-Y Wang "}, {"type": "b", "children": [{"type": "t", "text": "Evaluating the diagnostic and prognostic value of long non-coding RNA SNHG15 in pancreatic ductal adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201809_15917"}], "href": "https://doi.org/10.26355/eurrev_201809_15917"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30280769"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30280769"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Z-Z Liu, C-Y Zhang, L-L Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elevated expression of lncRNA SNHG15 in spinal tuberculosis: preliminary results."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201910_19303"}], "href": "https://doi.org/10.26355/eurrev_201910_19303"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31696491"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31696491"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Xing Zhang, Chao-Ran Huang, Sheng Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA SNHG15 is a competing endogenous RNA of miR-141-3p that prevents osteoarthritis progression by upregulating BCL2L13 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Immunopharmacol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.intimp.2020.106425"}], "href": "https://doi.org/10.1016/j.intimp.2020.106425"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32247266"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32247266"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Yunping Chen, Hongna Guo, Lang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Non-Coding RNA (lncRNA) Small Nucleolar RNA Host Gene 15 (SNHG15) Alleviates Osteoarthritis Progression by Regulation of Extracellular Matrix Homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/MSM.923868"}], "href": "https://doi.org/10.12659/MSM.923868"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32643707"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32643707"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Pengfei Han, Jia Zhao, Lun Gao "}, {"type": "b", "children": [{"type": "t", "text": "Increased serum exosomal long non-coding RNA SNHG15 expression predicts poor prognosis in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.23979"}], "href": "https://doi.org/10.1002/jcla.23979"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34551140"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34551140"}]}]}]}